ChemFaces is a professional high-purity natural products manufacturer.
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More articles cited ChemFaces products.
LWT - Food Science and Technology2017 Jan.J. of Pha. and Biomed. Analysis25 Jan. 2016British Jou. Med. & Med. Research2014 Jan 1Korean J. of Horticultural Sci. & Tech. No.2, 2017.2Mediators Inflamm.2016:7216912.
Plant Cell Physiol.2018 Jan 1;Scientific Reports2015 August 26 Molecules. 2017 Feb 8;Acta Physiologiae PlantarumJanuary 2016, 38:7Free Radic Biol Med.2017 Nov;
Int J Mol Sci.2015 Aug 7;16(8):18396-411.?J. Soc. Cosmet. Sci. KoreaJune 2016Food Analytical Methods07 April 2017Phytomedicine15 Dec. 2015,1262–1268
Our products had been exported to the following research institutions and universities, And still growing.
Donald Danforth Plant Science Ce... (USA)University of Hertfordshire (United Kingdom)Heinrich-Heine-University Düsse... (Germany)Institute of Tropical Disease Un... (Indonesia)
Complutense University of Madrid (Spain)University of Toulouse (France)Ateneo de Manila University (Philippines)Texas A&M University (USA)
Universite Libre de Bruxelles (Belgium)Cancer Research Initatives Found... (Malaysia)University of Brasilia (Brazil)
|| Quercetin 3-O-glucoside-7-O-rhamnoside at 30 mg/kg i.p. can decrease the ambulatory locomotor activity and increase the sodium thiopental-induced time of loss of the righting reflex suggesting a clear depressant action. |
|Phytother Res. 2009 Oct;23(10):1453-7. |
|Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts.[Pubmed: 19288528]|
|Pharmacological assay guided purification of an ethanol extract of Tilia petiolaris DC. inflorescences resulted in the isolation and identification of isoquercitrin (ISO), Quercetin 3-O-glucoside-7-O-rhamnoside (QUE) and kaempferol 3-O-glucoside-7-O-rhamnoside (KAE).
METHODS AND RESULTS:
The behavioral actions of these glycosylated flavonoids were examined in the hole board, locomotor activity and thiopental-induced loss of righting reflex tests in mice. Quercetin 3-O-glucoside-7-O-rhamnoside (10 and 30 mg/kg) and KAE (30 mg/kg), intraperitoneally (i.p.) administered to mice, reduced all the parameters measured in the hole board test, but ISO (30 mg/kg) only reduced the number of rearings. Meanwhile Quercetin 3-O-glucoside-7-O-rhamnoside at 30 mg/kg i.p. also decreased the ambulatory locomotor activity and increased the sodium thiopental-induced time of loss of the righting reflex suggesting a clear depressant action.
The above results demonstrate the occurrence of neuroactive flavonoid glycosides in Tilia.
Quercetin 3-O-glucoside-7-O-rhamnoside Description
||The herbs of Hippophae rhamnoides Linn.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Appl Microbiol Biotechnol. 2013 Jun;97(12):5275-82. |
|Regioselective synthesis of flavonoid bisglycosides using Escherichia coli harboring two glycosyltransferases.[Pubmed: 23549747 ]|
|Regioselective glycosylation of flavonoids cannot be easily achieved due to the presence of several hydroxyl groups in flavonoids.
METHODS AND RESULTS:
This hurdle could be overcome by employing uridine diphosphate-dependent glycosyltransferases (UGTs), which use nucleotide sugars as sugar donors and diverse compounds including flavonoids as sugar acceptors. Quercetin rhamnosides contain antiviral activity. Two quercetin diglycosides, Quercetin 3-O-glucoside-7-O-rhamnoside and quercetin 3,7-O-bisrhamnoside, were synthesized using Escherichia coli expressing two UGTs. For the synthesis of Quercetin 3-O-glucoside-7-O-rhamnoside, AtUGT78D2, which transfers glucose from UDP-glucose to the 3-hydroxyl group of quercetin, and AtUGT89C1, which transfers rhamnose from UDP-rhamnose to the 7-hydroxyl group of quercetin 3-O-glucoside, were transformed into E. coli. Using this approach, 67 mg/L of Quercetin 3-O-glucoside-7-O-rhamnoside was synthesized. For the synthesis of quercetin 3,7-O-bisrhamnoside, AtUGT78D1, which transfers rhamnose to the 3-hydroxy group of quercetin, and AtUGT89C1 were used.
The RHM2 gene from Arabidopsis thaliana was coexpressed to supply the sugar donor, UDP-rhamnose. E. coli expressing AtUGT78D1, AtUGT89C1, and RHM2 was used to obtain 67.4 mg/L of quercetin 3,7-O-bisrhamnoside.