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    Isodemethylwedelolacton
    Information
    CAS No. 350681-33-3 Price $418 / 20mg
    Catalog No.CFN90625Purity>=98%
    Molecular Weight300.22Type of CompoundCoumarins
    FormulaC15H8O7Physical DescriptionYellow powder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Isodemethylwedelolacton Description
    Source: The herbs of Eclipta prostrata
    Biological Activity or Inhibitors:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3309 mL 16.6545 mL 33.3089 mL 66.6178 mL 83.2723 mL
    5 mM 0.6662 mL 3.3309 mL 6.6618 mL 13.3236 mL 16.6545 mL
    10 mM 0.3331 mL 1.6654 mL 3.3309 mL 6.6618 mL 8.3272 mL
    50 mM 0.0666 mL 0.3331 mL 0.6662 mL 1.3324 mL 1.6654 mL
    100 mM 0.0333 mL 0.1665 mL 0.3331 mL 0.6662 mL 0.8327 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isodemethylwedelolacton References Information
    Citation [1]

    Yao Xue Xue Bao. 2001 Jan;36(1):34-7.

    Studies on the chemical constituents of Eclipta prostrata (L).[Pubmed: 12579857]
    To study the chemical constituents of Eclipta prostrata (L). METHODS: The constituents of E. prostrata were systematically separated with the Bohlmann method and percolation and hot extraction methods, and various chromatographies. The structures were elucidated by chemical and spectroscopic means. RESULTS: Ten compounds were isolated from the Eclipta prostrata. Their structures were determined as wedelolactone (1), demethylwedelolactone (2), Isodemethylwedelolactone (3), alpha-formylterthienyl (4), strychnolactone (5), beta-sitosterol (6), nonacosanol (7), stearic acid (8), lacceroic acid (9), 3,4-dihydoxy benzoic acid (10). Fourteen ocmpounds, including hydrocarbons and its esters were identified by GC-MS from the least polar fractions. CONCLUSION: Compound 3 is a new coumestan named Isodemethylwedelolactone. Compounds 2-10 and compounds characterized by GC-MS analysis were obtained for the first time from Eclipta prostrata.
    Citation [2]

    Se Pu. 2007 May;25(3):371-3.

    Simultaneous determination of wedelolactone and isodemethylwedelolactone in Herba ecliptae by reversed-phase high performance liquid chromatography.[Pubmed: 17679432]
    A reversed-phase high performance liquid chromatographic method (RP-HPLC) was developed for the simultaneous determination of wedelolactone and Isodemethylwedelolactone in Herba Ecliptae from different sources. The separation was performed on a Kromasil C18 column (250 mm x 4.6 mm, 5 microm), with methanol-0.5% acetic acid (55 45, v/v) as mobile phase at a flow rate of 1.0 mL/min. The detection wavelength was set at 351 nm and the volume of injection was 20 microL. There were good linear relationships between the mass concentrations and the peak areas of Isodemethylwedelolactone and wedelolactone in the ranges of 1.6 - 32.0 mg/L (r = 0.999 5) and 5.6 - 112.0 mg/L (r = 0.999 8), respectively. The recoveries were found to be in the range of 97.5% - 98.2% and 99.0% - 100.2%, respectively. The results of the experiments have demonstrated that the established method is rapid and simple with good accuracy and reproducibility for the simultaneous determination of wedelolactone and Isodemethylwedelolactone. The method is suitable for the quality control of Herba Ecliptae from different sources.