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Methyl 3-carbazolecarboxylate
Methyl 3-carbazolecarboxylate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Methyl 3-carbazolecarboxylate
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CAS No.: 97931-41-4
Catalog No.: CFN97559
Molecular Formula: C14H11NO2
Molecular Weight: 225.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The herbs of Micromelum sp.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Methyl 3-carbazolecarboxylate is a natural product from Micromelum sp.
Targets: Immunology & Inflammation related
In vitro:
Planta Med. 2005 Mar;71(3):261-7.
Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.[Pubmed: 15770548 ]

METHODS AND RESULTS:
Anti-TB bioassay-directed fractionation led to the isolation of six carbazole alkaloids, as well as the gamma-lactone derivative of oleic acid, from the CH (2)Cl (2) extract of the stem bark of Micromelum hirsutum. The carbazoles include the new micromeline ( 2) and five known alkaloids: lansine ( 3), 3-methylcarbazole ( 4), methyl carbazole-3-carboxylate ( Methyl 3-carbazolecarboxylate,5), 3-formylcarbazole ( 6), and 3-formyl-6-methoxycarbazole ( 7). Compound 1 was identified as the lactone derivative of oleic acid, (-)- Z-9-octadecene-4-olide, for which the trivial name micromolide ( 1) is suggested. It showed potent in vitro anti-TB activity against H37R v (MIC: 1.5 microg/mL), a selectivity index (SI) of 63, and exhibited activity against the Erdman strain of M. tuberculosis in a J774 mouse macrophage model (EC (90) : 5.6 microg/mL).
CONCLUSIONS:
Thus, 1 appears worthy of further evaluation as a potential new anti-TB agent. Isolates 2, 3, 6 and 7 had anti-TB MIC values between 14.3 and 42.3 microg/mL, while compounds 4 and 5 were considered inactive (MIC > 128 microg/mL). Structure elucidation and identification were based on spectroscopic analysis, including MS, 1D/2D NMR, and a full (1)H spin system analysis of 1.
Methyl 3-carbazolecarboxylate Description
Source: The herbs of Micromelum sp.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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IF=22.415(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4405 mL 22.2025 mL 44.405 mL 88.8099 mL 111.0124 mL
5 mM 0.8881 mL 4.4405 mL 8.881 mL 17.762 mL 22.2025 mL
10 mM 0.444 mL 2.2202 mL 4.4405 mL 8.881 mL 11.1012 mL
50 mM 0.0888 mL 0.444 mL 0.8881 mL 1.7762 mL 2.2202 mL
100 mM 0.0444 mL 0.222 mL 0.444 mL 0.8881 mL 1.1101 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Ganoderic acid K

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CAS No: 104700-95-0
Price: $318/5mg
Sesamoside

Catalog No: CFN99274
CAS No: 117479-87-5
Price: $100/20mg
Rutaecarpine

Catalog No: CFN97337
CAS No: 84-26-4
Price: $40/20mg
Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg
Procyanidin A1

Catalog No: CFN96495
CAS No: 103883-03-0
Price: $288/20mg
Aromadendrene

Catalog No: CFN95074
CAS No: 489-39-4
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Inotodiol

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CAS No: 35963-37-2
Price: $338/5mg
Coumarin

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Hederacoside C

Catalog No: CFN90183
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Price: $40/20mg
Amygdalin

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Price: $30/20mg
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