• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Leachianone A
    Information
    CAS No. 97938-31-3 Price $418 / 10mg
    Catalog No.CFN97560Purity>=98%
    Molecular Weight438.5 Type of CompoundFlavonoids
    FormulaC26H30O6Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Maryland School of... (USA)
  • Johannes Gutenberg University Ma... (Germany)
  • Lodz University of Technology (Poland)
  • Shanghai Institute of Biochemist... (China)
  • University of Padjajaran (Indonesia)
  • S.N.D.T. Women's University (India)
  • Institute of Tropical Disease Un... (Indonesia)
  • Florida A&M University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • CSIRO - Agriculture Flagship (Australia)
  • University of Vigo (Spain)
  • More...
  • Package
    Featured Products
    Terrestrosin D

    Catalog No: CFN90821
    CAS No: 179464-23-4
    Price: $268/10mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $510/5mg
    Tenuifolin

    Catalog No: CFN98157
    CAS No: 20183-47-5
    Price: $118/20mg
    Isochlorogenic acid C

    Catalog No: CFN99120
    CAS No: 32451-88-0
    Price: $138/20mg
    Przewalskin

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Biological Activity
    Description: 1. Leachianone A possesses a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment, its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways.
    2. Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity, furthermore, leachianone A shows dose-dependency in detoxication.
    3. Leachianone A exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
    Targets: SGLT
    Leachianone A Description
    Source: The roots of Sophora flavescens.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Epimagnolin A

    Catalog No: CFN90949
    CAS No: 41689-51-4
    Price: $268/10mg
    Oroxylin A

    Catalog No: CFN98540
    CAS No: 480-11-5
    Price: $138/20mg
    3,3',4',5,6,7,8-heptamethoxyflavon...

    Catalog No: CFN95021
    CAS No: 1178-24-1
    Price: $268/10mg
    Batatasin III

    Catalog No: CFN92689
    CAS No: 56684-87-8
    Price: $368/5mg
    Bruceoside A

    Catalog No: CFN95080
    CAS No: 63306-30-9
    Price: $318/5mg
    Columbianetin

    Catalog No: CFN90185
    CAS No: 3804-70-4
    Price: $268/20mg
    Licoricidin

    Catalog No: CFN96389
    CAS No: 30508-27-1
    Price: $388/5mg
    Pinoresinol

    Catalog No: CFN98775
    CAS No: 487-36-5
    Price: $268/20mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2805 mL 11.4025 mL 22.805 mL 45.61 mL 57.0125 mL
    5 mM 0.4561 mL 2.2805 mL 4.561 mL 9.122 mL 11.4025 mL
    10 mM 0.2281 mL 1.1403 mL 2.2805 mL 4.561 mL 5.7013 mL
    50 mM 0.0456 mL 0.2281 mL 0.4561 mL 0.9122 mL 1.1403 mL
    100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4561 mL 0.5701 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Leachianone A References Information
    Citation [1]

    Cancer Lett. 2007 Aug 18;253(2):224-35.

    Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.[Pubmed: 17379399]
    The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer. In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed. In conclusion, this is the first report describing the isolation of Leachianone A from Radix Sophorae and the molecular mechanism of its anti-proliferative effect on HepG2 cells.
    Citation [2]

    Journal of Huazhong Normal University, 2014,  48(4):520-4.

    Lavandulyl flavonoids with sodium-dependent glucose cotransporter 2 inhibitory activity from Sophora flavescens.[Reference: WebLink]
    To discover new bioactive Sodium-dependent glucose cotransporter 2(SGLT2)inhibitors from the traditional Chinese medicine"Ku Shen"(roots of Sophora flavescens),the bioassay-guided purification of an active ethyl acetate fraction was performed.Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),Leachianone A(14),kuraridine(15)and kushenol A(16).All isolated compounds exhibited inhibitory activity against SGLT2.Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively.
    Citation [3]

    Korean J. Oriental Physiology & Pathology,2008, 22(5):1163-7.

    Inhibitory Effects of Leachianone A from Sophora flavescens Ait. against Cadmium Induced Cytotoxicity.[Reference: WebLink]
    In this study, cytotoxicity of cadmium on NIH 3T fibroblasts was utilized in order to discover antitoxic compound in methanol extract of Sophora flavascens Ait. There were treatment groups; control (medium only), MTT50 group and five experimental groups. MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H- tetrazoliumbromide} assay was performed to evaluate the cytotoxicity of cell organelles and IC50 was also measured. Accordingly we have examined the detoxification effects of methanol extract of S. flavescens Ait. and Leachianone A (LA) on cadmium-treated NIH 3T3 fibroblasts (IC50= 12.5 μM) to observe morphological changes by the light microscopy. Both S. flavescens Ait. methanol extract and LA showed inhibitory effects on cadmium-induced cytotoxicity. Furthermore, LA showed dose-dependency in detoxication. From these results, it is conceivable to suggest that LA from S. flavescens Ait. methanol extract is a potential antitoxic agent.