Science | Nature | Cell | View More
Natural Products
Leachianone A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Leachianone A
Price: $218 / 5mg
CAS No.: 97938-31-3
Catalog No.: CFN97560
Molecular Formula: C26H30O6
Molecular Weight: 438.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Sophora flavescens.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $218 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Utah State University (USA)
  • Aarhus University (Denmark)
  • University of Illinois (USA)
  • Chiang Mai University (Thailand)
  • Universidad de Buenos Aires (Argentina)
  • Universidade Federal de Santa C... (Brazil)
  • Korea Intitute of Science and T... (Korea)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • National Cancer Institute (USA)
  • Molecular Biology Institute of ... (Spain)
  • University of Hawaii Cancer Center (USA)
  • More...
Package
Featured Products
Umckalin

Catalog No: CFN70362
CAS No: 43053-62-9
Price: $ / mg
(+)-Borneol

Catalog No: CFN70111
CAS No: 464-43-7
Price: $30/20mg
Cyanidin-3-O-sambubioside chloride

Catalog No: CFN92173
CAS No: 33012-73-6
Price: $643/10mg
Panaxadiol

Catalog No: CFN99981
CAS No: 19666-76-3
Price: $40/20mg
Vanillic acid

Catalog No: CFN99331
CAS No: 121-34-6
Price: $30/20mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Kaempferol 3,7-di-O-glucoside

Catalog No: CFN91159
CAS No: 25615-14-9
Price: $288/5mg
Pinocembrin chalcone

Catalog No: CFN96919
CAS No: 4197-97-1
Price: $/mg
Luteolin-7-O-glucuronide

Catalog No: CFN98512
CAS No: 29741-10-4
Price: $118/20mg
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. Leachianone A exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2); leachianone A also possesses a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment, its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways.
Targets: SGLT
In vitro:
Cancer Lett. 2007 Aug 18;253(2):224-35.
Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.[Pubmed: 17379399]
The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer.
METHODS AND RESULTS:
In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed.
CONCLUSIONS:
In conclusion, this is the first report describing the isolation of Leachianone A from Radix Sophorae and the molecular mechanism of its anti-proliferative effect on HepG2 cells.
Journal of Huazhong Normal University, 2014,  48(4):520-4.
Lavandulyl flavonoids with sodium-dependent glucose cotransporter 2 inhibitory activity from Sophora flavescens.[Reference: WebLink]
To discover new bioactive Sodium-dependent glucose cotransporter 2(SGLT2)inhibitors from the traditional Chinese medicine"Ku Shen"(roots of Sophora flavescens),the bioassay-guided purification of an active ethyl acetate fraction was performed.
METHODS AND RESULTS:
Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),Leachianone A(14),kuraridine(15)and kushenol A(16).All isolated compounds exhibited inhibitory activity against SGLT2.Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively.
Leachianone A Description
Source: The roots of Sophora flavescens.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Batatasin IV

Catalog No: CFN95319
CAS No: 60347-67-3
Price: $318/5mg
Ganoderenic acid G

Catalog No: CFN95517
CAS No: 120481-73-4
Price: $318/5mg
8-epi-Confertin

Catalog No: CFN95509
CAS No: 110115-60-1
Price: $318/5mg
(1E)-3-methoxy-8,12-epoxygermacra-...

Catalog No: CFN95219
CAS No: 1393342-06-7
Price: $413/5mg
Clemomandshuricoside B

Catalog No: CFN95302
CAS No: 905294-48-6
Price: $318/10mg
Notoptol

Catalog No: CFN95218
CAS No: 88206-49-9
Price: $318/5mg
Eriodictyol 7-O-glucuronide

Catalog No: CFN95290
CAS No: 125535-06-0
Price: $318/10mg
Rhamnetin 3-galactoside

Catalog No: CFN95116
CAS No: 62858-07-5
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2805 mL 11.4025 mL 22.805 mL 45.61 mL 57.0125 mL
5 mM 0.4561 mL 2.2805 mL 4.561 mL 9.122 mL 11.4025 mL
10 mM 0.2281 mL 1.1403 mL 2.2805 mL 4.561 mL 5.7013 mL
50 mM 0.0456 mL 0.2281 mL 0.4561 mL 0.9122 mL 1.1403 mL
100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4561 mL 0.5701 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Korean J. Oriental Physiology & Pathology,2008, 22(5):1163-7.
Inhibitory Effects of Leachianone A from Sophora flavescens Ait. against Cadmium Induced Cytotoxicity.[Reference: WebLink]
In this study, cytotoxicity of cadmium on NIH 3T fibroblasts was utilized in order to discover antitoxic compound in methanol extract of Sophora flavascens Ait.
METHODS AND RESULTS:
There were treatment groups; control (medium only), MTT50 group and five experimental groups. MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H- tetrazoliumbromide} assay was performed to evaluate the cytotoxicity of cell organelles and IC50 was also measured. Accordingly we have examined the detoxification effects of methanol extract of S. flavescens Ait. and Leachianone A (LA) on cadmium-treated NIH 3T3 fibroblasts (IC50= 12.5 μM) to observe morphological changes by the light microscopy. Both S. flavescens Ait. methanol extract and LA showed inhibitory effects on cadmium-induced cytotoxicity. Furthermore, LA showed dose-dependency in detoxication.
CONCLUSIONS:
From these results, it is conceivable to suggest that LA from S. flavescens Ait. methanol extract is a potential antitoxic agent.
Umckalin

Catalog No: CFN70362
CAS No: 43053-62-9
Price: $ / mg
(+)-Borneol

Catalog No: CFN70111
CAS No: 464-43-7
Price: $30/20mg
Cyanidin-3-O-sambubioside chloride

Catalog No: CFN92173
CAS No: 33012-73-6
Price: $643/10mg
Panaxadiol

Catalog No: CFN99981
CAS No: 19666-76-3
Price: $40/20mg
Vanillic acid

Catalog No: CFN99331
CAS No: 121-34-6
Price: $30/20mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Kaempferol 3,7-di-O-glucoside

Catalog No: CFN91159
CAS No: 25615-14-9
Price: $288/5mg
Pinocembrin chalcone

Catalog No: CFN96919
CAS No: 4197-97-1
Price: $/mg
Luteolin-7-O-glucuronide

Catalog No: CFN98512
CAS No: 29741-10-4
Price: $118/20mg
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Tags: buy Leachianone A | Leachianone A supplier | purchase Leachianone A | Leachianone A cost | Leachianone A manufacturer | order Leachianone A | Leachianone A distributor