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    Sibiricose A5
    Sibiricose A5
    Information
    CAS No. 107912-97-0 Price $138 / 20mg
    Catalog No.CFN90645Purity>=98%
    Molecular Weight518.5Type of CompoundPhenylpropanoids
    FormulaC22H30O14Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Sibiricose A5 Description
    Source: The roots of Polygala tenuifolia
    Biological Activity or Inhibitors: 1. Sibiricose A5 displays antidepressant-like action, it may prevent or relieve depression.
    2. Sibiricose A5 is a lactate dehydrogenase inhibitor.
    3. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.
    4. Sibiricose A5 shows potent antioxidant activity.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9286 mL 9.6432 mL 19.2864 mL 38.5728 mL 48.216 mL
    5 mM 0.3857 mL 1.9286 mL 3.8573 mL 7.7146 mL 9.6432 mL
    10 mM 0.1929 mL 0.9643 mL 1.9286 mL 3.8573 mL 4.8216 mL
    50 mM 0.0386 mL 0.1929 mL 0.3857 mL 0.7715 mL 0.9643 mL
    100 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.3857 mL 0.4822 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Sibiricose A5 References Information
    Citation [1]

    Molecules. 2011 Jun 29;16(7):5507-13.

    Absorbable phenylpropenoyl sucroses from Polygala tenuifolia.[Pubmed: 21716172]
    Three phenylpropenoyl sucroses--Sibiricose A5, A6 and 3',6-disinapoyl sucrose--were isolated from the 30% EtOH extract of Polygala tenuifolia, which displayed antidepressant-like action. HPLC analysis indicated that the three phenylpropenoyl sucroses could be absorbed into serum. From the serum pharmacochemistry point of view, these three phenylpropenoyl sucroses might prevent or relieve depression.
    Citation [2]

    Zhongguo Zhong Yao Za Zhi. 2004 Aug;29(8):751-3.

    Studies on the chemical constituents in root bark of Polygala tenuifolia (II)[Pubmed: 15506285]
    OBJECTIVE: To study the chemical constituents of Polygala tenuifolia. METHOD: Isolations were performed on various chromatography columns and structure elucidations were aided by spectral data and chemical property analyses. RESULT: Four compounds were isolated from the roots of P. tenuifolia. Their structures were identified as Sibiricose A5 (1), sibiricose A6 (2), tenuifoliside A (3) and 3',6-disinapoyl sucrose (4). CONCLUSION: Compounds 1 and 2 were isolated from this plant for the first time.
    Citation [3]

    J Sep Sci. 2017 Mar;40(6):1385-1395.

    Bioactivity screening, extraction, and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd. based on a hyphenated strategy.[Pubmed: 28134488 ]
    Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this study, ultrafiltration liquid chromatography coupled with mass spectrometry was used for the screening and identification of lactate dehydrogenase inhibitors from Polygala tenuifolia. Furthermore, five lactate dehydrogenase inhibitors, Sibiricose A5, 3,6'-di-O-sinapoyl-sucrose, glomeratose A, tenuifoliside B, and tenuifoliside C, were selected as target lactate dehydrogenase inhibitors.
    Citation [4]

    Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(11):1278-80.

    Study on antidepressant components of sucrose ester from Polygala tenuifolia.[Pubmed: 18831206]
    To investigate the antidepressant components of Polygala tenuifolia. METHOD: The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities. RESULT: Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), Sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed. CONCLUSION: Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.
    Citation [5]

    Talanta. 2015 Nov 1;144:830-5.

    Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC-ESI-Q-TOF-MS/MS.[Pubmed: 26452897 ]
    The method is based on the hypothesis that upon reaction of antioxidants with 1,1-diphenyl-2-picrylhydrazyl (DPPH), the peak areas of compounds with potential antioxidant activities in the HPLC chromatogram will be significantly reduced in comparison to the untreated sample. The identity confirmation was achieved by Q-TOF-MS/MS technique. With this method, eight components were proposed possessing potent antioxidant activity. They were identified as Sibiricose A5, sibiricose A6, sucrose monoester, polygalaxanthone III, tenuifoliside B, 3',6-disinapoylsucrose (DISS), sucrose diester, tenuifoliside C, respectively. DISS was proposed to be the most potent one.