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    Natural Products
    Humantenine
    Humantenine
    Information
    CAS No. 82375-29-9 Price
    Catalog No.CFN97305Purity>=98%
    Molecular Weight354.5 Type of CompoundAlkaloids
    FormulaC21H26N2O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Alkaloids Compound Library
  • Biological Activity
    Description: Standard reference
    In vitro:
    J Nat Prod. 2015 Jul 24;78(7):1511-7.
    Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans.[Pubmed: 26103517]

    METHODS AND RESULTS:
    Nine new alkaloids of the koumine (1-4), Humantenine (5-7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-Humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring alkaloids, respectively, of the yohimbane type.
    CONCLUSIONS:
    Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6-9.3 μM.
    Humantenine Description
    Source: The roots of Gelsemium elegans
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Nature Plants. 2016 Dec 22;3: 16206.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8209 mL 14.1044 mL 28.2087 mL 56.4175 mL 70.5219 mL
    5 mM 0.5642 mL 2.8209 mL 5.6417 mL 11.2835 mL 14.1044 mL
    10 mM 0.2821 mL 1.4104 mL 2.8209 mL 5.6417 mL 7.0522 mL
    50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.1283 mL 1.4104 mL
    100 mM 0.0282 mL 0.141 mL 0.2821 mL 0.5642 mL 0.7052 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 2011 May;36(10):1305-10.
    Chemical constituents of aerial parts of Gelsemium elegans.[Pubmed: 21837971]
    To study the chemical constituents from the aerial parts of Gelsemium elegans.
    METHODS AND RESULTS:
    Compounds were isolated and purified by repeated column chromatography, as well as semiprep arative HPLC, and their structures were identified by physicochemical properties and spectroscopic methods, such as NMR and MS. Sixteen compounds were obtained and identified from G. elegans, including nine alkaloids: koumine (1), gelsenicine (2), 19-(Z)-akuammidine (3), gelsemoxonine(4), gelsemin (5), gelsevirine (6), Humantenine (7), 11-methoxygelsemamide (8) and gelegamine D (9). Three megastigmane glycosides: (3R, 5S, 6S, 7E, 9R)-megastigman-7-ene-3, 5, 6, 9-tetrol-9-O-beta-D-glucopyranoside (10), (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranoside] (11) and (6S, 7E, 9R) -6, 9-dihydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 --> 6) -beta-D-glucopyranoside] (12). Two flavone C-glycosides: orientin (13) and isorientin (14); one iridoid glycoside, sweroside (15) and one fructoside, n-butyl-alpha-D-fructofuranoside (16).
    CONCLUSIONS:
    Compounds 10-16 were isolated from the genus Gelsemium for the first time.