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    Soyasaponin Ba
    Information
    CAS No. 114590-20-4 Price $418 / 20mg
    Catalog No.CFN90722Purity>=98%
    Molecular Weight959.1Type of CompoundTriterpenoids
    FormulaC48H78O19Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $258.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Description: Soyasaponins(Aa, Ab, Af, Ba, Bb, and Bb') together with their derivatives may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.
    Targets: cAMP
    In vivo:
    J.Agr.Food Chem., 2014, 62(9):2062-8.
    Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.[Pubmed: 24450802 ]
    Soy (Glycine max, family Leguminosae), which contains isoflavones and saponins as main constituents, is known to exhibit memory-enhancing effects.
    METHODS AND RESULTS:
    Therefore, to investigate the role of soyasaponins in memory impairments, we isolated soyasaponin Ab (SA) and soyasaponin Bb (SB) from soybean and measured their protective effects against scopolamine-induced memory impairment in mice. SA and SB significantly prevented scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Compared to SA, SB rescued memory impairment more potently. Treatment with SB (10 mg/kg, p.o.) protected memory impairment in passive avoidance and Y-maze tasks to 97% (F = 68.10, P < 0.05) and 78% (F = 35.57, P < 0.05) of untreated normal control level, respectively. SA and SB (10 mg/kg) also rescued scopolamine-induced memory impairment in Morris water maze task (F = 14.51, P < 0.05). In addition, soyasaponins preserved brain-derived neurotrophic factor (BNDF) expression (F = 33.69, P < 0.05) and cAMP response element-binding (CREB) protein phosphorylation (F = 91.62, P < 0.05) in the hippocampus of scopolamine-treated mice. However, SA and SB did not inhibit acetylcholinesterase in vitro and ex vivo.
    CONCLUSIONS:
    On the basis of these findings, we suggest that soybean, particularly soyasaponins, may protect memory impairment by increasing BDNF expression and CREB phosphorylation.
    Soyasaponin Ba Description
    Source: The seeds of Glycine max
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0426 mL 5.2132 mL 10.4264 mL 20.8529 mL 26.0661 mL
    5 mM 0.2085 mL 1.0426 mL 2.0853 mL 4.1706 mL 5.2132 mL
    10 mM 0.1043 mL 0.5213 mL 1.0426 mL 2.0853 mL 2.6066 mL
    50 mM 0.0209 mL 0.1043 mL 0.2085 mL 0.4171 mL 0.5213 mL
    100 mM 0.0104 mL 0.0521 mL 0.1043 mL 0.2085 mL 0.2607 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    《Journal of Medical Science Yanbian University》 2002-04
    Determination of soyasaponin Ba and Bb in Soybean Hypocotyl by high performance liquid chromatography[Reference: WebLink]
    To establish a method for determination of Soyasaponin Ba and Bb.
    METHODS AND RESULTS:
    Soyasaponin Ba and Bb were detected by a reversed-phase liquid chromatographic method. The method was proved to be linear in the range of 2 24~11 20μg and 2 35~11 80μg, and the intra-day coefficients of variation of assay for Soyasaponin Ba and Bb were 3 15% and 3 98%, respectively.
    CONCLUSIONS:
    The method is accurate and reproducible, suitable for determination of Soyasaponin Ba and Bb.