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    CAS No. 34209-69-3 Price
    Catalog No.CFN90598Purity>=98%
    Molecular Weight388.15Type of CompoundLignans
    FormulaC21H24O7Physical DescriptionCryst.
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Korea Food Research Institute(KF... (Korea)
  • University of Dicle (Turkey)
  • Chang Gung University (Taiwan)
  • Universidade Católica Portuguesa (Portugal)
  • The University of Newcastle (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Florida A&M University (USA)
  • Anna University (India)
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  • Tohoku University (Japan)
  • Helmholtz Zentrum München (Germany)
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    Biological Activity
    Description: Trachelogenin has antiproliferative effect, the mechanism is related to affect the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner.
    Targets: Wnt/β-catenin | GSK-3 | c-Myc
    In vitro:
    Fitoterapia. 2015 Jan;100:19-26.
    Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line.[Pubmed: 25447161]
    The molecular constituents of Cirsium brachycephalum fruits were identified, quantified and isolated for the first time.
    The lignan glycoside tracheloside was the main compound, which was transformed quantitatively into its aglycone Trachelogenin by endogenous enzymatic treatment of the fruit. Following this transformation by high performance liquid chromatography (HPLC) hyphenated with UV and mass spectrometry (MS) detections on a quantitative basis, the enzyme-hydrolyzed fruit was found to be the richest raw material containing Trachelogenin (17.2mg/g) reported to date. Thus, the enzyme-hydrolyzed fruit was used to isolate Trachelogenin using preparative HPLC in order to (1) unambiguously confirm its identity by gas chromatography-MS, nuclear magnetic resonance spectroscopy and optical rotation, and (2) investigate its in vitro antiproliferative activities against the SW480 colon adenocarcinoma cell line.
    Trachelogenin significantly affected the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway in a concentration-dependent manner. These changes account for the antiproliferative effects of Trachelogenin.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1033-7.
    Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography/tandem mass spectrometry.[Pubmed: 21482203]
    We developed and validated a quantitative method for simultaneously determining the concentrations of tracheloside and Trachelogenin in rat plasma.
    Plasma samples were prepared by liquid-liquid extraction with ethyl acetate. Isocratic chromatographic separation was performed on a reversed-phase Diamonsil C(18) column (4.6×200 mm, 5 μm). The mobile phase consisted of methanol and 10mM aqueous ammonium formate (80:20, v/v). Analyte detection was achieved by positive electrospray ionization (ESI) tandem mass spectrometry. Calibration was performed by internal standardization with glipizide, and regression curves ranging from 0.625 to 625 ng/mL were constructed for both the analytes. The intra- and inter-day precision values were below 8%, and accuracy ranged from -5.33% to 2.53% in all quality control samples.
    In this study, the validated method was successfully applied to determine the pharmacokinetic profile of tracheloside and Trachelogenin in rat plasma after oral and intravenous administration of trachelospermi total lignans.
    Trachelogenin Description
    Source: The herbs of Trachelospermum jasminoides (Lindl.) Lem.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5763 mL 12.8816 mL 25.7632 mL 51.5265 mL 64.4081 mL
    5 mM 0.5153 mL 2.5763 mL 5.1526 mL 10.3053 mL 12.8816 mL
    10 mM 0.2576 mL 1.2882 mL 2.5763 mL 5.1526 mL 6.4408 mL
    50 mM 0.0515 mL 0.2576 mL 0.5153 mL 1.0305 mL 1.2882 mL
    100 mM 0.0258 mL 0.1288 mL 0.2576 mL 0.5153 mL 0.6441 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.