• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Agnuside
    Information
    CAS No. 11027-63-7 Price $158 / 10mg
    Catalog No.CFN99203Purity>=98%
    Molecular Weight466.4 Type of CompoundIridoids
    FormulaC22H26O11Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $191.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Griffith University (Australia)
  • Seoul National University of Sc... (Korea)
  • Max Rubner-Institut (MRI) (Germany)
  • Fraunhofer-Institut für Moleku... (Germany)
  • MTT Agrifood Research Finland (Finland)
  • Universidade de Franca (Brazil)
  • Rio de Janeiro State University (Brazil)
  • Universit?t Basel (Switzerland)
  • Copenhagen University (Denmark)
  • University of Bordeaux (France)
  • Universidad Veracuzana (Mexico)
  • More...
  • Package
    Featured Products
    Alisol A 23-acetate

    Catalog No: CFN92544
    CAS No: 19865-75-9
    Price: $418/5mg
    Decursin

    Catalog No: CFN98509
    CAS No: 5928-25-6
    Price: $228/20mg
    20R-Ginsenoside Rg2

    Catalog No: CFN90412
    CAS No: 80952-72-3
    Price: $298/20mg
    Voacangine

    Catalog No: CFN92252
    CAS No: 510-22-5
    Price: $463/5mg
    3-Epioleanolic acid

    Catalog No: CFN92068
    CAS No: 25499-90-5
    Price: $388/10 mg
    Hesperetin

    Catalog No: CFN98842
    CAS No: 520-33-2
    Price: $40/20mg
    Quercetin-3-O-glucuronide

    Catalog No: CFN92172
    CAS No: 22688-79-5
    Price: $198/10mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
  • Cytotoxic Compound Library
  • Anti-arthritic Compound Library
  • Iridoids Compound Library
  • TNF-α Inhibitor Library
  • PGE Inhibitor Library
  • IL Receptor Inhibitor Library
  • IFN-γ Inhibitor Library
  • Biological Activity
    Description: Agnuside has anti-arthritic activity, it also shows inhibition of vascular permeability and leukocyte migration in vivo.It inhibited an array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-α, IFN-γ, IL-4, IL-10, IL-17).
    Targets: TNF-α | PGE | LTB | IL Receptor | IFN-γ
    In vivo:
    Inflamm Res. 2012 Apr;61(4):293-304.
    Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.[Pubmed: 22228102]
    The purpose of this study was to elucidate the probable mechanism for the anti-arthritic activity of Agnuside (AGN), a compound isolated from the leaf extract of Vitex negundo.
    METHODS AND RESULTS:
    The anti-inflammatory activity of AGN within a dose range of 1.56-12.50 mg/kg in normal and adrenalectomized rats was evaluated against different inflammagens. An array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-α, IFN-γ, IL-4, IL-10, IL-17) was assayed using flow cytometry, in arthritic paw tissue homogenate and splenocytes of treated animals. Significant anti-arthritic activity was observed in the polyarthritis test in rats and this was associated with significant suppression of inflammatory mediators and T-cell-mediated cytokines (Th1/Th2). The anti-inflammatory activity in adrenalectomized rats confirmed that the effect of AGN is not mediated by the pituitary-adrenal axis. AGN also showed inhibition of vascular permeability and leukocyte migration in vivo.
    CONCLUSIONS:
    The study suggests the possible development of AGN as a therapeutic agent in the treatment of arthritis by the modulation of the host immune response.
    Agnuside Description
    Source: The herbs of Vitex negundo L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    1,5-Dicaffeoylquinic acid

    Catalog No: CFN99123
    CAS No: 30964-13-7
    Price: $298/20mg
    Angelol A

    Catalog No: CFN90999
    CAS No: 19625-17-3
    Price: $198/10mg
    Batatasin III

    Catalog No: CFN92689
    CAS No: 56684-87-8
    Price: $368/5mg
    Acetylshikonin

    Catalog No: CFN90308
    CAS No: 54984-93-9
    Price: $418/20mg
    Epiaschantin

    Catalog No: CFN96901
    CAS No: 41689-50-3
    Price: $368/5mg
    Lonicerin

    Catalog No: CFN95055
    CAS No: 25694-72-8
    Price: $168/10mg
    (-)-Lyoniresinol 9'-O-glucoside

    Catalog No: CFN96732
    CAS No: 143236-02-6
    Price: $513/5mg
    (+)-Lyoniresinol 9'-O-glucoside

    Catalog No: CFN97964
    CAS No: 87585-32-8
    Price: $418/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1441 mL 10.7204 mL 21.4408 mL 42.8816 mL 53.6021 mL
    5 mM 0.4288 mL 2.1441 mL 4.2882 mL 8.5763 mL 10.7204 mL
    10 mM 0.2144 mL 1.072 mL 2.1441 mL 4.2882 mL 5.3602 mL
    50 mM 0.0429 mL 0.2144 mL 0.4288 mL 0.8576 mL 1.072 mL
    100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.4288 mL 0.536 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Inflamm Res. 2012 Apr;61(4):293-304.
    Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.[Pubmed: 22228102]
    Animal Models: Fourteen-week-old Wistar rats (150–180 g) and 12-weekold Swiss albino mice (24–30 g)
    Formulation: A suspension in gumacacia (1% w/v)
    Dosages: 1.56, 3.12, 6.25, 12.50 mg/kg
    Administration: p.o.