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    Khasianine
    Information
    CAS No. 32449-98-2 Price $208 / 20mg
    Catalog No.CFN90387Purity>=98%
    Molecular Weight721.93Type of CompoundAlkaloids
    FormulaC39H63NO11Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade de Franca (Brazil)
  • National Research Council of Can... (Canada)
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  • Kazusa DNA Research Institute (Japan)
  • Nicolaus Copernicus Uniwersity (Poland)
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    Biological Activity
    Description: Khasianine exhibits strong activity against liver damage induced by CCl4.
    In vitro:
    Biochem Biophys Res Commun. 1998 Jan 6;242(1):21-5.
    The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis.[Pubmed: 9439603]
    Solamargine, solasodine and Khasianine steroidal alkaloids are utilized to determine the role of carbohydrate moiety in the mechanism of apoptosis.
    METHODS AND RESULTS:
    The C3 side chain of solamargine, Khasianine and solasodine contains 4'Rha-Glc-Rha2', 4'Rha-Glc and H, respectively. Solamargine possessed potent cytotoxicity to human hepatoma cells, while the cytotoxicity of Khasianine was greatly diminished. Nevertheless, only solamargine could induced "sub-G1" of apoptotic feature in flowcytometry. Thus, the 2'Rha moiety of solamargine may play a crucial role in triggering cell death by apoptosis. In addition, the molecular modeling of solamargine indicated that the 2'Rha moiety was adjacent to the rigid steroid structure, and drastically changed the dihedral angle of the glycosidic bond.
    CONCLUSIONS:
    The regulations of TNFR I and II expression by different carbohydrate moieties were also distinct. It implied that the carbohydrate moieties of steroidal alkaloids might alter the binding specificity to steroid receptors and consequently regulate the gene expression in different manners.
    J Nat Prod. 1993 Jan;56(1):15-21.
    Cytotoxic principles and their derivatives of Formosan Solanum plants.[Pubmed: 8450317]

    METHODS AND RESULTS:
    The new steroidal alkaloid capsimine-3-O-beta-D-glucoside [1] was isolated from the root bark of Solanum capsicastrum, and carpesterol [2], 3 beta-(p-hydroxy)-benzoyloxy-22 alpha-hydroxy-4 alpha-methyl-5 alpha-stigmast-7-en-6-one [3], and a new steroidal glycoside named indioside A [4] were isolated from the fruit of Solanum indicum. Indioside A was characterized as 3 beta-O-[alpha-L-rhamnopyranosyl-(1-->2), beta-D-glucopyranosyl-(1-->4), beta-D-glucopyranosyl-(1-->3)-]alpha-L-rhamnopyranosyl-(-->2)]-beta-D- glucopyranosyl]-diosgenin. Khasianine, dihydrosolasodine, capsimine, and capsimine-3-O-beta-D-glucoside exhibited strong activity against liver damage induced by CCl4.
    CONCLUSIONS:
    Capsimine and narigenin exhibited significant cytotoxic effect against human PLC/PRF/5 and KB cells in vitro, and capsicastrine and etioline exhibited significant cytotoxicity against human PLC/PRF/5 cells in vitro.
    Khasianine Description
    Source: The herbs of Solanum nigrum L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3852 mL 6.9259 mL 13.8518 mL 27.7035 mL 34.6294 mL
    5 mM 0.277 mL 1.3852 mL 2.7704 mL 5.5407 mL 6.9259 mL
    10 mM 0.1385 mL 0.6926 mL 1.3852 mL 2.7704 mL 3.4629 mL
    50 mM 0.0277 mL 0.1385 mL 0.277 mL 0.5541 mL 0.6926 mL
    100 mM 0.0139 mL 0.0693 mL 0.1385 mL 0.277 mL 0.3463 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.