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    Tuberostemonine
    Information
    CAS No. 6879-01-2 Price $148 / 20mg
    Catalog No.CFN98138Purity>=98%
    Molecular Weight375.51Type of CompoundAlkaloids
    FormulaC22H33NO4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $53.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Related Libraries
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  • Biological Activity
    Description: Tuberostemonine has antitussive activity, acts in part as an open-channel blocker at the crayfish neuromuscular junction; it also exhibits relatively higher intestinal permeabilities.
    Targets: Antifection
    In vivo:
    Planta Med. 2009 May;75(6):575-80.
    Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa.[Pubmed: 19214944]
    The intestinal absorption of four stereoisomers of Tuberostemonine-type alkaloids, neoTuberostemonine (1), Tuberostemonine (2), Tuberostemonine H (3), and Tuberostemonine J (4), isolated from the antitussive Chinese medicinal herb Radix Stemonae, and the IN VIVO antitussive activity of alkaloids 1, 2 and 3 were investigated in the current study.
    METHODS AND RESULTS:
    All three alkaloids exhibited dose-dependent inhibitory effects on citric acid-induced cough in guinea pigs after intraperitoneal administration. Alkaloid 2 had the same potency via both oral and intraperitoneal dosing, 1 exhibited significantly lower oral activity than that following intraperitoneal application, while 3 did not show oral activity.
    CONCLUSIONS:
    Alkaloid 4 demonstrated a moderate permeability in Caco-2 monolayer cells while alkaloids 1, 2 and 3 exhibited relatively higher intestinal permeabilities, indicating that all four alkaloids tested had reasonable oral absorption.
    Tuberostemonine Description
    Source: The roots of Stemona japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.663 mL 13.3152 mL 26.6304 mL 53.2609 mL 66.5761 mL
    5 mM 0.5326 mL 2.663 mL 5.3261 mL 10.6522 mL 13.3152 mL
    10 mM 0.2663 mL 1.3315 mL 2.663 mL 5.3261 mL 6.6576 mL
    50 mM 0.0533 mL 0.2663 mL 0.5326 mL 1.0652 mL 1.3315 mL
    100 mM 0.0266 mL 0.1332 mL 0.2663 mL 0.5326 mL 0.6658 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Brain Res. 1985 May 13;334(1):33-40.
    Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction.[Pubmed: 2581668]

    METHODS AND RESULTS:
    At the crayfish neuromuscular junction, Tuberostemonine, an alkaloid from Stemona japonica, reduced the amplitude of both the excitatory junctional potential (e.j.p.) and the glutamate response in a dose-dependent manner at concentrations above 0.1 mM. Tuberostemonine acted presynaptically on the crayfish neuromuscular junction to reduce a quantal content of extracellularly recorded e.j.p.s, and postsynaptically to reduce their unit size. The decay of the excitatory synaptic current was accelerated by Tuberostemonine. The gradual decline of the successive glutamate currents induced by a train was facilitated by the presence of Tuberostemonine even in the muscle fibre pre-treated with concanavalin A. The rate of recovery from the refractory form of the glutamate receptor to the free reactive one was slightly affected by Tuberostemonine when it was determined by using a paired pulse method. The inhibitory action of Tuberostemonine on glutamate responses was voltage-dependent and hyperpolarization increased the drug action.
    CONCLUSIONS:
    These results indicate that Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.