• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Pachyaximine A
    Pachyaximine A
    Information
    CAS No. 128255-08-3 Price
    Catalog No.CFN99385Purity>=98%
    Molecular Weight359.6 Type of CompoundAlkaloids
    FormulaC24H41NOPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Imperial College London (United Kingdom)
  • Semmelweis Unicersity (Hungary)
  • University of Toulouse (France)
  • Wroclaw Medical University (Poland)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Sri Sai Aditya Institute of Pha... (India)
  • Uniwersytet Gdański (Poland)
  • Worcester Polytechnic Institute (USA)
  • Biotech R&D Institute (USA)
  • Kyoto University (Japan)
  • Universidade Federal de Goias (... (Brazil)
  • More...
  • Package
    Featured Products
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    Ganoderenic acid D

    Catalog No: CFN90300
    CAS No: 100665-43-8
    Price: $476/10mg
    Nodakenin

    Catalog No: CFN90232
    CAS No: 495-31-8
    Price: $138/20mg
    Glycitin

    Catalog No: CFN99105
    CAS No: 40246-10-4
    Price: $70/20mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Oroxylin A 7-O-beta-D-glucuronide

    Catalog No: CFN90191
    CAS No: 36948-76-2
    Price: $318/20mg
    cis-Mulberroside A

    Catalog No: CFN95006
    CAS No: 166734-06-1
    Price: $418/10mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antibacterial Compound Library
  • Anti-estrogenic effect Compound Library
  • Alkaloids Compound Library
  • Progestogen receptor Inhibitor Library
  • Estrogen receptor Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS)-inhibitory agents, and potentiates significantly the antiestrogenic effect mediated by tamoxifen in cultured Ishikawa cells.
    Targets: Estrogen receptor | Antifection | Progestogen receptor
    In vitro:
    Pak J Pharm Sci. 2005 Apr;18(2):3-5.
    Anti-bacterial alkaloids of Saracococca saligna.[Pubmed: 16431389]

    METHODS AND RESULTS:
    The crude ethanolic extract of Saracococca saligna was found to be cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of two known alkaloid, pachyaximine-A and saracodine was determined.
    CONCLUSIONS:
    Pachyaximine-A possessed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. Saracodme showed moderate activity against Staphylococcus pyrogenes, Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae, Shigella boydii and Klebsiella pneumoniae.
    J Nat Prod. 1998 Oct;61(10):1257-62.
    Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.[Pubmed: 9784163 ]

    METHODS AND RESULTS:
    Four novel steroidal alkaloids, (+)-(20S)-20-(dimethylamino)-3-(3'alpha-isopropyl)-lactam-5alpha-+ ++preg n-2-en-4-one (1), (+)-(20S)-20-(dimethylamino)-16alpha-hydroxy-3-(3'alpha-isopropyl) -la ctam-5alpha-pregn-2-en-4-one (2), (+)-(20S)-3-(benzoylamino)-20-(dimethylamino)-5alpha-pregn-2-en-++ +4beta -yl acetate (3), and (+)-(20S)-2alpha-hydroxy-20-(dimethylamino)-3beta-phthalimido-5 alpha- pregnan-4beta-yl acetate (4), as well as five known compounds, (-)-Pachyaximine A (5), (+)-spiropachysine (6), (+)-axillaridine A (7), (+)-epipachysamine D (8), and (+)-pachysamine B (9), were isolated from Pachysandra procumbens, using a bioassay-guided fractionation based on inhibition of 3H-tamoxifen binding at the antiestrogen binding site (AEBS).
    CONCLUSIONS:
    Compounds 1-7 and 9 demonstrated significant activity as AEBS-inhibitory agents, and compounds 3, 5 and 9 were found to potentiate significantly the antiestrogenic effect mediated by tamoxifen in cultured Ishikawa cells. The structure elucidation of compounds 1-4 was carried out by spectral data interpretation.
    Pachyaximine A Description
    Source: The herbs of Pachysandra axillaris
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Emodin-8-O-beta-gentiobioside

    Catalog No: CFN95132
    CAS No: 66466-22-6
    Price: $368/5mg
    Torosachrysone 8-O-beta-gentiobios...

    Catalog No: CFN95131
    CAS No: 94356-13-5
    Price: $318/5mg
    Isololiolide

    Catalog No: CFN95106
    CAS No: 38274-00-9
    Price: $388/5mg
    Isomucronulatol

    Catalog No: CFN90839
    CAS No: 52250-35-8
    Price: $218/10mg
    1-Phenyl-2-propanol

    Catalog No: CFN95129
    CAS No: 14898-87-4
    Price: $50/20mg
    Macrophylloside D

    Catalog No: CFN95113
    CAS No: 179457-69-3
    Price: $318/10mg
    Caraganaphenol A

    Catalog No: CFN95093
    CAS No: 174916-31-5
    Price: $333/5mg
    Ampelopsin F

    Catalog No: CFN92340
    CAS No: 151487-08-0
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7809 mL 13.9043 mL 27.8087 mL 55.6174 mL 69.5217 mL
    5 mM 0.5562 mL 2.7809 mL 5.5617 mL 11.1235 mL 13.9043 mL
    10 mM 0.2781 mL 1.3904 mL 2.7809 mL 5.5617 mL 6.9522 mL
    50 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.1123 mL 1.3904 mL
    100 mM 0.0278 mL 0.139 mL 0.2781 mL 0.5562 mL 0.6952 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.