• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    CAS No. 486-64-6 Price
    Catalog No.CFN98773Purity>=98%
    Molecular Weight202.2 Type of CompoundAlkaloids
    FormulaC11H10N2O2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Sapienza University of Rome (Italy)
  • Osmania University (India)
  • Texas A&M University (USA)
  • Center for protein Engineering (... (Belgium)
  • University of Eastern Finland (Finland)
  • Kyushu University (Japan)
  • Helmholtz Zentrum München (Germany)
  • University of East Anglia (United Kingdom)
  • Molecular Biology Institute of B... (Spain)
  • Centralised Purchases Unit (CPU)... (India)
  • China Medical University (Taiwan)
  • More...
  • Package
    Featured Products

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg

    Catalog No: CFN98423
    CAS No: 3301-49-3
    Price: $238/10mg

    Catalog No: CFN98565
    CAS No: 5373-11-5
    Price: $60/20mg

    Catalog No: CFN99783
    CAS No: 484-29-7
    Price: $178/20mg

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    Biological Activity
    Description: 1. Vasicinone may act as a hepatoprotective agent.
    2. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.
    3. (S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803.
    Targets: P450 (e.g. CYP17)
    Vasicinone Description
    Source: The herbs of Peganum harmala L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Isochlorogenic acid A

    Catalog No: CFN99118
    CAS No: 2450-53-5
    Price: $108/20mg

    Catalog No: CFN95026
    CAS No: 166021-14-3
    Price: $388/10mg
    Physalin O

    Catalog No: CFN95097
    CAS No: 120849-18-5
    Price: $413/5mg

    Catalog No: CFN96504
    CAS No: 51847-92-8
    Price: $333/5mg

    Catalog No: CFN92225
    CAS No: 905954-18-9
    Price: $338/5mg
    Sibiricaxanthone B

    Catalog No: CFN90644
    CAS No: 241125-81-5
    Price: $288/20mg

    Catalog No: CFN97068
    CAS No: 62218-13-7
    Price: $318/10mg

    Catalog No: CFN92750
    CAS No: 5989-02-6
    Price: $388/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.9456 mL 24.728 mL 49.456 mL 98.912 mL 123.64 mL
    5 mM 0.9891 mL 4.9456 mL 9.8912 mL 19.7824 mL 24.728 mL
    10 mM 0.4946 mL 2.4728 mL 4.9456 mL 9.8912 mL 12.364 mL
    50 mM 0.0989 mL 0.4946 mL 0.9891 mL 1.9782 mL 2.4728 mL
    100 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9891 mL 1.2364 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Vasicinone References Information
    Citation [1]

    Indian J Exp Biol. 2014 Jul;52(7):705-11.

    Evaluation of hepatoprotective activity of vasicinone in mice.[Pubmed: 25059038]
    Justicia adhatoda (vasaka) leaves have long been used in Indian Ayurvedic system of medicine as antitussive. Its crude extract has been previously reported to have hepatoprotective activity. Vasicinone was isolated from leaves of J. adhatoda, column purified and characterized using, TLC UV, FT-IR and 1H NMR. The isolated Vasicinone was evaluated for hepatoprotective activity using (CCl4)-induced acute hepatotoxicity model in mice. CCl4 treatments lead to significant increase in SGOT, SGPT, ALP levels. Pre-treatment with Vasicinone and silymarin (25 mg/kg/day for 7 days) significantly decreased these enzyme levels. Histopathology of the livers from Vasicinone and silymarin pre-treated animals showed normal hepatic cords and absence of necrotic changes suggesting pronounced recovery from CCl4 induced liver damage. Both Vasicinone and silymarin significantly decrease the CCl4 mediated increase in pentobarbital indiced sleeping time in experimental animals, thus indicating recovery of liver function. Based on the above results it can be concluded that Vasicinone may act as hepatoprotective in mice and warrants further investigation on human volunteers.
    Citation [2]

    Phytomedicine. 2015 Nov 15;22(12):1088-95.

    Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L.[Pubmed: 26547531 ]
    The aerial parts of Peganum harmala L. (APP) is a well-known and effective herbal medicine in China, and has been commonly used for treating various ailments, including cough and asthma. OBJECTIVES: To evaluate the antitussive, expectorant, and bronchodilating effects of the quinazoline alkaloids (±)-vasicine (VAS), deoxyvasicine (DVAS) (both isolated from the alkaloid fraction of APP) and (±)-Vasicinone (VAO) (synthesized from VAS). CONCLUSIONS: Quinazoline alkaloids VAS, VAO, and DVAS have significant antitussive, expectorant, and bronchodilating activities. VAS, VAO, and DVAS are the active ingredients in APP, which can be used to treat respiratory disease.
    Citation [3]

    J Asian Nat Prod Res. 2015 May;17(5):595-600.

    Antitumor quinazoline alkaloids from the seeds of Peganum harmala.[Pubmed: 26166311 ]
    A phytochemical study on the methanol extracts from the seeds of Peganum harmala L. led to a new quizonaline alkaloid (S)-Vasicinone-1-O-β-d-glucopyranoside (1) and four known ones, (R)-Vasicinone-1-O-β-d-glucopyranoside (2), (S)-Vasicinone (3), vasicine (4), and deoxyVasicinone (5). Their structures were elucidated by spectroscopic analysis including IR, HR-ESI-MS, 1D and 2D NMR, and specific rotation as well as by comparison of the data with those in the literature. All of the alkaloids were screened for antiproliferative activity against human gastric cancer cells MCG-803 with MTT method. Compounds 1 and 3 exhibited moderate inhibitory activity.