• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Pachyaximine A
    Pachyaximine A
    Information
    CAS No. 128255-08-3 Price
    Catalog No.CFN99385Purity>=98%
    Molecular Weight359.6 Type of CompoundAlkaloids
    FormulaC24H41NOPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Uniwersytet Jagielloński w Krak... (Poland)
  • Instituto de Investigaciones Agr... (Chile)
  • University of Helsinki (Finland)
  • University of Mysore (India)
  • Instytut Nawozów Sztucznych w P... (Poland)
  • Imperial College London (United Kingdom)
  • Worcester Polytechnic Institute (USA)
  • Griffith University (Australia)
  • Mendel University in Brno (Czech Republic)
  • Universidad de La Salle (Mexico)
  • National Research Council of Can... (Canada)
  • More...
  • Package
    Featured Products
    Acteoside

    Catalog No: CFN97048
    CAS No: 61276-17-3
    Price: $60/20mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $413/5mg
    Gnetol

    Catalog No: CFN92425
    CAS No: 86361-55-9
    Price: $388/5mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    Biological Activity
    Description: 1. Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes.
    2. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS)-inhibitory agents, and potentiates significantly the antiestrogenic effect mediated by tamoxifen in cultured Ishikawa cells.
    Targets: Estrogen receptor | Antifection | Progestogen receptor
    Pachyaximine A Description
    Source: The herbs of Pachysandra axillaris
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Licoisoflavone A

    Catalog No: CFN90816
    CAS No: 66056-19-7
    Price: $596/10mg
    Pachymic acid

    Catalog No: CFN99590
    CAS No: 29070-92-6
    Price: $268/20mg
    Poricoic acid G

    Catalog No: CFN95056
    CAS No: 415724-84-4
    Price: $318/5mg
    1,3,6-Tri-O-galloylglucose

    Catalog No: CFN95043
    CAS No: 18483-17-5
    Price: $338/10mg
    3-Methoxyshancigusin I

    Catalog No: CFN95062
    CAS No: N/A
    Price: $413/5mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $268/20mg
    vibo-Quercitol

    Catalog No: CFN98778
    CAS No: 488-76-6
    Price: $218/20mg
    Neoglycyrol

    Catalog No: CFN90792
    CAS No: 23013-84-5
    Price: $398/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7809 mL 13.9043 mL 27.8087 mL 55.6174 mL 69.5217 mL
    5 mM 0.5562 mL 2.7809 mL 5.5617 mL 11.1235 mL 13.9043 mL
    10 mM 0.2781 mL 1.3904 mL 2.7809 mL 5.5617 mL 6.9522 mL
    50 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.1123 mL 1.3904 mL
    100 mM 0.0278 mL 0.139 mL 0.2781 mL 0.5562 mL 0.6952 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Pachyaximine A References Information
    Citation [1]

    Pak J Pharm Sci. 2005 Apr;18(2):3-5.

    Anti-bacterial alkaloids of Saracococca saligna.[Pubmed: 16431389]
    The crude ethanolic extract of Saracococca saligna was found to be cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of two known alkaloid, Pachyaximine A and saracodine was determined. Pachyaximine A possessed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. Saracodme showed moderate activity against Staphylococcus pyrogenes, Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae, Shigella boydii and Klebsiella pneumoniae.
    Citation [2]

    J Nat Prod. 1998 Oct;61(10):1257-62.

    Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.[Pubmed: 9784163 ]
    Four novel steroidal alkaloids, (+)-(20S)-20-(dimethylamino)-3-(3'alpha-isopropyl)-lactam-5alpha-+ ++preg n-2-en-4-one (1), (+)-(20S)-20-(dimethylamino)-16alpha-hydroxy-3-(3'alpha-isopropyl) -la ctam-5alpha-pregn-2-en-4-one (2), (+)-(20S)-3-(benzoylamino)-20-(dimethylamino)-5alpha-pregn-2-en-++ +4beta -yl acetate (3), and (+)-(20S)-2alpha-hydroxy-20-(dimethylamino)-3beta-phthalimido-5 alpha- pregnan-4beta-yl acetate (4), as well as five known compounds, (-)-Pachyaximine A (5), (+)-spiropachysine (6), (+)-axillaridine A (7), (+)-epipachysamine D (8), and (+)-pachysamine B (9), were isolated from Pachysandra procumbens, using a bioassay-guided fractionation based on inhibition of 3H-tamoxifen binding at the antiestrogen binding site (AEBS). Compounds 1-7 and 9 demonstrated significant activity as AEBS-inhibitory agents, and compounds 3, 5 and 9 were found to potentiate significantly the antiestrogenic effect mediated by tamoxifen in cultured Ishikawa cells. The structure elucidation of compounds 1-4 was carried out by spectral data interpretation.