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More articles cited ChemFaces products.
J. Agric. Food Chem.,2015, 63 (44), 9869–9878Pharm Biol. 2015 Oct 1Inflammation. 2015 Feb 6.Universidade Estadual Paulista2017-02-19J. of The Korean Society of Food CultureApr.2017;
Clin Exp Pharmacol Physiol.2015 Aug 1Phytomedicine. 2017 Jan 15;J Ethnopharmacol. 2017 Jul 12;Biochem Systematics and EcologyOctober 2017;Food Science and Bio.31 October 2016
Biofactors.2017 Oct 24.BMC Complement Altern Med.2014 Sep 23;14:352.Molecules 2016, 21(6), 739;2016 Jun 14;21(6). Institute of Materia Medica2016 Mar 31, pp.29-35
Our products had been exported to the following research institutions and universities, And still growing.
University of Sao Paulo (Brazil)Julius Kühn-Institut (Germany)MTT Agrifood Research Finland (Finland)Wroclaw Medical University (Poland)
Medizinische Universit?t Wien (Austria)Georgia Institute of Technology (USA)Shanghai University of TCM (China)Sanford Burnham Prebys Medical D... (USA)
Universidad de Antioquia (Colombia)University Medical Center Mainz (Germany)Korea Institute of Oriental Medi... (Korea)
||Monotropein has anti-antiosteoporosis and anti-inflammatory activities, it exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes and can increase osteoblastic bone formation and prevent bone loss in ovariectomized mice.|
||MMP(e.g.TIMP) | IL Receptor | NOS | COX | TNF-α | NF-kB|
|Int Immunopharmacol. 2014 Dec;23(2):575-80. |
|Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes.[Pubmed: 25466264]|
|Osteoarthritis, characterized by a loss of articular cartilage accompanied with inflammation, is the most common age-associated degenerative disease. Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.
METHODS AND RESULTS:
In the present study, Monotropein was firstly to exhibit cartilage protective activity by down regulating the pro-inflammatory cytokines in the knee synovial fluid in vivo. The anti-apoptotic and anti-catabolic effects of Monotropein on rat OA chondrocytes treated by IL-1β were investigated in vitro. In cultured chondrocytes, Monotropein attenuated apoptosis in a dose-dependent manner in response to IL-1β stimulation. Moreover, treatment with Monotropein, the expressions of MMP-3 and MMP-13 were significantly decreased, the expression of COL2A1 was increased.
Taken together, these findings suggested that Monotropein exerted anti-apoptosis and anti-catabolic activity in chondrocytes, which might support its possible therapeutic role in OA.
|Food Chem Toxicol. 2013 Mar;53:263-71. |
|Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation.[Pubmed: 23261679]|
|We previously demonstrated that Monotropein isolated from the roots of Morinda officinalis (Rubiaceae) has anti-inflammatory effects in vivo.
METHODS AND RESULTS:
In the present study, we investigated the molecular mechanisms underlying the anti-inflammatory effects of Monotropein in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein was found to inhibit the expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) mRNA in LPS-induced RAW 264.7 macrophages. Treatment with Monotropein decreased the DNA binding activity of nuclear factor-κB (NF-κB). Consistent with these findings, Monotropein also suppressed phosphorylation and degradation of inhibitory κB-α (IκB-α), and consequently the translocations of NF-κB. In the DSS-induced colitis model, Monotropein reduced disease activity index (DAI), myeloperoxidase (MPO) activity, and inflammation-related protein expressions by suppressing NF-κB activation in colon mucosa.
Taken together, these findings suggest that the anti-inflammatory effects of Monotropein are mainly related to the inhibition of the expressions of inflammatory mediators via NF-κB inactivation, and support its possible therapeutic role in colitis.
|Fitoterapia. 2016 Apr;110:166-72. |
|Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice.[Pubmed: 26996879]|
|Monotropein is a natural iridoid glycoside enriched in Morinda officinalis and has been used for medicinal purposes in China.
METHODS AND RESULTS:
In the present study, we systematically examined its effects on ovariectomy (OVX)-induced osteoporosis in mice and osteoblastic MC3T3-E1 cells for the first time. Eight-week-old female C57/BL6 mice were used to evaluate the osteoprotective effect of Monotropein. Results showed that administration of Monotropein (40 or 80 mg/kg/day) for four weeks exerted good bone protective effects as evidenced by the increase of bone mineral content (BMC), bone mineral density (BMD), bone volume fraction (BVF) and improvement of bone microstructure. Monotropein also enhanced the parameters of biomechanical properties, including maximum load, maximum stress and elastic modulus of femur in OVX mice. In addition, Monotropein treatment decreased the serum levels of interleukin 1 (IL-1), interleukin 6 (IL-6) and soluble receptor activator of NF-κB ligand (sRANKL) in OVX mice. In this study, we also assessed the effects of Monotropein on the proliferation and differentiation of osteoblastic MC3T3-E1 cells in vitro. After incubation for 48h, the cell proliferation was increased at the concentration of 10 μM, 25 μM, 50 μM and 100 μM. ALP activities were significantly increased after treatment with Monotropein for 72h. Quantitative analyses with alizarin red staining showed significantly increased mineralization of MC3T3-E1 cells after treatment with Monotropein for 28 days.
Based on these results, Monotropein may serve as a new candidate or a leading compound for antiosteoporosis.
||The roots of Morinda officinalis How.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Biol Pharm Bull. 2005 Oct;28(10):1915-8. |
|Antinociceptive anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis.[Pubmed: 16204945]|
|The root of Morinda officinalis (Rubiaceae) is used to treat rheumatoid arthritis and impotence in the traditional Oriental medicine. To identify the antinociceptive anti-inflammatory components of this crude drug, we adopted an activity-directed fractionation approach.
METHODS AND RESULTS:
The active fraction of the BuOH extract of M. officinalis root was subjected to silica gel and ODS column chromatography to yield two diterpenes, compounds 1 and 2 and these were identified as Monotropein and deacetylasperulosidic acid, respectively. The iridoid glycoside, Monotropein, was tested for its anti-inflammatory antinociceptive effects using hot plate- and writhing antinociceptive assays and by using carrageenan-induced anti-inflammatory assays in mice and rats. Pretreatment with Monotropein (at 20, 30 mg/kg/d, p.o.) significantly reduced stretching episodes and prolonged action time in mice. It also significantly reduced acute paw edema by carrageenan in rats.
These results indicate that Monotropein contributes to the antinociceptive and anti-inflammatory action of Morinda officinalis root.