• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    CAS No. 6879-01-2 Price $148 / 20mg
    Catalog No.CFN98138Purity>=98%
    Molecular Weight375.51Type of CompoundAlkaloids
    FormulaC22H33NO4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $53.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Medical University of South Car... (USA)
  • Donald Danforth Plant Science C... (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universidade do Porto (Portugal)
  • Agricultural Research Organizat... (Israel)
  • University of Padjajaran (Indonesia)
  • Srinakharinwirot University (Thailand)
  • University of Canterbury (New Zealand)
  • Wroclaw Medical University (Poland)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Virginia (USA)
  • More...
  • Package
    Featured Products
    Ganoderic acid DM

    Catalog No: CFN99815
    CAS No: 173075-45-1
    Price: $592/5mg

    Catalog No: CFN99306
    CAS No: 119400-87-2
    Price: $398/5mg
    Polygalaxanthone III

    Catalog No: CFN90208
    CAS No: 162857-78-5
    Price: $138/20mg

    Catalog No: CFN95001
    CAS No: 1891-25-4
    Price: $358/5mg

    Catalog No: CFN95007
    CAS No: 135309-02-3
    Price: $418/5mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg

    Catalog No: CFN99710
    CAS No: 51059-44-0
    Price: $100/20mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Nematicidal Compound Library
  • Alkaloids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Tuberostemonine has antitussive activity, acts in part as an open-channel blocker at the crayfish neuromuscular junction; it also exhibits relatively higher intestinal permeabilities.
    Targets: Antifection
    In vivo:
    Planta Med. 2009 May;75(6):575-80.
    Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa.[Pubmed: 19214944]
    The intestinal absorption of four stereoisomers of Tuberostemonine-type alkaloids, neoTuberostemonine (1), Tuberostemonine (2), Tuberostemonine H (3), and Tuberostemonine J (4), isolated from the antitussive Chinese medicinal herb Radix Stemonae, and the IN VIVO antitussive activity of alkaloids 1, 2 and 3 were investigated in the current study.
    All three alkaloids exhibited dose-dependent inhibitory effects on citric acid-induced cough in guinea pigs after intraperitoneal administration. Alkaloid 2 had the same potency via both oral and intraperitoneal dosing, 1 exhibited significantly lower oral activity than that following intraperitoneal application, while 3 did not show oral activity.
    Alkaloid 4 demonstrated a moderate permeability in Caco-2 monolayer cells while alkaloids 1, 2 and 3 exhibited relatively higher intestinal permeabilities, indicating that all four alkaloids tested had reasonable oral absorption.
    Tuberostemonine Description
    Source: The roots of Stemona japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds

    Catalog No: CFN95202
    CAS No: 131623-14-8
    Price: $318/10mg

    Catalog No: CFN96588
    CAS No: 50816-24-5
    Price: $268/20mg
    Polygalin J

    Catalog No: CFN95175
    CAS No: N/A
    Price: $318/5mg

    Catalog No: CFN95171
    CAS No: 87095-77-0
    Price: $318/10mg
    Withaferin A

    Catalog No: CFN91895
    CAS No: 5119-48-2
    Price: $368/10 mg

    Catalog No: CFN96238
    CAS No: 5041-67-8
    Price: $368/5mg
    1,5-Dicaffeoylquinic acid

    Catalog No: CFN99123
    CAS No: 30964-13-7
    Price: $298/20mg

    Catalog No: CFN92125
    CAS No: 75969-83-4
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.663 mL 13.3152 mL 26.6304 mL 53.2609 mL 66.5761 mL
    5 mM 0.5326 mL 2.663 mL 5.3261 mL 10.6522 mL 13.3152 mL
    10 mM 0.2663 mL 1.3315 mL 2.663 mL 5.3261 mL 6.6576 mL
    50 mM 0.0533 mL 0.2663 mL 0.5326 mL 1.0652 mL 1.3315 mL
    100 mM 0.0266 mL 0.1332 mL 0.2663 mL 0.5326 mL 0.6658 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Animal Research:
    Brain Res. 1985 May 13;334(1):33-40.
    Inhibitory actions of tuberostemonine on the excitatory transmission at the crayfish neuromuscular junction.[Pubmed: 2581668]

    At the crayfish neuromuscular junction, Tuberostemonine, an alkaloid from Stemona japonica, reduced the amplitude of both the excitatory junctional potential (e.j.p.) and the glutamate response in a dose-dependent manner at concentrations above 0.1 mM. Tuberostemonine acted presynaptically on the crayfish neuromuscular junction to reduce a quantal content of extracellularly recorded e.j.p.s, and postsynaptically to reduce their unit size. The decay of the excitatory synaptic current was accelerated by Tuberostemonine. The gradual decline of the successive glutamate currents induced by a train was facilitated by the presence of Tuberostemonine even in the muscle fibre pre-treated with concanavalin A. The rate of recovery from the refractory form of the glutamate receptor to the free reactive one was slightly affected by Tuberostemonine when it was determined by using a paired pulse method. The inhibitory action of Tuberostemonine on glutamate responses was voltage-dependent and hyperpolarization increased the drug action.
    These results indicate that Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.