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    Natural Products
    Catechin 7-xyloside
    Information
    CAS No. 42830-48-8 Price
    Catalog No.CFN98665Purity>=98%
    Molecular Weight422.4 Type of CompoundFlavonoids
    FormulaC20H22O10Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Catechin 7-xyloside

    Catechin 7-xyloside
    Product Name Catechin 7-xyloside
    CAS No.: 42830-48-8
    Catalog No.: CFN98665
    Molecular Formula: C20H22O10
    Molecular Weight: 422.4 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Source: The herbs of Spiraea hypericifolia L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Biological Activity
    Description: Catechin-7-O-xyloside has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.
    In vitro:
    Oncol. Rep., 2014, 31(1):314-20.
    Catechin-7-O-xyloside induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.[Pubmed: 24213951]
    The medicinal plant Ulmus davidiana var. japonica has significant potential as a cancer chemoprevention agent. Catechin 7-O-xyloside (Catechin 7-xyloside,C7Ox) was purified from ultrafine U. davidiana var. japonica ethanol extract.
    METHODS AND RESULTS:
    In the present study, we investigated the apoptotic effect of C7Ox in the non-small cell lung cancer (NSCLC) cell line H1299. C7Ox treatment induced cell death and decreased plasma membrane integrity, an event typical of apoptosis. C7Ox-induced apoptosis was associated with the proteolytic activation of caspase-6, cleavage of poly(ADP-ribose) polymerase (PARP) and loss of mitochondrial membrane potential. C7Ox also induced the endoplasmic reticulum (ER) stress-regulated pro-apoptotic transcription factor CHOP. The suppression of CHOP expression significantly decreased C7Ox-induced cell death, LDH leakage and caspase-6 activation. Antitumor effects, evaluated based on protracted tumor regression, were observed when nude-mice bearing H1299 xenografts were treated with C7Ox. C7Ox-induced tumor regression was accompanied by enhanced expression of CHOP mRNA.
    CONCLUSIONS:
    Our data suggest that C7Ox can trigger mitochondrial-mediated apoptosis, and that ER stress is critical for C7Ox-induced apoptosis in H1299 NSCLC cells.
    Catechin 7-xyloside Description
    Source: The herbs of Spiraea hypericifolia L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3674 mL 11.8371 mL 23.6742 mL 47.3485 mL 59.1856 mL
    5 mM 0.4735 mL 2.3674 mL 4.7348 mL 9.4697 mL 11.8371 mL
    10 mM 0.2367 mL 1.1837 mL 2.3674 mL 4.7348 mL 5.9186 mL
    50 mM 0.0473 mL 0.2367 mL 0.4735 mL 0.947 mL 1.1837 mL
    100 mM 0.0237 mL 0.1184 mL 0.2367 mL 0.4735 mL 0.5919 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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