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    Rubiadin
    Information
    CAS No. 117-02-2 Price $168 / 10mg
    Catalog No.CFN99270Purity>=98%
    Molecular Weight254.2 Type of CompoundAnthraquinones
    FormulaC15H10O4Physical DescriptionYellow powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Toronto (Canada)
  • Universidade Católica Portuguesa (Portugal)
  • Michigan State University (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • Kazusa DNA Research Institute (Japan)
  • University of Eastern Finland (Finland)
  • University of Padjajaran (Indonesia)
  • Guangzhou Institutes of Biomedic... (China)
  • Monash University Malaysia (Malaysia)
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  • Istanbul University (Turkey)
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    Biological Activity
    Description: Rubiadin has hepatoprotective, antioxidant, and antitumor promoting effects. Rubiadin can decrease bone loss through the inhibition of osteoclast formation,differentiation and bone resorption.
    Targets: Caspase | PARP
    In vitro:
    Photodiagnosis Photodyn Ther. 2014 Jun;11(2):182-92.
    Photochemotherapy using natural anthraquinones: Rubiadin and Soranjidiol sensitize human cancer cell to die by apoptosis.[Pubmed: 24561303]
    Over the past decade the science has studied synthetic photosensitizers used in photodynamic therapy (PDT) or photochemotherapy as anticancer candidates. In this context, compounds extracted from vegetable species present interesting potential in the cancer field.
    METHODS AND RESULTS:
    In our laboratory, we studied Heterophyllaea pustulata a phototoxic shrub that habit the northwest of Argentina. From this vegetal, by in vitro germination, we obtained Rubiadin and Soranjidiol, two anthraquinones that exhibited significant photocytotoxicity on human cancer cells. In addition, the fraction obtained from callus cultures allowed us to get a satisfactory content of these compounds compared to those found from the original plant. Under PDT regimen, we found that cell destruction resulted in a dose-dependent manner and occasioned apoptosis on photosensitized cells. Biochemical analysis revealed the involvement of caspase-3, PARP cleavage and DNA fragmentation in Rubiadin induced apoptosis. Moreover, Soranjidiol-PDT led to μ-calpain-induced apoptosis involving caspases-3-independent DNA fragmentation. We also showed that both anthraquinones are cytoplasmatically distributed and out of nucleus. In addition, we demonstrated a synergic cytotoxic effect when we combined them.
    CONCLUSIONS:
    Our data demonstrated that Rubiadin and Soranjidiol could be further considered as natural photocytotoxic compounds against cancer cells and callus cultures are a plausible source of these anthraquinonic compounds.
    Med Chem. 2011 Nov;7(6):639-44.
    Free radical scanvenging and antioxidant effects of some anthraquinone derivatives.[Pubmed: 22313303]

    METHODS AND RESULTS:
    In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, Rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2'-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 µg/ml. Results of β-carotene/linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5% and 68.6 ± 2.5%, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+-ferrozine complex.
    CONCLUSIONS:
    These results are promising for further studies of the biological and pathological effects of these natural products.
    Asia-Pacific Journal of Molecular Biology and Biotechnology, 2003, 11(1):3-7.
    Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica[Reference: WebLink]
    Six anthraquinones (nordamnacanthal, alizarin-1-methyl ether, Rubiadin, soranjidiol, lucidin-ω-methyl ether and morindone) isolated from the cell suspension culture of Morinda elliptica were assayed for antitumor promoting and antioxidant activities.
    METHODS AND RESULTS:
    All compounds exhibited strong antitumor promoting activity at the concentration of 2.0 μg/ml when assayed using the inhibition test of Epstein Barr Virus (EBV) activation on Raji cells. At the concentration of 0.4 μg/ml, only nordamnacanthal exhibited strong antitumor promoting activity with the inhibition rate and the cell viability of 75.0% and 75.8%, respectively, which was stronger than the reference compounds genistein and quercetin. In antioxidant assay using ferric thiocyanate (FTC) method, nordamnacanthal and morindone showed stronger antioxidant activity than α-tocopherol. However when the compounds were assayed for scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, only morindone was considered to be active as free radical scavenger with fifty percent inhibition concentration (IC50) of 40.6 μg/ml.
    Rubiadin Description
    Source: The roots of Rubia cordifolia.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

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    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
    5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
    10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
    50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
    100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Pharmaceutical Journal of Chinese Peoples Liberation Army, 2009, 25(6):505-9.
    Effects of Rubiadin from Morinda officinalis on Osteoclastic Bone Resorption[Reference: WebLink]
    To investigate the cellular mechanism of Rubiadin inhibitory effects on bone resorption.
    METHODS AND RESULTS:
    Multinucleated osteoclasts were induced by 1,25-dihydroxyvitamine D 3 and dexamethasone from bone marrow cells and cocultured with primary osteoblastic cells.The activity of TRAP was measured by p-nitrophenyl sodium phosphate assay.The bone resorption pit area on the bone slices formed by osteoclast was measured by computer image processing.The cathepsin K was measured by fluorescence microplate reader. At the concentration of 0.1,1 and 10μmol · L-1,Rubiadin dose-dependently suppressed the formation of TRAP-positive multinucleated cells,the TRAP activity and the osteoclastic bone resorption.
    CONCLUSIONS:
    Rubiadin can decrease bone loss through the inhibition of osteoclast formation,differentiation and bone resorption.