Pterisolic acid B | CAS:1401419-86-0 | Manufacturer ChemFaces

Pterisolic acid B

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Description:

Pterisolic acid B (J19) is an effective Nrf2 activator. we have also identified a more potent natural product analogue J19-1, J19-1 shows significant cytoprotective effect against cisplatin-induced cytotoxicity in HKC cells.

Targets:

Nrf2

In vitro:

Sci. Rep.-UK, 2016, 6,19231.

Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain[Pubmed: PMC4725373]

The use of chemoprotective agents to minimize the side effects of the chemotherapy, primarily via activation of the Nrf2 pathway, is an emerging research field, which has attracted broad attention from both academia and pharmaceutical industry.
METHODS AND RESULTS:
Through high-throughput chemical screens we have disclosed that Pterisolic acid B (J19), a naturally occuring diterpenoid, is an effective Nrf2 activator. We have also identified a more potent natural product analogue J19-1 by semisynthesis and the subsequent biochemical evaluations revealed that J19-1 activates the Nrf2 pathway by covalently modifying Cys171 of keap1, which inhibits Nrf2 degradation mediated by Keap1-Cul3 complexes.
CONCLUSIONS:
Ultimately, we have demonstrated that J19-1 shows significant cytoprotective effect against cisplatin-induced cytotoxicity in HKC cells.

Pterisolic acid B Description

Source:	The herbs of Pteris semipinnata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Pterisolic acid B
Price:
CAS No.:	1401419-86-0
Catalog No.:	CFN97976
Molecular Formula:	C₂₀H₂₆O₄
Molecular Weight:	330.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Pteris semipinnata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytoprotective Compound Library Activators Compound Library Diterpenoids Compound Library Nrf2 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0266 mL	15.1332 mL	30.2663 mL	60.5327 mL	75.6659 mL
5 mM	0.6053 mL	3.0266 mL	6.0533 mL	12.1065 mL	15.1332 mL
10 mM	0.3027 mL	1.5133 mL	3.0266 mL	6.0533 mL	7.5666 mL
50 mM	0.0605 mL	0.3027 mL	0.6053 mL	1.2107 mL	1.5133 mL
100 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.6053 mL	0.7567 mL

CFN89107	ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide	59885-89-1	346.42	C₂₀H₂₆O₅
CFN97975	Pterisolic acid A	1401419-85-9	346.4	C₂₀H₂₆O₅
CFN97976	Pterisolic acid B	1401419-86-0	330.4	C₂₀H₂₆O₄
CFN89078	ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	57719-81-0	332.44	C₂₀H₂₈O₄
CFN89216	Paniculoside III	60129-65-9	494.58	C₂₆H₃₈O₉
CFN96331	ent-16-Kaurene-3beta,15beta,18-triol	921211-29-2	320.5	C₂₀H₃₂O₃
CFN97780	Grandifloric acid	22338-69-8	318.46	C₂₀H₃₀O₃
CFN97131	Deacetylxylopic acid	6619-95-0	318.5	C₂₀H₃₀O₃
CFN98977	11,15-Dihydroxy-16-kauren-19-oic acid	57719-76-3	334.5	C₂₀H₃₀O₄
CFN97261	ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid	77658-39-0	332.4	C₂₀H₂₈O₄