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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Ind Crops Prod.2015, 67:185-191Mol Cell.2017, 68(4):673-685Viruses.2017, 9(10)Br J Pharmacol.2018, 175(6):902-923Evid Based Complement Alternat Me...2018...Nat Prod Sci.2018, 24(3):206Pak J Pharm Sci.2018, 31:311-315J Cancer.2019, 10(23):5843-5851
Front Microbiol.2019, 10:2806Microb Pathog.2019, 131:128-134BMC Complement Altern Med....2019...J Ethnopharmacol.2019, 236:31-41Molecules.2019, 24(2):E343Molecules.2019, 24(4):E744Molecules.2019, 24(6):E1177Chem Pharm Bull (Tokyo)....2019...
Comput Biol Chem.2019, 83:107096Plant Foods Hum Nutr.2020, 10.1007Food Chem Toxicol.2020, 135:110863Biochem Pharmacol.2020, 178:114083J Agric Food Chem....2020...Pharmacol Rep.2020, 72(2):472-480.Functional Ecology2020, doi: 10.1111.
Our products had been exported to the following research institutions and universities, And still growing.
Kazusa DNA Research Institute (Japan)University of Fribourg (Switzerland)University of Helsinki (Finland)University of the Basque Country (Spain)
CSIRO - Agriculture Flagship (Australia)Donald Danforth Plant Science C... (USA)University of Mysore (India)VIB Department of Plant Systems... (Belgium)
University of Bordeaux (France)Subang Jaya Medical Centre (Malaysia)Funda??o Universitária de Dese... (Brazil)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Metabolites.2019, 9(11):E271Toxicol In Vitro.2018, 52:94-105Sci Rep.2019, 9(1):4342Molecules.2020, 25(21):5087. J Sep Sci.2018, 41(7):1682-1690Nutrients2020, 12(2):488Evid Based Complement Alternat Med.2020, 2020:2584783.Viruses.2017, 9(10)Pharmacognosy Journal2019, 11(2): 369-373Cell Physiol Biochem.2017, 44(4):1381-1395
Related Screening Libraries
||Catechin-7-O-xyloside has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.|
|Oncol. Rep., 2014, 31(1):314-20. |
|Catechin-7-O-xyloside induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.[Pubmed: 24213951]|
|The medicinal plant Ulmus davidiana var. japonica has significant potential as a cancer chemoprevention agent. Catechin 7-O-xyloside (Catechin 7-xyloside,C7Ox) was purified from ultrafine U. davidiana var. japonica ethanol extract. |
METHODS AND RESULTS:
In the present study, we investigated the apoptotic effect of C7Ox in the non-small cell lung cancer (NSCLC) cell line H1299. C7Ox treatment induced cell death and decreased plasma membrane integrity, an event typical of apoptosis. C7Ox-induced apoptosis was associated with the proteolytic activation of caspase-6, cleavage of poly(ADP-ribose) polymerase (PARP) and loss of mitochondrial membrane potential. C7Ox also induced the endoplasmic reticulum (ER) stress-regulated pro-apoptotic transcription factor CHOP. The suppression of CHOP expression significantly decreased C7Ox-induced cell death, LDH leakage and caspase-6 activation. Antitumor effects, evaluated based on protracted tumor regression, were observed when nude-mice bearing H1299 xenografts were treated with C7Ox. C7Ox-induced tumor regression was accompanied by enhanced expression of CHOP mRNA.
Our data suggest that C7Ox can trigger mitochondrial-mediated apoptosis, and that ER stress is critical for C7Ox-induced apoptosis in H1299 NSCLC cells.
Catechin 7-xyloside Description
||The herbs of Spiraea hypericifolia L.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.