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    Lauterine
    Lauterine
    Information
    CAS No. 28200-65-9 Price
    Catalog No.CFN96757Purity>=98%
    Molecular Weight305.28Type of CompoundAlkaloids
    FormulaC18H11NO4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Lauterine is a DNA topoisomerase inhibitor.
    Targets: Topoisomerase
    Lauterine Description
    Source: The plants of Guatteria elata R. E. Fries.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2757 mL 16.3784 mL 32.7568 mL 65.5136 mL 81.892 mL
    5 mM 0.6551 mL 3.2757 mL 6.5514 mL 13.1027 mL 16.3784 mL
    10 mM 0.3276 mL 1.6378 mL 3.2757 mL 6.5514 mL 8.1892 mL
    50 mM 0.0655 mL 0.3276 mL 0.6551 mL 1.3103 mL 1.6378 mL
    100 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.6551 mL 0.8189 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Lauterine References Information
    Citation [1]

    J Nat Prod. 1994 Jan;57(1):68-73.

    Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.[Pubmed: 8158166]
    The oxoaporphine alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae). Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3], O-methylmoschatoline [4], and lysicamine [5], were also isolated from this plant. Selective toxicity was also observed for 10-methoxyliriodenine (Lauterine) [6] and 10-hydroxyliriodenine [7], two oxoaporphine alkaloids isolated from Miliusa cf. banacea (Annonaceae). The structure of 10-hydroxyliriodenine [7], a novel oxoaporphine, was determined by spectroscopic methods and chemical conversion to compound 6. The role of the bioactive oxoaporphine alkaloids as DNA topoisomerase inhibitors is discussed.
    Citation [2]

    Lloydia, 1977, 40(2):152-156.

    Isolation of lauterine and oxoputerine, two new oxoaporphine alkaloids from Guatteria elata[Reference: WebLink]
    Two new oxoaporphine alkaloids, Lauterine (1) and oxoputerine (4), were isolated from Guatteria elata R. E. Fries (Annonaceae). The structures of these alkaloids were established by interpretation of their uv, ir, pmr, and mass spectra, and by their transformation to laureline and pukateine methyl ether respectively. Oxoxylopine and lanuginosine were shown to be identical and therefore have the structure 2.