ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $25.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
BMC Complement Altern Med.2014, 14:352Acta Agriculturae Scandinavica...2015...Oncotarget.2016, 8(51):88386-88400J Nat Med.2017, 71(2):380-388Nutrients.2018, 10(12):E1998Journal of functional foods...2018...Phys Chem Chem Phys....2018...Phytother Res.2018, 32(12):2551-2559
BMB Rep.2018, 51(5):249-254Analytical methods2019, 11(6)Molecules.2019, 24(11):E2044Molecules.2019, 24(6):E1177Phytother Res.2019, 33(3):676-689Food Sci Nutr.2019, 8(1):246-256Sci Rep.2019, 9:19059Molecules.2020, 25(23):5636.
Biomed Sci Letters.2020, 26:319-326Biosci Rep.2020, 40(8):BSR20201219.Anal Bioanal Chem....2020...Applied Biological Chemistry...2020...Indian J. of Experimental Bio....2020...Clin Exp Pharmacol Physiol....2020...Institut Pasteur Korea...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Ain Shams University (Egypt)Julius Kühn-Institut (Germany)Auburn University (USA)Florida A&M University (USA)
University of Minnesota (USA)Universidade Federal de Goias (... (Brazil)Max Rubner-Institut (MRI) (Germany)University of Sao Paulo (Brazil)
University of British Columbia (Canada)Texas A&M University (USA)Calcutta University (India)
Related Screening Libraries
||Peiminine has potent anti-inflammatory, anti-allergic, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth. Peiminine can inhibit lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.|
||IFN-γ | TGF-β/Smad | ERK | NF-kB | TNF-α | IL Receptor | MAPK | FasL|
|Immunopharmacol Immunotoxicol. 2015;37(4):351-8. |
|Antiallergic effects of peiminine through the regulation of inflammatory mediators in HMC-1 cells.[Pubmed: 26121924]|
|Peiminine is the main biologically active component derived from Fritillaria ussuriensis. Peiminine was investigated in various pulmonary diseases, but its antiallergic effect and the related mechanism have not been reported yet.|
METHODS AND RESULTS:
The present study aimed to evaluate the effect of Peiminine on mast cell-mediated allergic inflammation in HMC-1 cells. The pro-inflammatory cytokine production was measured using ELISA, reverse transcription-polymerase chain reaction and nuclear factor-kappaB (NF-κB), mitogen-activated protein kinases (MAPKs) pathway activation, as determined by Western blot analysis. Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α) and IL-1beta (IL-1β). It was shown to have inhibitory effects on MAPKs phosphorylation and NF-B expression in human mast cells (HMC)-1 using Western blot. HMC-1 cells were observed for confirmation of histamine release. Passive cutaneous anaphylaxis (PCA) reactions were evaluated using an animal model and Peiminine demonstrated inhibitory effects on IgE-dependent anaphylaxis.
These results suggest that Peiminine has regulatory potential for allergic inflammatory reactions mediated by HMC-1 cells.
|Biochem Biophys Res Commun. 2015 Jun 19;462(1):38-45. |
|The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death.[Pubmed: 25935480 ]|
|Autophagy is evolutionarily conservative in eukaryotic cells that engulf cellular long-lived proteins and organelles, and it degrades the contents through fusion with lysosomes, via which the cell acquires recycled building blocks for the synthesis of new molecules. |
METHODS AND RESULTS:
In this study, we revealed that Peiminine induces cell death and enhances autophagic flux in colorectal carcinoma HCT-116 cells. We determined that Peiminine enhances the autophagic flux by repressing the phosphorylation of mTOR through inhibiting upstream signals. Knocking down ATG5 greatly reduced the Peiminine-induced cell death in wild-type HCT-116 cells, while treating Bax/Bak-deficient cells with Peiminine resulted in significant cell death.
In summary, our discoveries demonstrated that Peiminine represses colorectal carcinoma cell proliferation and cell growth by inducing autophagic cell death.
||The bulbus of Fritillaria thunbergii Miq.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Mol Med Rep. 2013 Apr;7(4):1103-10. |
|Peiminine ameliorates bleomycin-induced acute lung injury in rats.[Pubmed: 23404624]|
|The aim of this study was to investigate whether or not Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury. |
METHODS AND RESULTS:
Rats were randomly divided into 4 groups. In 3 groups, intratracheal bleomycin (5 mg/kg) was used to induce acute lung injury, followed by administration of either carboxymethyl cellulose (control group, n=14), dexamethasone (DXS group, n=14) or Peiminine (Peiminine group, n=10). In the fourth group (sham-operated, n=12), normal saline was instilled instead of bleomycin, followed by administration of carboxymethyl cellulose. Drugs were administered intragastrically for 28 days. Lung sections were stained with hematoxylin and eosin (H&E) and Masson's trichrome, to grade the degree of alveolitis and pulmonary fibrosis. The lung index was calculated as the ratio of lung to body weight. Serum levels of interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were obtained using a radioimmunoassay. Immunocytochemical methods were employed to assess the expression of transforming growth factor-β (TGF-β), connective tissue growth factor (CTGF), NF-κB, extracellular signal-related kinase (ERK1/2), Fas and FasL in lung tissue. Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with bleomycin-induced lung injury. These protective effects were associated with significant (P<0.05) decreases in the levels of IFN-γ in serum and of TGF-β, CTGF, ERK1/2, NF-κB and FasL in lung tissue. No effects were observed on serum TNF-α or IL-4.
In conclusion, Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.