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    Ardisiacrispin A
    CAS No. 23643-61-0 Price $363 / 20mg
    Catalog No.CFN90177Purity>=98%
    Molecular Weight1061.21Type of CompoundTriterpenoids
    FormulaC52H84O22Physical DescriptionWhite powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Ardisiacrispin A has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM.
    2. Ardisiacrispin A and Ardisiacrispin B could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule.
    3. Ardisiacrispin(A+B) exhibits prominent abilities to inhibit the proliferation of HL-60 cells by blocking the cell cycle at S phase and inducing apoptosis.
    Targets: HSV
    Ardisiacrispin A Description
    Source: The herbs of Ardisia crenata.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9423 mL 4.7116 mL 9.4232 mL 18.8464 mL 23.558 mL
    5 mM 0.1885 mL 0.9423 mL 1.8846 mL 3.7693 mL 4.7116 mL
    10 mM 0.0942 mL 0.4712 mL 0.9423 mL 1.8846 mL 2.3558 mL
    50 mM 0.0188 mL 0.0942 mL 0.1885 mL 0.3769 mL 0.4712 mL
    100 mM 0.0094 mL 0.0471 mL 0.0942 mL 0.1885 mL 0.2356 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Ardisiacrispin A References Information
    Citation [1]

    J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):739-46.

    Pro-apoptotic and microtubule-disassembly effects of ardisiacrispin (A+B), triterpenoid saponins from Ardisia crenata on human hepatoma Bel-7402 cells.[Pubmed: 18696326]
    Ardisiacrispin A+Ardisiacrispin B is a mixture of Ardisiacrispin A and ardisiacrispin B, derived from Ardisia crenata with a fixed proportion (2:1). The present study was conducted to investigate its anticancer activity on human cancer cells and its underlying mechanism of action. The (IC50)s of Ardisiacrispin A+Ardisiacrispin B on proliferation of several human cancer cell lines were in the range of 0.9-6.5 microg/ml by sulphorhodamine B-based colorimetric assay, in which Bel-7402 was the most sensitive cell line. Moreover, Ardisiacrispin A+Ardisiacrispin B induced dose-dependent apoptosis in Bel-7402 cells at doses of 1-10 microg/ml by flow cytometry, and resulted in the changes of the mitochondrial membrane depolarization, membrane permeability enhancement, and nuclear condensation in a dose-dependent manner through high-content screening analysis. Furthermore, Ardisiacrispin A+Ardisiacrispin B could disassemble microtubule in Bel-7402 cells; the fluorescence intensity of microtubules decreased at the concentration of 5-20 microg/ml. These findings suggest that Ardisiacrispin A+Ardisiacrispin B could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule.
    Citation [2]

    Fitoterapia. 2011 Jul;82(5):782-5.

    A new triterpene saponin from Androsace integra.[Pubmed: 21497642]
    A new triterpene saponin, androsacin (1), along with two known compounds, Ardisiacrispin A (2) and saxifragifolin A (3), were isolated from the whole plants of Androsace integra. The chemical structure of the new compound was elucidated as 3β-O-{β-D-glucopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-[O-β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-16α-hydroxy-13β,28-epoxy-olean-30-al on the basis of spectral evidence. Ardisiacrispin A (2) was cytotoxic toward HepG2 cancer cell with the GI(50) value of 1.56μM.
    Citation [3]

    Chin. Pharm. Bull., 2007, 23(5):585-90.

    Study on inhibitory effects and mechanism of ardisiacrispin (A + B) on human promyeloleukemic HL-60 cells[Reference: WebLink]
    Aim: To study the inhibitory effect of Ardisiacrispin A+Ardisiacrispin B on human promyeloleukemic HL-60 cells and the underlying mechanism. Methods: Cell growth inhibition in vitro was evaluated with MTT assay. Ardisiacrispin A+Ardisiacrispin B -induced cell cycle block and apoptosis were investigated using flow cytometry assay. Apoptitic bodies were detected by PI staining. Western blot was applied to determine modification of certain protein related to apoptosis. Results: Ardisiacrispin A+Ardisiacrispin B displayed dose dependent growth inhibition ability on HL-60 cells with the IC50 value of 4.2 mg·L-1 for 48 h. Ardisiacrispin A+Ardisiacrispin B dose-dependently arrested HL-60 cells at the S phase of the cell cycle in the range of 1.0 - 5.0 mg·L-1, cells at S phase in treated group was 1.26inverted commas 1.46 and 1.71 times of control group for 6inverted commas24 and 48 h of incubation, respectively. Moreover, ardisiacrispin (A + B) induced dose-dependent apoptosis of HL-60 cells in the concentration of 1.0-7.5 mg·L-1. Furthermore, the PARP cleavage was detectable in a dose-dependent manner, 2.5 mg·L-1 Ardisiacrispin A+Ardisiacrispin B generated a 27.1% of lysis fraction for 24 h of incubation. Conclusion: Ardisiacrispin A+Ardisiacrispin B exhibits prominent abilities to inhibit the proliferation of HL-60 cells by blocking the cell cycle at S phase and inducing apoptosis.