• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Gypenoside XLVI
    CAS No. 94705-70-1 Price $318 / 10mg
    Catalog No.CFN93372Purity>=98%
    Molecular Weight963.2Type of CompoundTriterpenoids
    FormulaC48H82O19Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $796.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Heinrich-Heine-University Düss... (Germany)
  • Auburn University (USA)
  • Universiti Sains Malaysia (Malaysia)
  • Chang Gung University (Taiwan)
  • University of Hull (United Kingdom)
  • University of Perugia (Italy)
  • University of Illinois at Chicago (USA)
  • University of British Columbia (Canada)
  • Nicolaus Copernicus Uniwersity (Poland)
  • MTT Agrifood Research Finland (Finland)
  • University of Helsinki (Finland)
  • More...
  • Package
    Featured Products
    Cimicidanol 3-O-alpha-L-arabinoside

    Catalog No: CFN90863
    CAS No: 161207-05-2
    Price: $268/20mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $510/5mg
    Ganoderic acid DM

    Catalog No: CFN99815
    CAS No: 173075-45-1
    Price: $592/5mg

    Catalog No: CFN98842
    CAS No: 520-33-2
    Price: $40/20mg

    Catalog No: CFN97160
    CAS No: 6807-83-6
    Price: $128/20mg
    Picroside III

    Catalog No: CFN99567
    CAS No: 64461-95-6
    Price: $228/20mg

    Catalog No: CFN99883
    CAS No: 19103-54-9
    Price: $338/10mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
  • Triterpenoids Compound Library
  • Biological Activity
    Description: Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml.
    In vitro:
    Faseb J., 2014, 28(1).
    Cytotoxic activity of gypenosides and gynogenin from Gynostemma pentaphyllum against A549 cells [Reference: WebLink]
    Gynostemma pentaphyllum (Thunb.) Makino is one of the well-known traditional Chinese herbal medicines, which has been demonstrated to be effective against chronic diseases, such as lung cancer. In the present study, seven dammarane-type compounds were isolated from the raw, heat processed and alkaline hydrolyzed G. Pentaphyllum and compared for their cytotoxic activities against non-small cell lung carcinoma A549 cells using MTT cytotoxicity assay.
    By means of chemical and spectroscopic methods, their structures were established as gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α, 3β, 12β, 20-tetrol. Gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α,3β,12β,20-tetrol all showed strong cytotoxic activity against A549 cells, with the IC50 values of 105.89±2.48, 52.63±8.31, 34.94±4.23, 50.96±9.55, 26.98±0.51, 4.56±0.58, 12.54±0.53 μg/ml respectively, whereas the IC50 value of 20S-Rg3 (positive control) was 55.36±3.20 μg/ml. Comparing their structures with cytotoxic activity, these compounds might possess some kind of structure-activity relationship.
    Based on the structure and cytotoxic activity relationships of these seven constituents, the OH group in C-2, the double bond in C20(21) and C20(22) positions, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells.
    Gypenoside XLVI Description
    Source: The roots of Panax notoginseng (Burk.) F.H.Chen
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Bryonamide B

    Catalog No: CFN91057
    CAS No: 5942-25-6
    Price: $218/5mg

    Catalog No: CFN95052
    CAS No: 58274-56-9
    Price: $260/10mg

    Catalog No: CFN99137
    CAS No: 3371-27-5
    Price: $178/20mg

    Catalog No: CFN98775
    CAS No: 487-36-5
    Price: $268/20mg
    Magnoloside A

    Catalog No: CFN99232
    CAS No: 113557-95-2
    Price: $318/5mg

    Catalog No: CFN91058
    CAS No: 484-14-0
    Price: $298/10mg

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    20-O-Glucoginsenoside Rf

    Catalog No: CFN95036
    CAS No: 68406-27-9
    Price: $368/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0382 mL 5.191 mL 10.3821 mL 20.7641 mL 25.9551 mL
    5 mM 0.2076 mL 1.0382 mL 2.0764 mL 4.1528 mL 5.191 mL
    10 mM 0.1038 mL 0.5191 mL 1.0382 mL 2.0764 mL 2.5955 mL
    50 mM 0.0208 mL 0.1038 mL 0.2076 mL 0.4153 mL 0.5191 mL
    100 mM 0.0104 mL 0.0519 mL 0.1038 mL 0.2076 mL 0.2596 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.