|Source:||The herbs of Phymatopteris hastate|
|Biological Activity or Inhibitors:||1. Juglanin shows protective effects on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats.
2. Juglanin can lead to G2/M phase arrest, induce apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells, it may be a promising candidate for development of anti-tumor drugs targeting breast cancer.
3. Juglanin shows antioxidant activities.
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.3901 mL||11.9503 mL||23.9006 mL||47.8011 mL||59.7514 mL|
|5 mM||0.478 mL||2.3901 mL||4.7801 mL||9.5602 mL||11.9503 mL|
|10 mM||0.239 mL||1.195 mL||2.3901 mL||4.7801 mL||5.9751 mL|
|50 mM||0.0478 mL||0.239 mL||0.478 mL||0.956 mL||1.195 mL|
|100 mM||0.0239 mL||0.1195 mL||0.239 mL||0.478 mL||0.5975 mL|
Biomedicine & Pharmacotherapy, 2016 ,81 :318-28.
|The protective effect of juglanin on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats.[Pubmed: 27261609]|
|Meanwhile, toll-like receptor 4 (TLR4)-modulated mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-κB) and apoptosis-related Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway are involved in the progression of hepatic injury and inflammation. And Juglanin was found to suppress fructose-feeding-induced activation of these signaling pathways compared with the model group administrated only with fructose. These results indicate that Juglanin represses inflammatory response and apoptosis via TLR4-regulated MAPK/NF-κB and JAK2/STAT3 signaling pathway respectively in rats with hepatitis induced by LPS for fructose-feeding. Treatment of Juglanin might be an effective therapeutic strategy for preventing hepatitis.|
Biomed Pharmacother. 2017 Jan;85:303-312.
|Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion.[Pubmed: 27899257 ]|
|Further, Juglanin also induced JNK activation and ROS production. The JNK inhibitor attenuated Juglanin-caused apoptosis and autophagy significantly while ROS scavenger could reverse them. In addition, the ROS scavenger also inhibited G2/M phase arrest and phosphorylated JNK. Of note, we found that Juglanin had the similar effects on breast cancer cells. Finally, Juglanin inhibited tumor growth in the mouse xenograft model in vivo. Together, our results suggested that Juglanin led to G2/M phase arrest, induced apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells. Hence, Juglanin might be a promising candidate for development of anti-tumor drugs targeting breast cancer.|
Arch Pharm Res. 2010 Feb;33(2):203-8.
|Two new C-glucosyl benzoic acids and flavonoids from Mallotus nanus and their antioxidant activity.[Pubmed: 20195819 ]|
|Two new 2-C-beta-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), Juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety.|