ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Fitoterapia.2015, 100:179-86Sci Rep.2015, 5:13194Food Sci Biotechnol....2016...Int J Mol Med.2016, 37(2):501-8Acta horticulturae2017, 1158:257-268Pharmacognosy Magazine...2017...Sci Rep. 2017, 17332(7)J Ethnopharmacol.2017, 206:73-77
J Agric Food Chem....2017...J Nat Prod.2017, 80(4):854-863Sci Rep. 2017, 8207(7)Phytother Res.2018, 32(5):923-932Phytomedicine.2018, 38:45-56J of the Society of Cosmetic Scie...2018...Pathogens.2018, 7(3):E62Postharvest Biol Tec2019, 149:18-26
Int J Mol Sci.2019, 20(11):E2734Int J Mol Sci.2019, 20(3):E651J Med Food.2019, 22(10):1067-1077The Malaysian journal of patholog...2019...J Asian Nat Prod Res.2019, 5:1-17Anal Biochem.2019, 569:10-15Br J Pharmacol.2020, 10.1111
Our products had been exported to the following research institutions and universities, And still growing.
University of Pretoria (South Africa)Kazusa DNA Research Institute (Japan)Kamphaengphet Rajabhat University (Thailand)VIT University (India)
University of Vigo (Spain)University of Limpopo (South Africa)Stanford University (USA)University of the Basque Country (Spain)
University of Beira Interior (Portugal)Aarhus University (Denmark)Srinakharinwirot University (Thailand)
Related Screening Libraries
|| Methyl 3-carbazolecarboxylate is a natural product from Micromelum sp.|
||Immunology & Inflammation related|
|Planta Med. 2005 Mar;71(3):261-7. |
|Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.[Pubmed: 15770548 ]|
METHODS AND RESULTS:
Anti-TB bioassay-directed fractionation led to the isolation of six carbazole alkaloids, as well as the gamma-lactone derivative of oleic acid, from the CH (2)Cl (2) extract of the stem bark of Micromelum hirsutum. The carbazoles include the new micromeline ( 2) and five known alkaloids: lansine ( 3), 3-methylcarbazole ( 4), methyl carbazole-3-carboxylate ( Methyl 3-carbazolecarboxylate,5), 3-formylcarbazole ( 6), and 3-formyl-6-methoxycarbazole ( 7). Compound 1 was identified as the lactone derivative of oleic acid, (-)- Z-9-octadecene-4-olide, for which the trivial name micromolide ( 1) is suggested. It showed potent in vitro anti-TB activity against H37R v (MIC: 1.5 microg/mL), a selectivity index (SI) of 63, and exhibited activity against the Erdman strain of M. tuberculosis in a J774 mouse macrophage model (EC (90) : 5.6 microg/mL).
Thus, 1 appears worthy of further evaluation as a potential new anti-TB agent. Isolates 2, 3, 6 and 7 had anti-TB MIC values between 14.3 and 42.3 microg/mL, while compounds 4 and 5 were considered inactive (MIC > 128 microg/mL). Structure elucidation and identification were based on spectroscopic analysis, including MS, 1D/2D NMR, and a full (1)H spin system analysis of 1.
Methyl 3-carbazolecarboxylate Description
||The herbs of Micromelum sp.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.