S-Adenosyl-L-methionine tosylate | CAS:71914-80-2

S-Adenosyl-L-methionine tosylate

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Description:

S-adenosyl-L-methionine tosylate has a beneficial effect on the outcome of ischemic injury by reducing the blood-brain barrier (BBB) breakdown and neuronal death.

In vivo:

Brain Res Mol Brain Res. 1997 Feb;44(1):134-8.

Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils.[Pubmed: 9030707]

We have studied the beneficial effects of S-Adenosyl-L-methionine tosylate on blood-brain barrier (BBB) breakdown and neuronal survival after transient cerebral ischemia in gerbils.
METHODS AND RESULTS:
BBB breakdown experiments were performed in pentobarbital anesthetized gerbils subjected to 10 min of bilateral carotid artery occlusion and 6 h of reperfusion. For BBB breakdown measurements, S-adenosyl-L-methionine (120 mg/kg, i.p.) was administered to gerbils just after occlusion and thereafter every hour up to 5 h. Fluorometric measurements quantified the blood-brain permeability tracer, Evans blue (EB). S-adenosyl-L-methionine treatment significantly reduced the BBB breakdown as indicated by reduced levels of EB fluorescence. Neuronal count experiments were conducted in gerbils subjected to transient ischemia and 7 days of reperfusion. For neuronal count experiments S-adenosyl-L-methionine (15-120 mg/kg) was administered at 6 and 12 h after reperfusion, and twice each day thereafter for 7 days. S-adenosyl-L-methionine dose dependently protected the hippocampal CA1 neurons assessed by histopathological methods.
CONCLUSIONS:
S-adenosyl-L-methionine has a beneficial effect on the outcome of ischemic injury by reducing the BBB breakdown and neuronal death.

S-Adenosyl-L-methionine tosylate Description

Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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CAS No.	71914-80-2	Price
Catalog No.	CFN90074	Purity	>=98%
Molecular Weight	570.6	Type of Compound	Alkaloids
Formula	C₂₂H₃₀N₆O₈S₂	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-cerebral ischemia Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7525 mL	8.7627 mL	17.5254 mL	35.0508 mL	43.8135 mL
5 mM	0.3505 mL	1.7525 mL	3.5051 mL	7.0102 mL	8.7627 mL
10 mM	0.1753 mL	0.8763 mL	1.7525 mL	3.5051 mL	4.3814 mL
50 mM	0.0351 mL	0.1753 mL	0.3505 mL	0.701 mL	0.8763 mL
100 mM	0.0175 mL	0.0876 mL	0.1753 mL	0.3505 mL	0.4381 mL

CFN93249	Inosine	58-63-9	268.2	C₁₀H₁₂N₄O₅
CFN99004	Caffeine	58-08-2	194.2	C₈H₁₀N₄O₂
CFN89099	1,3,9-Trimethyluric acid	7464-93-9	210.19	C₈H₁₀N₄O₃
CFN80067	5'-IMPdisodium salt	4691-65-0	392.17	C₁₀H₁₁N₄Na₂O₈P
CFN99524	Crotonoside	1818-71-9	283.24	C₁₀H₁₃N₅O₅
CFN96592	Hypoxanthine	68-94-0	136.11	C₅H₄N₄O
CFN95087	3-Methylxanthine	1076-22-8	166.1	C₆H₆N₄O₂
CFN99737	Theobromine	83-67-0	180.16	C₇H₈N₄O₂
CFN99768	Theophylline	58-55-9	180.16	C₇H₈N₄O₂
CFN89041	Adenine	73-24-5	135.13	C₅H₅N₅