ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $53.2 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules. 2013, 18(11):14105-21BMC Complement Altern Med.2014, 14:242Asian Journal of Chemistry...2014...Anticancer Res.2014, 34(7):3505-9Phytomedicine.2015, 22(14):1262-8SBRAS2016, 12ARPN Journal of Eng.& Applied Sci...2016...Anal Bioanal Chem. 2016, 408(15)
Naunyn Schmiedebergs Arch Pharmac...2017...Pharm Biol.2017, 55(1):360-366Korean J of Medicinal Crop Scienc...2018...Phytomedicine.2018, 47:48-57Virulence.2018, 9(1):588-603J Mol Med (Berl).2018, 96(7):661-672Cell Death Dis.2019, 10(12):882World J Mens Health.2019, 10.5534
Exp Ther Med.2019, 18(6):4388-4396J Ethnopharmacol.2019, 228:132-141J Ethnopharmacol.2019, 235:406-414Int J Oncol.2019, 55(1):320-330Anal Biochem.2019, 569:10-15Industrial Crops and Products...2020...Cell Metab.2020, S1550-4131(20)30002-4
Our products had been exported to the following research institutions and universities, And still growing.
Medical University of South Car... (USA)Donald Danforth Plant Science C... (USA)Univerzita Karlova v Praze (Czech Republic)Universidade do Porto (Portugal)
Agricultural Research Organizat... (Israel)University of Padjajaran (Indonesia)Srinakharinwirot University (Thailand)University of Canterbury (New Zealand)
Wroclaw Medical University (Poland)Universitas islam negeri Jakarta (Indonesia)University of Virginia (USA)
Related Screening Libraries
||Tuberostemonine has antitussive activity, acts in part as an open-channel blocker at the crayfish neuromuscular junction; it also exhibits relatively higher intestinal permeabilities.|
|Planta Med. 2009 May;75(6):575-80. |
|Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa.[Pubmed: 19214944]|
|The intestinal absorption of four stereoisomers of Tuberostemonine-type alkaloids, neoTuberostemonine (1), Tuberostemonine (2), Tuberostemonine H (3), and Tuberostemonine J (4), isolated from the antitussive Chinese medicinal herb Radix Stemonae, and the IN VIVO antitussive activity of alkaloids 1, 2 and 3 were investigated in the current study. |
METHODS AND RESULTS:
All three alkaloids exhibited dose-dependent inhibitory effects on citric acid-induced cough in guinea pigs after intraperitoneal administration. Alkaloid 2 had the same potency via both oral and intraperitoneal dosing, 1 exhibited significantly lower oral activity than that following intraperitoneal application, while 3 did not show oral activity.
Alkaloid 4 demonstrated a moderate permeability in Caco-2 monolayer cells while alkaloids 1, 2 and 3 exhibited relatively higher intestinal permeabilities, indicating that all four alkaloids tested had reasonable oral absorption.
||The roots of Stemona japonica
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Brain Res. 1985 May 13;334(1):33-40. |
|Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction.[Pubmed: 2581668]|
METHODS AND RESULTS:
At the crayfish neuromuscular junction, Tuberostemonine, an alkaloid from Stemona japonica, reduced the amplitude of both the excitatory junctional potential (e.j.p.) and the glutamate response in a dose-dependent manner at concentrations above 0.1 mM. Tuberostemonine acted presynaptically on the crayfish neuromuscular junction to reduce a quantal content of extracellularly recorded e.j.p.s, and postsynaptically to reduce their unit size. The decay of the excitatory synaptic current was accelerated by Tuberostemonine. The gradual decline of the successive glutamate currents induced by a train was facilitated by the presence of Tuberostemonine even in the muscle fibre pre-treated with concanavalin A. The rate of recovery from the refractory form of the glutamate receptor to the free reactive one was slightly affected by Tuberostemonine when it was determined by using a paired pulse method. The inhibitory action of Tuberostemonine on glutamate responses was voltage-dependent and hyperpolarization increased the drug action.
These results indicate that Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.