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  • Science | Nature | Cell | View More
    Natural Products
    Phaseolus calcaratus

    Phaseolus calcaratus, the seed of Phaseolus calcaratus has traditionally been used as a herbal medicine. Catechin-7-O-glucoside can be found in the seed of Phaseolus calcaratus. In vitro, this compound has an antioxidant activity leading to a cytoprotective effect.
    The fractions inhibited LPS-induced nitric oxide production and cyclooxygenase-2 (COX-2) expression in the cells. The ethyl acetate fraction at 100 µg/ml almost completely suppressed NO production, iNOS and COX-2 expression, and TNF-α and IL-6 secretion in cells stimulated with LPS. The fraction also inhibited phosphorylation of extracellular signal-regulated kinase  and p38 in LPS-stimulated cells with the attendant suppression of IκBα nuclear translocation and nuclear factor (NF)-κB activation. Furthermore, PHCR seed extracts contained a large number of phenolic compounds having antioxidant potentials against 1,1-diphenyl-2-picrylhydrazyl  radicals and hydroxyl radicals. We identified catechin-7-O-β-D-glucopyranoside as one of the active compounds responsible for the biological activity of PHCR seed extract.

    Phaseolus calcaratus
    Research products of Phaseolus calcaratus
    Catalog Product Name CAS Number Manual
    CFN98964Liriodendrin573-44-4  PDF
    CFN98791Resveratrol501-36-0  PDF
    CFN98368Oxyresveratrol29700-22-9  PDF
    CFN97949Maltol118-71-8  PDF
    CFN90067Riboflavine83-88-5  PDF
    CFN90068Thiamine hydrochloride67-03-8  PDF
    CFN98665Catechin 7-xyloside42830-48-8  PDF
    CFN99052Catechin 3-rhamnoside103630-03-1  PDF
    CFN99646Catechin154-23-4  PDF
    CFN98781Epicatechin490-46-0  PDF
    CFN97549(-)-Epigallocatechin(EGC)970-74-1  PDF
    CFN99557Procyanidin B120315-25-7  PDF
    CFN99558Procyanidin B229106-49-8  PDF
    CFN99559Procyanidin B323567-23-9  PDF
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