• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    CAS No. 13710-70-8 Price $168 / 10mg
    Catalog No.CFN92712Purity>=98%
    Molecular Weight246.3Type of CompoundCoumarins
    FormulaC14H14O4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $76.4 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Funda??o Universitária de Dese... (Brazil)
  • Kazusa DNA Research Institute (Japan)
  • Utrecht University (Netherlands)
  • Universitas Airlangga (Indonesia)
  • University of Wisconsin-Madison (USA)
  • National Cancer Institute (USA)
  • University of the Basque Country (Spain)
  • Institute of Chinese Materia Me... (China)
  • University of Padjajaran (Indonesia)
  • Johannes Gutenberg University M... (Germany)
  • University of Illinois at Chicago (USA)
  • More...
  • Package
    Featured Products
    Terrestrosin K

    Catalog No: CFN90822
    CAS No: 193605-07-1
    Price: $218/10mg

    Catalog No: CFN96248
    CAS No: 79120-40-4
    Price: $368/5mg
    Dihydrocucurbitacin B

    Catalog No: CFN92140
    CAS No: 13201-14-4
    Price: $318/10mg

    Catalog No: CFN95003
    CAS No: N/A
    Price: $358/5mg
    Chamaejasmenin C

    Catalog No: CFN92061
    CAS No: 89595-70-0
    Price: $498/5mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg

    Catalog No: CFN92154
    CAS No: 69618-96-8
    Price: $463/5mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Antifungal Compound Library
  • Antiangiogenic Compound Library
  • Antifeedant Compound Library
  • Phytoalexin Compound Library
  • Coumarins Compound Library
  • Biological Activity
    Description: Marmesin has hepatoprotective potential; it also has cytotoxic with a 50% lethal dose of less than 0.5 micrograms/ml, is not as mutagenic or potentially carcinogenic as are AFB1, imperatorin, or MOP with BL activation.
    Targets: AST | ALT
    In vitro:
    Molecules. 2014 Oct 22;19(10):16959-75.
    Antioxidant, 5-lipoxygenase inhibitory and cytotoxic activities of compounds isolated from the Ferula lutea flowers.[Pubmed: 25340301]
    A phytochemical investigation of the Ferula lutea (Poir.) Maire flowers has led to the isolation of a new compound, (E)-5-ethylidenefuran-2(5H)-one-5-O-β-d-glucopyranoside (1), designated ferunide, 4-hydroxy-3-methylbut-2-enoic acid (2), reported for the first time as a natural product, together with nine known compounds, verbenone-5-O-β-d-glucopyranoside (3), 5-O-caffeoylquinic acid (4), methyl caffeate (5), methyl 3,5-O-dicaffeoylquinate (6), 3,5-O-dicaffeoylquinic acid (7), isorhamnetin-3-O-α-l-rhamnopyranosyl(1→6)-β-d-glucopyranoside, narcissin (8), (-)-Marmesin (9), isoimperatorin (10) and 2,3,6-trimethylbenzaldehyde (11).
    Compounds 3-10 were identified for the first time in Ferula genus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR experiments, mass spectroscopy and X-ray diffraction analysis (compound 2), as well as by comparison with literature data. The antioxidant, anti-inflammatory and cytotoxic activities of isolated compounds were evaluated. Results showed that compound 7 exhibited the highest antioxidant activity with IC50 values of 18 ± 0.5 μmol/L and 19.7 ± 0.7 μmol/L by DPPH radical and ABTS radical cation, respectively. The compound 6 exhibited the highest anti-inflammatory activity with an IC50 value of 5.3 ± 0.1 μmol/L against 5-lipoxygenase. In addition, compound 5 was found to be the most cytotoxic, with IC50 values of 22.5 ± 2.4 μmol/L, 17.8 ± 1.1 μmol/L and 25 ± 1.1 μmol/L against the HCT-116, IGROV-1 and OVCAR-3 cell lines, respectively.
    In vivo:
    J Pharm Pharmacol. 2012 Jun;64(6):888-96.
    Hepatoprotective activity of Feronia limonia root.[Pubmed: 22571268]
    The aim of this study was to evaluate the hepatoprotective potential of a methanolic extract and of Marmesin isolated from the root bark of Feronia limonia.
    Activity levels of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT), cell viability and cell death were evaluated in HepG2 cells (human liver hepatoma cells) treated with CCl₄ in the presence or absence of F. limonia extract or Marmesin. Plasma activity levels of AST, ALT, bilirubin, alkaline phosphatase, protein, hepatic antioxidants, lipid peroxidation and histopathological evaluations were carried out in rats treated with CCl₄ alone or co-supplemented with F. limonia extract or Marmesin in a dose-dependent manner. In-vitro co-supplementation of F. limonia methanolic extract or Marmesin significantly minimized alteration in levels of AST and ALT and improved cell viability. Oral administration of F. limonia methanolic extract or Marmesin significantly prevented CCl₄-induced elevation in the plasma markers of hepatic damage and hepatic lipid peroxidation and a decrease in hepatic antioxidants. In-vivo hepatoprotective potential of F. limonia methanolic extract and Marmesin was evident from the minimal alterations in the histoarchitecture of liver.
    This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and Marmesin.
    Marmesin Description
    Source: The roots of Notopterygium incisum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Angelol H

    Catalog No: CFN91925
    CAS No: 83247-73-8
    Price: $338/5 mg
    Rhamnocitrin 3-glucoside

    Catalog No: CFN95134
    CAS No: 41545-37-3
    Price: $318/10mg

    Catalog No: CFN95142
    CAS No: 58970-69-7
    Price: $368/5mg
    Ginsenoside MC

    Catalog No: CFN95232
    CAS No: 175484-06-7
    Price: $318/10mg

    Catalog No: CFN95234
    CAS No: 858127-38-5
    Price: $318/5mg
    Bruceantinol B

    Catalog No: CFN95216
    CAS No: 1822332-33-1
    Price: $318/5mg
    Ginsenoside Rd2 (Quinquenoside L10...

    Catalog No: CFN95231
    CAS No: 83480-64-2
    Price: $318/10mg
    Dehydrotrametenolic acid

    Catalog No: CFN90577
    CAS No: 29220-16-4
    Price: $268/20mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
    5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
    10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Cell Research:
    Cancer Res. 1983 Mar;43(3):1054-8.
    Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants.[Pubmed: 6402296]

    Mutation by aflatoxin B1 (AFB1), imperatorin, Marmesin, chalepin, and 8-methoxypsoralen (MOP), with and without black light (BL; long-wavelength ultraviolet light) activation, was determined at the hypoxanthine-guanine phosphoribosyltransferase locus (8-azaguanine resistance) in Chinese hamster V79 cells and at the ouabain locus in mouse C3H/1OT1/2 cells. Transformation by these furocoumarins under the same activation conditions was also investigated in C3H/1OT1/2 cells. In V79 cells, AFB1 induced a 4-fold maximum mutation frequency over controls under BL activation at a concentration of 5 micrograms/ml; Marmesin induced a 2-fold increased mutation frequency at 1.5 micrograms/ml; MOP induced a 19-fold increase at 10 micrograms/ml; chalepin induced a 3-fold increase at 5 micrograms/ml; and imperatorin induced a 20-fold increase at 10 micrograms/ml. Essentially no mutation was observed at the ouabain-resistant (Ouar) locus in C3H/1OT1/2 cells with any of these compounds. In the transformation assays, type II and type III foci were observed at a 1-microgram/ml addition of AFB1 with or without BL activation; while with MOP and imperatorin, these types of foci were observed only with BL activation. Marmesin, although relatively more cytotoxic than the other furocoumarins studied, with a 50% lethal dose of less than 0.5 micrograms/ml, was not as mutagenic or potentially carcinogenic as were AFB1, imperatorin, or MOP with BL activation.
    These furocoumarins are considered to be involved in the etiology of the high incidence of skin cancer in Nigeria. Our experiments reinforce that concept and suggest that exposure to these furocoumarins may constitute a real carcinogenic hazard.