ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
The Japan Society for Analy. Chem.2017 Nov. 8;Biochem Pharmacol. 2017 Apr 15;J. Agric. Food Chem.,2015, 63 (44), 9869–9878J Basic Clin Physiol Pharmacol.2015 Aug 15J. Acta Agr. Scandinavica17 Apr 2017
Korean j.of Pharm.Dec.2017;Hum Exp Toxicol. 2016 Dec 9.Korean J. of Food Sci. and TechApril 2016Tumour Biol.2015 Apr 12.Horticultural Science2016
Oncol Rep.2015 Dec 22. Sci Rep. 2018 Jan 11;JPCJuly 12, 2017Org Biomol Chem. 2017 Jul 25.
Our products had been exported to the following research institutions and universities, And still growing.
Regional Crop Research Institute (Korea)Institute of Tropical Disease Un... (Indonesia)Warszawski Uniwersytet Medyczny (Poland)University of British Columbia (Canada)
The Vancouver Prostate Centre (V... (Canada)Heinrich-Heine-University Düsse... (Germany)Kazusa DNA Research Institute (Japan)University of Hertfordshire (United Kingdom)
National Cancer Center Research ... (Japan)National Chung Hsing University (Taiwan)Texas A&M University (USA)
||The roots of Scutellaria baicalensis Georgi
|Biological Activity or Inhibitors:
||1. Norwogonin shows potent inhibitory activity toward VHR.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Norwogonin References Information
Planta Med. 2002 Dec;68(12):1063-5.
|Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]|
|Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC 50 = 1.1 microM), dihydroNorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.