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    CAS No. 147663-91-0 Price
    Catalog No.CFN96079Purity>=98%
    Molecular Weight827.0Type of CompoundLignans
    FormulaC54H50O8Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Magnolianin Description
    Source: The bark of Magnolia obovata
    Biological Activity or Inhibitors: 1. Magnolianin can inhibit strongly (IC50 = 0.45 uM) 5-HETE formation by die cytosol of guinea pig polymorphonuclear leukocytes.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2092 mL 6.0459 mL 12.0919 mL 24.1838 mL 30.2297 mL
    5 mM 0.2418 mL 1.2092 mL 2.4184 mL 4.8368 mL 6.0459 mL
    10 mM 0.1209 mL 0.6046 mL 1.2092 mL 2.4184 mL 3.023 mL
    50 mM 0.0242 mL 0.1209 mL 0.2418 mL 0.4837 mL 0.6046 mL
    100 mM 0.0121 mL 0.0605 mL 0.1209 mL 0.2418 mL 0.3023 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Magnolianin References Information
    Citation [1]

    Chem Pharm Bull (Tokyo). 2001 Jun;49(6):716-20.

    Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages.[Pubmed: 11411523]
    The methanolic extract from a Japanese herbal medicine, the bark of Magnolia obovata, was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages. By bioassay-guided separation, three neolignans (magnolol, honokiol, obovatol) and three sesquiterpenes (alpha-eudesmol, beta-eudesmol, gamma-eudesmol) were obtained as active constituents. A trineolignan (Magnolianin), a phenylpropanoid glycoside (syringin), lignan glycosides (liriodendrin, (+)-syringaresinol 4'-O-beta-D-glucopyranoside) and a sesquiterpene (caryophyllene oxide) did not show any activity.
    Citation [2]

    Tetrahedron Letters, 1993 , 34 (6) :1051-1054.

    Structure of Magnolianin, a novel trilignan possessing potent 5-lipoxygenase inhibitory activity[Reference: WebLink]
    Magnolianin, a novel trilignan with a 1, 4-benzodioxane ring, isolated from the bark of Magnolia obovata, has been assigned structure on the basis of extensive analysis of 2D 1H and 13C NMR of its triacetate derivative. Magnolianin has been found to inhibit strongly (IC50 = 0.45 μM) 5-HETE formation by die cytosol of guinea pig polymorphonuclear leukocytes.