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    Yadanziolide C
    Yadanziolide C
    Information
    CAS No. 95258-12-1 Price
    Catalog No.CFN96426Purity>=98%
    Molecular Weight410.41Type of CompoundDiterpenoids
    FormulaC20H26O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Yadanziolide C induces differentiation with cultured HL-60 promyelocytic leukemia cells.
    In vitro:
    Phytochemistry. 1996 Sep;43(2):409-12.
    A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells.[Pubmed: 8862033]

    METHODS AND RESULTS:
    A novel lignan, guaiacylglycerol-beta-O-6'-(2-methoxy)cinnamyl alcohol either, three known simaroubolides, brusatol, dehydrobrusatol, Yadanziolide C, and the known terpenoid, blumenol A, were obtained as active compounds from an ethyl acetate-soluble extract of Brucea javanica, using a bioassay based on the induction of cell differentiation with human promyelocytic leukemia (HL-60) cells.
    CONCLUSIONS:
    Also obtained were the known coumarinolignan, cleomiscosin A, and the known quassinoid glycoside, bruceoside B, which were inactive in the HL-60 cell test system. The structure of the new lignan was determined by a combination of 1D and 2D NMR techniques.
    Yadanziolide C Description
    Source: The seeds of Brucea javanica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4366 mL 12.1829 mL 24.3659 mL 48.7318 mL 60.9147 mL
    5 mM 0.4873 mL 2.4366 mL 4.8732 mL 9.7464 mL 12.1829 mL
    10 mM 0.2437 mL 1.2183 mL 2.4366 mL 4.8732 mL 6.0915 mL
    50 mM 0.0487 mL 0.2437 mL 0.4873 mL 0.9746 mL 1.2183 mL
    100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.4873 mL 0.6091 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chemical & Pharmaceutical Bulletin, 1984,32 (11) :4698-701.
    Structures of yadanziolides A, B, and C, new bitter principles from Brucea javanica.[Reference: WebLink]
    Three bitter quassinoids, yadanziolide A, yadanziolide B, and Yadanziolide C (1, 2 and 3), were isolated from seeds of Brucea javanica, known as"Ya-dan-zi" in Chinese folklore and their structures have been established from chemical transformation and spectral analysis.