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    Periglaucine A
    Periglaucine A
    Information
    CAS No. 1025023-04-4 Price
    Catalog No.CFN99040Purity>=98%
    Molecular Weight373.4 Type of CompoundAlkaloids
    FormulaC20H23NO6Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Periglaucine A inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
    Targets: HBV
    In vitro:
    J Nat Prod. 2008 May;71(5):760-3.
    Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus.[Pubmed: 18396905]

    METHODS AND RESULTS:
    Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of Periglaucine A (1) was confirmed by single-crystal X-ray diffraction.
    CONCLUSIONS:
    Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 microM in C8166 cells (SI = 45.7 and 18.8), respectively.
    Periglaucine A Description
    Source: The aerial parts of Pericampylus glaucus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6781 mL 13.3905 mL 26.7809 mL 53.5619 mL 66.9523 mL
    5 mM 0.5356 mL 2.6781 mL 5.3562 mL 10.7124 mL 13.3905 mL
    10 mM 0.2678 mL 1.339 mL 2.6781 mL 5.3562 mL 6.6952 mL
    50 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.0712 mL 1.339 mL
    100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.5356 mL 0.6695 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.