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    Hispidulin 7-O-neohesperidoside
    Information
    CAS No. 156186-00-4 Price
    Catalog No.CFN90892Purity>=98%
    Molecular Weight608.6Type of CompoundFlavonoids
    FormulaC28H32O15Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Hispidulin 7-O-neohesperidoside is one of the active substances responsible for the protective effects of this plant.
    In vivo:
    Phytother Res. 2004 Jan;18(1):19-24.
    Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats.[Pubmed: 14750195]
    Effects of the methanol extract of Cirsium japonicum var. ussuriense and Hispidulin 7-O-neohesperidoside isolated from the plant on hepatic alcohol-metabolizing enzymes and lipid peroxidation were studied in rats treated with ethanol.
    METHODS AND RESULTS:
    Rats treated with 10% alcohol solution for 6 weeks were orally administered with 250 or 500 mg of methanol extract or 10 or 20 mg of Hispidulin 7-O-neohesperidoside per kg body weight daily during the last week of ethanol treatment. The administration of the methanol extract of herbal plant and Hispidulin 7-O-neohesperidoside in ethanol-treated rats significantly enhanced the activities of hepatic alcohol dehydrogenase, microsomal ethanol-oxidizing system and aldehyde dehydrogenase in a dose-dependent manner. The extract and the compound decreased hepatic lipid peroxidation along with an increase in hepatic content of reduced glutathione. The methanol extract and Hispidulin 7-O-neohesperidoside of C. japonicum var. ussuriense also increased the activity of glutathione reductase, but had no effect on gamma-glutamylcysteine synthase.
    CONCLUSIONS:
    The results suggest that C. japonicum var. ussuriense may alleviate alcoholic toxicity by enhancing ethanol oxidation as well as inhibiting lipid peroxidation, and Hispidulin 7-O-neohesperidoside is one of the active substances responsible for the protective effects of this plant.
    Hispidulin 7-O-neohesperidoside Description
    Source: The herbs of Plantago asiatica L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6431 mL 8.2156 mL 16.4312 mL 32.8623 mL 41.0779 mL
    5 mM 0.3286 mL 1.6431 mL 3.2862 mL 6.5725 mL 8.2156 mL
    10 mM 0.1643 mL 0.8216 mL 1.6431 mL 3.2862 mL 4.1078 mL
    50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6572 mL 0.8216 mL
    100 mM 0.0164 mL 0.0822 mL 0.1643 mL 0.3286 mL 0.4108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.