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    Chebulagic acid
    CAS No. 23094-71-5 Price
    Catalog No.CFN92295Purity>=98%
    Molecular Weight954.7Type of CompoundPhenols
    FormulaC41H30O27Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Chebulagic acid shows anti-HIV activity.
    2. Chebulagic acid is a potent DNA topoisomerase inhibitor.
    3. Chebulagic acid can be used to control blood glucose and manage type 2 diabetes, although clinical trials are needed.
    4. Chebulagic acid, a COX-2 and 5-LOX dual inhibitor isolated from the fruits of Terminalia chebula, induces apoptosis in COLO-205 cells.
    5. Chebulagic acid may be of value as broad-spectrum antivirals for limiting emerging/ recurring viruses known to engage host cell glycosaminoglycans for entry.
    Targets: COX | LOX | Topoisomerase | HIV | AMPK | Autophagy | mTOR | ATPase | PPAR | GLUT | Bcl-2/Bax | Caspase | P450 (e.g. CYP17) | CDK | NF-kB | MMP(e.g.TIMP) | VEGFR | IkB | IKK
    Chebulagic acid Description
    Source: The fruits of Terminalia chebula
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
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    J Cell Biochem. 2018 Feb;119(2):2231-2239.
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    Phytomedicine. 2018 Feb 1;40:37-47.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0474 mL 5.2372 mL 10.4745 mL 20.949 mL 26.1862 mL
    5 mM 0.2095 mL 1.0474 mL 2.0949 mL 4.1898 mL 5.2372 mL
    10 mM 0.1047 mL 0.5237 mL 1.0474 mL 2.0949 mL 2.6186 mL
    50 mM 0.0209 mL 0.1047 mL 0.2095 mL 0.419 mL 0.5237 mL
    100 mM 0.0105 mL 0.0524 mL 0.1047 mL 0.2095 mL 0.2619 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Chebulagic acid References Information
    Citation [1]

    Biomol Ther (Seoul). 2014 Jul;22(4):275-81.

    Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells.[Pubmed: 25143804]
    Chebulagic acid, the major constituent of Terminalia chebula and Phyllanthus emblica, is a benzopyran tannin compound with various kinds of beneficial effects. This study was performed to investigate the autophagy enhancing effect of Chebulagic acid on human neuroblastoma SH-SY5Y cell lines. We determined the effect of Chebulagic acid on expression levels of autophago-some marker proteins such as, DOR/TP53INP2, Golgi-associated ATPase Enhancer of 16 kDa (GATE 16) and Light chain 3 II (LC3 II), as well as those of its upstream pathway proteins, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Beclin-1. All of those proteins were modulated by Chebulagic acid treatment in a way of enhancing the autophagy. Additionally in our study, Chebulagic acid also showed a protective effect against 1-methyl-4-phenylpyridinium (MPP(+)) - induced cytotoxicity which mimics the pathological symptom of Parkinson's disease. This effect seems partially mediated by enhanced autophagy which increased the degradation of aggregated or misfolded proteins from cells. This study suggests that Chebulagic acid is an attractive candidate as an autophagy-enhancing agent and therefore, it may provide a promising strategy to prevent or cure the diseases caused by accumulation of abnormal proteins including Parkinson's disease.
    Citation [2]

    Biofactors. 2014 Nov-Dec;40(6):646-57.

    Chebulagic acid from Terminalia chebula enhances insulin mediated glucose uptake in 3T3-L1 adipocytes via PPARγ signaling pathway.[Pubmed: 25529897]
    We studied Chebulagic acid (CHA) isolated from fruits of Terminalia chebula with respect to its effect on adipogenesis, glucose transport, and endocrine function of adipocyte. The mRNA expression profile of PPARγ target gene CCAAT/enhancer-binding protein alpha (C/EBP-α) was analyzed by qRT-PCR. The putative binding mode and the potential ligand-target interactions of Chebulagic acid, with PPARγ was analyzed using docking software (Autodock and iGEMDOCKv2). The results showed that Chebulagic acid enhances PPARγ signaling and adipogenesis dose dependently but in a moderate way, less than rosiglitazone. GLUT4 expression and adiponectin secretion was increased by Chebulagic acid treatment. The mRNA expression of PPARγ target gene C/EBP-α was increased in Chebulagic acid -treated adipocytes. The comparison of results of various parameters of adipogenesis, insulin sensitivity, endocrine function and molecular docking experiments of roziglitazone and Chebulagic acid indicate that the latter behaves like partial PPARγ agonist which could be exploited for phytoceutical development against T2DM.
    Citation [3]

    BMC Complement Altern Med. 2014 Aug 29;14:319.

    Chebulagic acid from Terminalia chebula causes G1 arrest, inhibits NFκB and induces apoptosis in retinoblastoma cells.[Pubmed: 25169718]
    Chebulagic acid (CA) from Terminalia chebula was shown to have anti-proliferative properties in the studies on cancerous cell lines. Due to anti cancer properties of Chebulagic acid and due to limitation in treatment options for retinoblastoma, the present study is undertaken to understand the role of Chebulagic acid on the proliferation of retinoblastoma cells. METHODS: Anti proliferative potential of Chebulagic acid was determined by MTT assay. The expression levels of various cell death mediators in retinoblastoma cells with Chebulagic acid treatment were assessed by Western blotting. Flowcytometer analysis was used to estimate the mitochondrial membrane potential (MMP) and to determine the percentage of cells undergoing apoptosis. RESULTS: The present study showed Chebulagic acid inhibited the proliferation of retinoblastoma cells in a dose dependent manner. Chebulagic acid modulated MMP, induced release of Cytochrome c, activated caspase 3 and shifted the ratio of BAX and Bcl2 towards cell death. G1 arrest, noticed in Chebulagic acid treated cells, is mediated by the increase in the expression of CDK inhibitor p27. Chebulagic acid treatment also decreased the levels of NFκB in the nucleus. This decrease is mediated by suppression in degradation of IκBα. CONCLUSION: Chebulagic acid has shown significant anti proliferative potential on retinoblastoma cells. Our findings clearly demonstrate that Chebulagic acid induces G1 arrest, inhibits NFκB and induces apoptosis of retinoblastoma cells.
    Citation [4]

    Int J Mol Sci. 2012;13(5):6320-33.

    Anti-hyperglycemic effect of chebulagic acid from the fruits of Terminalia chebula Retz.[Pubmed: 22754367]
    By HPLC analysis, it was determined that the 80% ethanol extract had a higher content of Chebulagic acid than each of 50% or 100% ethanol extract. Next, we investigated how efficiently Chebulagic acid could inhibit sugar digestion by determining the glucose level on the apical side of the Caco-2 cell monolayer. The result showed that the maltose-hydrolysis activity was down-regulated by Chebulagic acid, which proved to be a reversible inhibitor of maltase in Caco-2 cells. On the other hand, Chebulagic acid showed a weak inhibition of sucrose-hydrolysis activity. Meanwhile, Chebulagic acid did not have an obvious influence on intestinal glucose uptake and was not effective on glucose transporters. Further animal studies revealed that the oral administration of Chebulagic acid (100 mg/kg body weight) significantly reduced postprandial blood glucose levels by 11.1% in maltose-loaded Sprague-Dawley (SD) rats compared with the control group, whereas the oral administration of Chebulagic acid did not show a suppressive effect on postprandial hyperglycemia in sucrose- or glucose-loaded SD-rats. The results presented here suggest that Chebulagic acid from T. chebula can be used to control blood glucose and manage type 2 diabetes, although clinical trials are needed.
    Citation [5]

    Sci Rep. 2015 Apr 10;5:9642.

    The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions.[Pubmed: 25859636]
    We here in report that low dose of Chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. Chebulagic acid may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.