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    Peiminine
    Information
    CAS No. 18059-10-4 Price $100 / 20mg
    Catalog No.CFN99997Purity>=98%
    Molecular Weight429.64Type of CompoundAlkaloids
    FormulaC27H43NO3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Peiminine demonstrates inhibitory effects on IgE-dependent anaphylaxis, it has regulatory potential for allergic inflammatory reactions mediated by HMC-1 cells.
    2. Peiminine can inhibit lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.
    3. Peiminine can repress colorectal carcinoma cell proliferation and cell growth by inducing autophagic cell death.
    Targets: IFN-γ | TGF-β/Smad | ERK | NF-kB | TNF-α | IL Receptor | MAPK
    Peiminine Description
    Source: The bulbus of Fritillaria thunbergii Miq.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3275 mL 11.6377 mL 23.2753 mL 46.5506 mL 58.1883 mL
    5 mM 0.4655 mL 2.3275 mL 4.6551 mL 9.3101 mL 11.6377 mL
    10 mM 0.2328 mL 1.1638 mL 2.3275 mL 4.6551 mL 5.8188 mL
    50 mM 0.0466 mL 0.2328 mL 0.4655 mL 0.931 mL 1.1638 mL
    100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.4655 mL 0.5819 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Peiminine References Information
    Citation [1]

    Mol Med Rep. 2013 Apr;7(4):1103-10.

    Peiminine ameliorates bleomycin-induced acute lung injury in rats.[Pubmed: 23404624]
    The aim of this study was to investigate whether or not Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury. Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with bleomycin-induced lung injury. These protective effects were associated with significant (P<0.05) decreases in the levels of IFN-γ in serum and of TGF-β, CTGF, ERK1/2, NF-κB and FasL in lung tissue. No effects were observed on serum TNF-α or IL-4. In conclusion, Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.
    Citation [2]

    Immunopharmacol Immunotoxicol. 2015;37(4):351-8.

    Antiallergic effects of peiminine through the regulation of inflammatory mediators in HMC-1 cells.[Pubmed: 26121924]
    Peiminine is the main biologically active component derived from Fritillaria ussuriensis. Peiminine was investigated in various pulmonary diseases, but its antiallergic effect and the related mechanism have not been reported yet. The present study aimed to evaluate the effect of Peiminine on mast cell-mediated allergic inflammation in HMC-1 cells. The pro-inflammatory cytokine production was measured using ELISA, reverse transcription-polymerase chain reaction and nuclear factor-kappaB (NF-κB), mitogen-activated protein kinases (MAPKs) pathway activation, as determined by Western blot analysis. Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α) and IL-1beta (IL-1β). It was shown to have inhibitory effects on MAPKs phosphorylation and NF-B expression in human mast cells (HMC)-1 using Western blot. HMC-1 cells were observed for confirmation of histamine release. Passive cutaneous anaphylaxis (PCA) reactions were evaluated using an animal model and Peiminine demonstrated inhibitory effects on IgE-dependent anaphylaxis. These results suggest that Peiminine has regulatory potential for allergic inflammatory reactions mediated by HMC-1 cells.
    Citation [3]

    Biochem Biophys Res Commun. 2015 Jun 19;462(1):38-45.

    The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death.[Pubmed: 25935480 ]
    Autophagy is evolutionarily conservative in eukaryotic cells that engulf cellular long-lived proteins and organelles, and it degrades the contents through fusion with lysosomes, via which the cell acquires recycled building blocks for the synthesis of new molecules. In this study, we revealed that Peiminine induces cell death and enhances autophagic flux in colorectal carcinoma HCT-116 cells. We determined that Peiminine enhances the autophagic flux by repressing the phosphorylation of mTOR through inhibiting upstream signals. Knocking down ATG5 greatly reduced the Peiminine-induced cell death in wild-type HCT-116 cells, while treating Bax/Bak-deficient cells with Peiminine resulted in significant cell death. In summary, our discoveries demonstrated that Peiminine represses colorectal carcinoma cell proliferation and cell growth by inducing autophagic cell death.