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    CAS No. 139726-30-0 Price
    Catalog No.CFN99449Purity>=98%
    Molecular Weight398.5 Type of CompoundLignans
    FormulaC27H26O3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Isodunnianol, dunnianol, and Macranthol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5 -3.0 fold and decrease cellular oxidative stress by 40-65%, they show substantial activity against iNOS.
    2. Isodunnianol exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons.
    3. Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM.
    Targets: NF-kB | NOS | ROS
    Isodunnianol Description
    Source: The fruits of Illicium fargesii
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5094 mL 12.5471 mL 25.0941 mL 50.1882 mL 62.7353 mL
    5 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
    10 mM 0.2509 mL 1.2547 mL 2.5094 mL 5.0188 mL 6.2735 mL
    50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
    100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isodunnianol References Information
    Citation [1]

    Natural Products and Bioprospecting June 2012, Volume 2, Issue 3, pp 133-137.

    Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity[Reference: WebLink]
    A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4). As a result, Isodunnianol (7) exhibited anti-AChE activity with an IC50 value of 13.0 µM.
    Citation [2]

    Tetrahedron Volume 63, Issue 20, 14 May 2007, Pages 4243–4249

    Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii[Reference: WebLink]
    The structures of three new sesqui-neolignans, fargenin (1) and fargenones A and B (2 and 3), together with two previously known sesqui-neolignans, macranthol (4) and Isodunnianol (5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data.
    Citation [3]

    Planta Med.,2014, 80(10):807-807.

    Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference: WebLink]
    Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis. Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii. Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which dunnianol, macranthol and Isodunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%. These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity.
    Citation [4]

    Tetrahedron, 2007, 63(20):4243-9.

    Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii[Reference: WebLink]
    The structures of three new sesqui-neolignans, fargenin ( 1 ) and fargenones A and B ( 2 and 3 ), together with two previously known sesqui-neolignans, macranthol ( 4 ) and Isodunnianol ( 5 ), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1 – 3 are the second three examples of the sesqui-neolignans that contain a variety of non-aromatic rings, and their plausible biosynthetic routes from chavicol are proposed. Among the isolated sesqui-neolignans, Isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 1002μM in the primary cultured rat cortical neurons.