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    Natural Products
    1,3-Dicaffeoylquinic acid
    1,3-Dicaffeoylquinic acid
    Information
    CAS No. 19870-46-3 Price $198 / 20mg
    Catalog No.CFN90937Purity>=98%
    Molecular Weight516.5Type of CompoundPhenylpropanoids
    FormulaC25H24O12Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $92.7 / In-stock
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    1,3-Dicaffeoylquinic acid

    1,3-Dicaffeoylquinic acid
    Product Name 1,3-Dicaffeoylquinic acid
    CAS No.: 19870-46-3
    Catalog No.: CFN90937
    Molecular Formula: C25H24O12
    Molecular Weight: 516.5 g/mol
    Purity: >=98%
    Type of Compound: Phenylpropanoids
    Physical Desc.: Powder
    Targets: ROS | hOAT3
    Source: The herbs of Cynara scolymus L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $198 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • Molecules.2019, 24(6):E1155
  • Academic J of Second Military Medical University2019, 40(1)
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Phytother Res.2020, 34(4):788-795.
  • Antiviral Res.2013, 98(3):386-93
  • Current Pharmaceutical Analysis2017, 13(5)
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Exp Neurobiol.2018, 27(3):200-209
  • J Nat Prod.2018, 81(4):966-975
  • Free Radic Biol Med.2017, 112:191-199
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
  • Inhibitors Compound Library
  • Phenylpropanoids Compound Library
  • ROS Inhibitor Library
  • Biological Activity
    Description: 1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.It can significantly inhibit hOAT3 transport under similar conditions.
    Targets: ROS | hOAT3
    In vitro:
    Food Research International, 2009 , 42 (9) :1273-1280.
    Antioxidant activity of 1,3-dicaffeoylquinic acid isolated from Inula viscosa.[Reference: WebLink]
    Inula viscosa is a perennial herbaceous plant used topically in folk medicine as an anti-scabies, anti-inflammatory, and wound-healing agent.
    METHODS AND RESULTS:
    We examined the antioxidant activity of the methanolic extract of I. viscosa. We isolated and identified several polyphenolic antioxidants from I. viscosa leaves and focused on 1,3-Dicaffeoylquinic acid (1,3-diCQA). Antioxidant activity was measured using ABTS and DPPH assays, which measure antioxidant activity. The concentrations of 1,3-diCQA required for the inhibition of oxidation were lower than those required by other known antioxidants. 1,3-diCQA inhibited oxidative damage caused by various factors, including FeSO4 and AAPH (2,2'-azobis(2-amidinopropane) dehydrochloride). Antioxidant activity can also be detected by the ability of a compound to scavenge reactive oxygen species (ROS). 1,3-diCQA was found to scavenge hydroxyl radical and superoxide radicals, as measured by electron spin resonance (ESR).
    CONCLUSIONS:
    These data demonstrate that 1,3-diCQA exhibits antioxidant properties, probably through the involvement of a direct scavenging effect on several free radicals.
    In vivo:
    Evid Based Complement Alternat Med. 2013;2013:612527.
    Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).[Pubmed: 23573138]
    Active components of complementary/alternative medicines and natural supplements are often anionic compounds and flavonoids. As such, organic anion transporters (OATs) may play a key role in their pharmacokinetic and pharmacological profiles, and represent sites for adverse drug-drug interactions.
    METHODS AND RESULTS:
    Therefore, we assessed the inhibitory effects of nine natural products, including flavonoids (catechin and epicatechin), chlorogenic acids (1,3-Dicaffeoylquinic acid and 1,5-dicaffeoylquinic acid), phenolic acids (ginkgolic acids (13 : 0), (15 : 1), and (17 : 1)), and the organic acids ursolic acid and 18 β -glycyrrhetinic acid, on the transport activity of the human OATs, hOAT1 (SLC22A6), hOAT3 (SLC22A8), and hOAT4 (SLC22A11). Four compounds, 1,3- and 1,5-dicaffeoylquinic acid, ginkgolic acid (17 : 1), and 18 β -glycyrrhetinic acid, significantly inhibited hOAT1-mediated transport (50  μ M inhibitor versus 1  μ M substrate). Five compounds, 1,3- and 1,5-dicaffeoylquinic acid, ginkgolic acids (15 : 1) and (17 : 1), and epicatechin, significantly inhibited hOAT3 transport under similar conditions. Only catechin inhibited hOAT4. Dose-dependency studies were conducted for 1,3-Dicaffeoylquinic acid and 18 β -glycyrrhetinic acid on hOAT1, and IC50 values were estimated as 1.2 ± 0.4  μ M and 2.7 ± 0.2  μ M, respectively.
    CONCLUSIONS:
    These data suggest that 1,3-Dicaffeoylquinic acid and 18 β -glycyrrhetinic acid may cause significant hOAT1-mediated DDIs in vivo; potential should be considered for safety issues during use and in future drug development.
    1,3-Dicaffeoylquinic acid Description
    Source: The herbs of Cynara scolymus L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9361 mL 9.6805 mL 19.3611 mL 38.7222 mL 48.4027 mL
    5 mM 0.3872 mL 1.9361 mL 3.8722 mL 7.7444 mL 9.6805 mL
    10 mM 0.1936 mL 0.9681 mL 1.9361 mL 3.8722 mL 4.8403 mL
    50 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3872 mL 0.484 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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