• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Pseudolycorine
    Information
    CAS No. 29429-03-6 Price
    Catalog No.CFN98548Purity>=98%
    Molecular Weight289.33Type of CompoundAlkaloids
    FormulaC16H19NO4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Shanghai Institute of Organic Ch... (China)
  • Universidad de Ciencias y Artes ... (Mexico)
  • Sanford Burnham Prebys Medical D... (USA)
  • University of Liège (Belgium)
  • University of Indonesia (Indonesia)
  • University of Vienna (Austria)
  • Institute of Chinese Materia Med... (China)
  • Chungnam National University (Korea)
  • Seoul National University (Korea)
  • University of British Columbia (Canada)
  • Chulalongkorn University (Thailand)
  • More...
  • Package
    Featured Products
    Kaempferol-3-O-galactoside

    Catalog No: CFN92079
    CAS No: 23627-87-4
    Price: $398/5mg
    Salvigenin

    Catalog No: CFN99883
    CAS No: 19103-54-9
    Price: $338/10mg
    2,4'-Dihydroxybenzophenone

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $510/5mg
    Oroselol

    Catalog No: CFN95001
    CAS No: 1891-25-4
    Price: $358/5mg
    Biological Activity
    Description: 1. Pseudolycorine can halt HeLa cell growth at 10-1 mM or lower concentrations, it at its growth inhibitory concentrations blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo.
    2. Pseudolycorine exhibits cytotoxic profiles against cancer cell lines.
    3. Pseudolycorine and haemanthamine show good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66 uM or lower.
    4. Pseudolycorine, primarily studied as a new antiviral agent , it also shows remarkable antileukemic activity.
    Targets: Antifection | DNA/RNA Synthesis
    Pseudolycorine Description
    Source: The bulbus of Lycoris radiata (L. Herit.) Herb
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Picrasidine I

    Catalog No: CFN99019
    CAS No: 100234-59-1
    Price: $368/5mg
    3-O-Caffeoylquinic acid methyl est...

    Catalog No: CFN92573
    CAS No: 123483-19-2
    Price: $198/10mg
    Alloisoimperatorin

    Catalog No: CFN95012
    CAS No: 35214-83-6
    Price: $338/5mg
    Irigenin

    Catalog No: CFN93276
    CAS No: 548-76-5
    Price: $238/20mg
    Militarine

    Catalog No: CFN90409
    CAS No: 58139-23-4
    Price: $188/10mg
    Isochlorogenic acid B

    Catalog No: CFN99119
    CAS No: 14534-61-3
    Price: $108/20mg
    6-Hydroxywogonin

    Catalog No: CFN95009
    CAS No: 76844-70-7
    Price: $368/5mg
    Ganoderic acid C2

    Catalog No: CFN92054
    CAS No: 103773-62-2
    Price: $660/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4563 mL 17.2813 mL 34.5626 mL 69.1252 mL 86.4065 mL
    5 mM 0.6913 mL 3.4563 mL 6.9125 mL 13.825 mL 17.2813 mL
    10 mM 0.3456 mL 1.7281 mL 3.4563 mL 6.9125 mL 8.6407 mL
    50 mM 0.0691 mL 0.3456 mL 0.6913 mL 1.3825 mL 1.7281 mL
    100 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.6913 mL 0.8641 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Pseudolycorine References Information
    Citation [1]

    J Nat Prod. 2010 Jul 23;73(7):1223-7.

    Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.[Pubmed: 20550100]
    Fifteen Amaryllidaceae alkaloids (1-15) were evaluated for their antiproliferative activities against six distinct cancer cell lines. Several of these natural products were found to have low micromolar antiproliferative potencies. The log P values of these compounds did not influence their observed activity. When active, the compounds displayed cytostatic, not cytotoxic activity, with the exception of Pseudolycorine (3), which exhibited cytotoxic profiles. The active compounds showed similar efficacies toward cancer cells irrespective of whether the cell lines were responsive or resistant to proapoptotic stimuli. Altogether, the data from the present study revealed that lycorine (1), amarbellisine (6), haemanthamine (14), and haemanthidine (15) are potentially useful chemical scaffolds to generate further compounds to combat cancers associated with poor prognoses, especially those naturally resistant to apoptosis, such as glioblastoma, melanoma, non-small-cell lung, and metastatic cancers.
    Citation [2]

    Phytochem. Lett., 2010, 3(3):161-3.

    In vitro antiprotozoal activity of alkaloids from Phaedranassa dubia (Amaryllidaceae).[Reference: WebLink]
    The bulbs of Phaedranassa dubia (Amaryllidaceae) were found to contain the novel compound phaedranamine, together with seven known alkaloids. The structure and stereochemistry of the alkaloids were determined by physical and spectroscopic methods. An in vitro screening against four different parasitic protozoa was carried out using the isolated compounds. The alkaloids ungeremine, Pseudolycorine and haemanthamine showed good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66 μM or lower.
    Citation [3]

    Proc. Soc. Exp. Biol. Med., 1971 ,136(4): 1168-73.

    Therapeutic Activity of Narcissus Alkaloid on Rauscher Leukemia and Comparison with Standard Drugs[Reference: WebLink]
    An alkaloid (2-X), tentatively identified as Pseudolycorine, has been isolated from Narcissus tazetta L. This alkaloid, primarily studied as a new antiviral agent derived from the screening of medicinal plants of the Pacific area, has been shown to exert a superior prolongation effect on the life span of established Rauscher leukemic mice having palpable splenomegaly, in comparison with standard antileukemic drugs. It was found that the alkaloid suppressed the development of splenomegaly and the increase in number of nucleated blood cells, and dropped the virus titer in plasma without apparent toxicity. A second alkaloidal complex, called residual alkaloid, also showed remarkable antileukemic activity.
    Citation [4]

    Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.

    Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed: 944052]
    The effects of eighteen compounds obtained from bulbs of the Amaryllidaceae family were tested on (a) animal cell growth, (b) DNA, RNA and protein synthesis by intact cells and (c) protein synthesis in cell-free systems. Dihydrolycorine, haemanthamine, lycorine, narciclasine, pretazettine and Pseudolycorine halted HeLa cell growth at 10(-1) mM or lower concentrations. These compounds at their growth inhibitory concentrations block protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Endomyocarditis virus RNA-directed cell-free polypeptide synthesis by an ascites S-30 extract and acetyl-[14C]leucyl-puromycin formation by ascites ribosomes are also inhibited by the six compounds indicated above. It is therefore concluded that they halt protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step.