Science | Nature | Cell | View More
Natural Products
Polyphyllin II
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Polyphyllin II
Price:
CAS No.: 76296-72-5
Catalog No.: CFN99953
Molecular Formula: C44H70O16
Molecular Weight: 855.02 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: White cryst.
Source: The rhizomes of Paris yunnanensis Franch.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Charles University in Prague (Czech Republic)
  • University of Ioannina (Greece)
  • Copenhagen University (Denmark)
  • University of Wuerzburg (Germany)
  • Monash University (Australia)
  • University of Bonn (Germany)
  • China Medical University (Taiwan)
  • Shanghai Institute of Biochemis... (China)
  • National Chung Hsing University (Taiwan)
  • University of Leipzig (Germany)
  • Kyung Hee University (Korea)
  • More...
Package
Featured Products
Corilagin

Catalog No: CFN90176
CAS No: 23094-69-1
Price: $50/20mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Chebulic acid

Catalog No: CFN92293
CAS No: 23725-05-5
Price: $368/10mg
Afzelin

Catalog No: CFN98757
CAS No: 482-39-3
Price: $288/20mg
Magnolignan A

Catalog No: CFN96188
CAS No: 93673-81-5
Price: $318/10mg
Cryptotanshinone

Catalog No: CFN98478
CAS No: 35825-57-1
Price: $30/20mg
Polygalacin D

Catalog No: CFN93351
CAS No: 66663-91-0
Price: $/mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Myrcene

Catalog No: CFN70046
CAS No: 123-35-3
Price: $30/20mg
Licoricidin

Catalog No: CFN96389
CAS No: 30508-27-1
Price: $388/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Polyphyllin II has hemolytic effect, the hemolytic mechanism in vitro may be related to the increase in intracellular osmotic pressure and rupture of erythrocytes by changing the anion channel transport activity, with glucose transporter 1 (GLUT1) as the major competitive interaction site.
Targets: GLUT
In vitro:
Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(18):3623-9.
Study on hemolytic mechanism of polyphyllin II.[Pubmed: 26983211]
To study the hemolytic effect of Polyphyllin II (PP II) mediated by anion channel protein and glucose transporter 1 (GLUT1), in order to initially reveal its hemolytic mechanism in vitro.
METHODS AND RESULTS:
In the experiment, the spectrophotometric method was adopted to detect the hemolysis of PP II in vitro and the effect of anion channel-related solution and blocker, glucose channel-related inhibitor and multi-target drugs dehydroepiandrosterone (DHEA) and diazepam on the hemolysis of PP II. The scanning electron microscope and transmission electron microscope were used to observe the effect of PP II on erythrocyte (RBC) morphology. The results showed that PP II -processed blood cells were severely deformed into spherocytes, acanthocyturia and vesicae. According to the results of the PP II hemolysis experiment in vitro, the anion hypertonic solution LiCl, NaHCO3, Na2SO4 and PBS significantly inhibited the hemolysis induced by PP II (P < 0.05), while blockers NPPB and DIDS remarkably promoted it (P < 0.01). Hyperosmotic sodium chloride, fructose and glucose at specific concentrations notably antagonized the hemolysis induced by PP II (P < 0.05). The glucose channel inhibitor Cytochalasin B and verapamil remarkably antagonized the hemolysis induced by PP II (P < 0.01). The hemolysis induced by PP II could also be antagonized by 1 gmol x L(1) diazepam and 100 μmol x L(-1) DHEA pretreated for 1 min (P < 0.01).
CONCLUSIONS:
In conclusion, the hemolytic mechanism of PP II in vitro may be related to the increase in intracellular osmotic pressure and rupture of erythrocytes by changing the anion channel transport activity, with GLUT1 as the major competitive interaction site.
Polyphyllin II Description
Source: The rhizomes of Paris yunnanensis Franch.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
(3beta,22alpha)-26-(beta-glucopyra...

Catalog No: CFN95321
CAS No: 107783-53-9
Price: $318/20mg
Lariciresinol 4'-O-glucoside

Catalog No: CFN95400
CAS No: 107110-16-7
Price: $318/5mg
Physalin O

Catalog No: CFN95097
CAS No: 120849-18-5
Price: $413/5mg
12beta-Acetoxy-7beta-hydroxy-3,11,...

Catalog No: CFN95515
CAS No: N/A
Price: $318/5mg
4,4-di(4-hydroxy-3-methoxyphenly)-...

Catalog No: CFN95200
CAS No: 913643-31-9
Price: $368/5mg
10-O-trans-p-coumaroylscandoside

Catalog No: CFN95391
CAS No: 870785-25-4
Price: $318/10mg
Bayin

Catalog No: CFN95539
CAS No: 3681-96-7
Price: $318/5mg
(R)-Mucronulatol

Catalog No: CFN95492
CAS No: 57128-11-7
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1696 mL 5.8478 mL 11.6956 mL 23.3913 mL 29.2391 mL
5 mM 0.2339 mL 1.1696 mL 2.3391 mL 4.6783 mL 5.8478 mL
10 mM 0.117 mL 0.5848 mL 1.1696 mL 2.3391 mL 2.9239 mL
50 mM 0.0234 mL 0.117 mL 0.2339 mL 0.4678 mL 0.5848 mL
100 mM 0.0117 mL 0.0585 mL 0.117 mL 0.2339 mL 0.2924 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Biomed Chromatogr. 2013 Mar;27(3):343-8.
Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS-MS.[Pubmed: 22903625]

METHODS AND RESULTS:
For the first time, a rapid and specific LC-MS-MS method has been developed for the analysis of polyphyllin I, Polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma. The method was applied to study the pharmacokinetics of Rhizoma Paridis extracts containing polyphyllin I, Polyphyllin II, polyphyllin VI and polyphyllin VII. The analysis was carried out on an Agilent Zorbax XDB-C(18) reversed-phase column (100 × 2.1 mm, 1.8 μm) by isocratic elution with acetonitrile and water (50:50, v/v). The flow rate was 0.25 mL/min. All analytes including internal standards were monitored by selected reaction monitoring with an electrospray ionization source. Linear responses were obtained for polyphyllin I, Polyphyllin II, polyphyllin VI and polyphyllin VII ranging from 10 to 5000 ng/mL. The intra-and inter-day precisions (RSDs) were less than 6.66 and 9.15%. The extraction recovery ranged from 95.53 to 104.21% with RSD less than 8.69%. Stability studies showed that polyphyllin I, Polyphyllin II, polyphyllin VI and polyphyllin VII were stable in preparation and analytical process.
CONCLUSIONS:
The validated method was successfully used to determine the concentration-time profiles of polyphyllin I, Polyphyllin II, polyphyllin VI and polyphyllin VII.
Corilagin

Catalog No: CFN90176
CAS No: 23094-69-1
Price: $50/20mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Chebulic acid

Catalog No: CFN92293
CAS No: 23725-05-5
Price: $368/10mg
Afzelin

Catalog No: CFN98757
CAS No: 482-39-3
Price: $288/20mg
Magnolignan A

Catalog No: CFN96188
CAS No: 93673-81-5
Price: $318/10mg
Cryptotanshinone

Catalog No: CFN98478
CAS No: 35825-57-1
Price: $30/20mg
Polygalacin D

Catalog No: CFN93351
CAS No: 66663-91-0
Price: $/mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Myrcene

Catalog No: CFN70046
CAS No: 123-35-3
Price: $30/20mg
Licoricidin

Catalog No: CFN96389
CAS No: 30508-27-1
Price: $388/5mg
Tags: buy Polyphyllin II | Polyphyllin II supplier | purchase Polyphyllin II | Polyphyllin II cost | Polyphyllin II manufacturer | order Polyphyllin II | Polyphyllin II distributor