Levistilide A | CAS:88182-33-6 | Manufacturer ChemFaces

Levistilide A

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Description:

Traditional formula compatibility of Danggui-Shaoyao-San could significantly enhance levistilide A bioavailability compared with levistilide A alone and Rhizoma Chuanxiong.

In vitro:

Cell Physiol Biochem . 2017;42(3):929-938.

Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells[Pubmed: 28662507]

Abstract Background/aims: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. In this study, we investigated the anticancer effect of LA in HCT116 and its isogenic p53-/- colon cancer cells, as well as the underlying mechanisms. Methods: MTT assay was used to evaluate the effect of LA on the viability of cancer cells. Apoptosis and reactive oxygen species (ROS) production by the cells were determined by flow cytometry. Protein expression was detected by western blotting. Results: The results showed that LA inhibited viability and caused apoptosis of both wild-type and p53-/- HCT116 cells. LA was able to trigger production of ROS and endoplasmic reticulum (ER) stress. Inhibition of ROS using N-acetylcysteine abrogated LA-induced ER stress and apoptosis, as well as the reduction in cancer cell viability. Conclusion: Our results indicate that LA causes apoptosis of colon cancer cells via ROS-mediated ER stress pathway. It will be interesting to develop the natural compound for chemotherapy of cancers such as CRC. Keywords: Apoptosis; ER stress; Levistolide A; ROS.

Levistilide A Description

Source:	The roots of Angelica sinensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Chromatogr Sci. 2015 Feb 5. pii: bmu224.

Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS.[Pubmed: 25657289]

A rapid sensitive analytical method was established and validated to investigate levistolide A in rat plasma by liquid chromatography-tandem mass spectrometry operated in the positive ion mode.
METHODS AND RESULTS:
Levistilide A (LA) and internal standard (IS) andrographolide (AD), mixed with the plasma sample, were separated on a reversed phase Spursil™ C18 5 μm column. The precursor/product transitions (m/z) were 398.5/381.3 for Levistilide A and (m/z) 368.0/351.1 for AD. The calibration curve was linear over the range from 5 to 1,250 ng/mL for oral administration and 10-4,000 for intravenous administration with a correlation coefficient (r) ≥0.9993. The lower limit of quantification was 5 ng/mL for Levistilide A in plasma. The inter- and intra-day accuracy and precision were less than ±15% of the relative standard deviation. In this study, the developed method is successfully applied to the comparative pharmacokinetic study of Levistilide A in rats after oral administration of Levistilide A alone, Rhizoma Chuanxiong, and Danggui-Shaoyao-San along with the bioavailability study of Levistilide A in rats.
CONCLUSIONS:
Our study shows that low bioavailability (7.5%) is observed after oral administration of Levistilide A .Traditional formula compatibility of Danggui-Shaoyao-San could significantly enhance Levistilide A bioavailability compared with Levistilide A alone and Rhizoma Chuanxiong.

Product Name	Levistilide A
Price:	$100 / 20mg
CAS No.:	88182-33-6
Catalog No.:	CFN99707
Molecular Formula:	C₂₄H₂₈O₄
Molecular Weight:	380.48 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Solid
Source:	The roots of Angelica sinensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-multidrug resistance Compound Library Miscellaneous Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6283 mL	13.1413 mL	26.2826 mL	52.5652 mL	65.7065 mL
5 mM	0.5257 mL	2.6283 mL	5.2565 mL	10.513 mL	13.1413 mL
10 mM	0.2628 mL	1.3141 mL	2.6283 mL	5.2565 mL	6.5706 mL
50 mM	0.0526 mL	0.2628 mL	0.5257 mL	1.0513 mL	1.3141 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	0.5257 mL	0.6571 mL

CFN95449	Senkyunolide N	140694-58-2	226.3	C₁₂H₁₈O₄
CFN99595	Senkyunolide H	94596-27-7	224.3	C₁₂H₁₆O₄
CFN99596	Senkyunolide I	94596-28-8	224.3	C₁₂H₁₆O₄
CFN95289	6-Hydroxy-7-methoxydihydroligustilide	210036-09-2	238.3	C₁₃H₁₈O₄
CFN95457	Riligustilide	89354-45-0	380.5	C₂₄H₂₈O₄
CFN93014	Angelicolide	90826-58-7	380.48	C₂₄H₂₈O₄
CFN99707	Levistilide A	88182-33-6	380.48	C₂₄H₂₈O₄
CFN90612	Tokinolide B	112966-16-2	380.48	C₂₄H₂₈O₄
CFN97868	(Z)-Lachnophyllum lactone	81122-95-4	162.2	C₁₀H₁₀O₂
CFN97885	Tetrahydrolachnophyllum lactone	56407-87-5	166.2	C₁₀H₁₄O₂