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    Methyl 3-carbazolecarboxylate
    Methyl 3-carbazolecarboxylate
    Information
    CAS No. 97931-41-4 Price
    Catalog No.CFN97559Purity>=98%
    Molecular Weight225.2 Type of CompoundAlkaloids
    FormulaC14H11NO2Physical DescriptionYellow powder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Methyl 3-carbazolecarboxylate is a natural product from Micromelum sp.
    Targets: Immunology & Inflammation related
    In vitro:
    Planta Med. 2005 Mar;71(3):261-7.
    Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.[Pubmed: 15770548 ]

    METHODS AND RESULTS:
    Anti-TB bioassay-directed fractionation led to the isolation of six carbazole alkaloids, as well as the gamma-lactone derivative of oleic acid, from the CH (2)Cl (2) extract of the stem bark of Micromelum hirsutum. The carbazoles include the new micromeline ( 2) and five known alkaloids: lansine ( 3), 3-methylcarbazole ( 4), methyl carbazole-3-carboxylate ( Methyl 3-carbazolecarboxylate,5), 3-formylcarbazole ( 6), and 3-formyl-6-methoxycarbazole ( 7). Compound 1 was identified as the lactone derivative of oleic acid, (-)- Z-9-octadecene-4-olide, for which the trivial name micromolide ( 1) is suggested. It showed potent in vitro anti-TB activity against H37R v (MIC: 1.5 microg/mL), a selectivity index (SI) of 63, and exhibited activity against the Erdman strain of M. tuberculosis in a J774 mouse macrophage model (EC (90) : 5.6 microg/mL).
    CONCLUSIONS:
    Thus, 1 appears worthy of further evaluation as a potential new anti-TB agent. Isolates 2, 3, 6 and 7 had anti-TB MIC values between 14.3 and 42.3 microg/mL, while compounds 4 and 5 were considered inactive (MIC > 128 microg/mL). Structure elucidation and identification were based on spectroscopic analysis, including MS, 1D/2D NMR, and a full (1)H spin system analysis of 1.
    Methyl 3-carbazolecarboxylate Description
    Source: The herbs of Micromelum sp.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4405 mL 22.2025 mL 44.405 mL 88.8099 mL 111.0124 mL
    5 mM 0.8881 mL 4.4405 mL 8.881 mL 17.762 mL 22.2025 mL
    10 mM 0.444 mL 2.2202 mL 4.4405 mL 8.881 mL 11.1012 mL
    50 mM 0.0888 mL 0.444 mL 0.8881 mL 1.7762 mL 2.2202 mL
    100 mM 0.0444 mL 0.222 mL 0.444 mL 0.8881 mL 1.1101 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.