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    Jionoside B1
    CAS No. 120406-37-3 Price $448 / 10mg
    Catalog No.CFN90729Purity>=98%
    Molecular Weight814.78Type of CompoundPolyphenols
    FormulaC37H50O20Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Jionoside B1 has immunosuppressive activity, it shows the hepato-protective activity in the H2O2 induced liver injury experiments.Jionoside B1 exhibits the obvious inhibition against aldose reductase.
    In vitro:
    Chinese Traditional & Herbal Drugs, 2016, 47(11): 1830-3.
    Chemical constituents from whole plants of oehmannia chingii[Reference: WebLink]
    To investigate the chemical constituents of Rehmannia chingii.
    The compounds were isolated from an aqueous extract from the whole plants of R.chingii by a combination of various chromatographic techniques including column chromatography over silica gel and Sephadex LH-20 and reversed-phase HPLC.Their structures were identified by spectroscopic analysis including MS and NMR data. Seventeen compounds were isolated and identified as 8-methyloctahydrocyclopenta [c] pyran-1,3,6,8-tetraol(1),3,4-dihydroxy-phenethyl alcohol(2),3-methoxyl-4-hydroxyphenyl alcohol(3),phenylethyl-8-O-β-D-glucopyranoside(4),3,4-dihydroxy-β-phenethyl-O-α-L-rhamnopyranosyl-(1→3)-O-β-D-glucopyranoside(5),2-phenylethylO-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside(6),deacyl-martynoside(7),acteoside(8),isoacteoside(9),martynoside(10),isomartynoside(11),jionoside C(12),jionoside A1(13),Jionoside B1(14),3,4-dihydroxy-β-phenethyl-O-α-L-rhamnopyranosyl-(1→3)-O-β-D-galacopyranosyl-(1→6)-4-O-caffeoyl-β-D-glucopyranoside(15),cistanoside F(16),and isocistanoside F(17).
    Among the isolated seventeen compounds,compound 1 is a new compound named rehmachinin,and compounds 16-17 are isolated from the plants of Rehmannia Libosch.ex Fisch.et Mey.for the first time. In the preliminary assays,compounds 9,12,and 14-16 exhibit the obvious inhibition against aldose reductase.
    Jionoside B1 Description
    Source: The roots of Rehmannia glutinosa
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2273 mL 6.1366 mL 12.2733 mL 24.5465 mL 30.6831 mL
    5 mM 0.2455 mL 1.2273 mL 2.4547 mL 4.9093 mL 6.1366 mL
    10 mM 0.1227 mL 0.6137 mL 1.2273 mL 2.4547 mL 3.0683 mL
    50 mM 0.0245 mL 0.1227 mL 0.2455 mL 0.4909 mL 0.6137 mL
    100 mM 0.0123 mL 0.0614 mL 0.1227 mL 0.2455 mL 0.3068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(22):3125-9.
    Chemical constituents from Rehmannia glutinosa.[Pubmed: 22375391]
    To study the chemical constituents from the roots of Rehmannia glutinosa.
    The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Twelve compounds were isolated and their structures were identified as 5-hydroxymethyl-pyrrole-2-carbaldehyde (1), 5-hydroxymethyl furfural (2), tyrosol (3), 5,6-dihydroxy-beta-ionone (4), 6-O-E-feruloyl ajugol (5), acteoside (6), leucosceptoside A (7), martynoside (8), isomartynoside (9), purpureaside C (10), jionoside A1 (11), and Jionoside B1 (12).
    Compounds 1, 3 and 9 were isolated from the genus Rehmannia for the first time.