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    N-Methyltaxol C
    N-Methyltaxol C
    Information
    CAS No. 153083-53-5 Price
    Catalog No.CFN89043Purity>=98%
    Molecular Weight861.97Type of CompoundDiterpenoids
    FormulaC47H59NO14Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolated heart.
    In vitro:
    J Pharmacol Exp Ther. 1998 Feb;284(2):561-7.
    Differential effects of paclitaxel and derivatives on guinea pig isolated heart and papillary muscle.[Pubmed: 9454798]
    Paclitaxel (Taxol) is an anticancer agent with clinical activity against various human cancer types.
    METHODS AND RESULTS:
    Paclitaxel blocks cell division by stabilizing microtubules, a mechanism that also underlies its major side effects (neutropenia and neurotoxicity). Paclitaxel can also alter cardiac function, and to elucidate the mechanism of this activity, we tested the mechanical and electrical effects of paclitaxel and a series of analogs (docetaxel, taxol B, taxol C and N-Methyltaxol C; 5-20 microM) on two different cardiac preparations, the isolated coronary perfused heart and the papillary muscle of the guinea pig. Paclitaxel and N-Methyltaxol C induced conduction arrhythmias and reduced coronary flow and left ventricular systolic pressure in the isolated heart, whereas the other taxol derivatives tested had no significant effect. Moreover, paclitaxel blocked the vasodilator effect of bradykinin in the isolated heart. Paclitaxel and N-Methyltaxol C produced a positive inotropic effect in papillary muscle, without alterations in the action potential. In the latter preparation, no significant variations were observed after treatment with the other taxol derivatives.
    CONCLUSIONS:
    The in vitro cardiodepressant and arrhythmogenic activity of paclitaxel is similar to that reported after its clinical administration and might be due to coronary vasoconstriction. The precise role of microtubules as modulators of intracellular calcium in cardiac and smooth muscle cells is at present unclear, because docetaxel and other taxol analogs, though they exhibited similar activity on tubulin, lacked cardiac effects.
    N-Methyltaxol C Description
    Source: The branches of Taxus Chinensis var.Mairei.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1601 mL 5.8007 mL 11.6013 mL 23.2027 mL 29.0033 mL
    5 mM 0.232 mL 1.1601 mL 2.3203 mL 4.6405 mL 5.8007 mL
    10 mM 0.116 mL 0.5801 mL 1.1601 mL 2.3203 mL 2.9003 mL
    50 mM 0.0232 mL 0.116 mL 0.232 mL 0.4641 mL 0.5801 mL
    100 mM 0.0116 mL 0.058 mL 0.116 mL 0.232 mL 0.29 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Org Chem. 2008 Jun 20;73(12):4705-8.
    N-methylation of the c3' amide of taxanes: synthesis of N-methyltaxol C and N-methylpaclitaxel.[Pubmed: 18498195 ]
    A method has been developed for the methylation of the C3' amide of taxol C and paclitaxel.
    METHODS AND RESULTS:
    Taxol C and paclitaxel were sequentially silylated at the 2', 7, and 1-hydroxyl groups with tert-butyldimethylsilyl chloride, triethylsilyl chloride, and dimethylsilyl chloride, respectively. Subsequent reaction with potassium tert-butoxide and methyl iodide provided the corresponding N-methylated taxane derivatives. Removal of the silyl protecting groups furnished N-Methyltaxol C and N-methylpaclitaxel.