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    Natural Products
    12-Hydroxysapriparaquinone
    Information
    CAS No. 142763-37-9 Price
    Catalog No.CFN92244Purity>=98%
    Molecular Weight312.4Type of CompoundDiterpenoids
    FormulaC20H24O3Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    12-Hydroxysapriparaquinone

    12-Hydroxysapriparaquinone
    Product Name 12-Hydroxysapriparaquinone
    CAS No.: 142763-37-9
    Catalog No.: CFN92244
    Molecular Formula: C20H24O3
    Molecular Weight: 312.4 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Source: The roots of Salvia prionitis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Diterpenoids Compound Library
  • Biological Activity
    Description: 12-Hydroxysapriparaquinone is a natural product from Salvia prionitis.
    In vivo:
    Records of Natural Products, 2007 , 1 (1) :1-16.
    Biological activity of diterpenoids isolated from Anatolian Lamiaceae Plants[Reference: WebLink]

    METHODS AND RESULTS:
    Since Salvia species, especially Chinese sage S. milthiorrhiza has been used in the treatment of coronary heart diseases, Prof. Ulubelen group also investigated cardiovascular properties of several Salvia extracts (S. amplexicaulis, S. eriophora and S. syriaca) and their constituents in vivo, on Wistar Albino rats [5, 40-42]. The crude extract of S. eriophora and isolated eleven diterpenoids ferruginol (11), aethiopinone (56), 4,12-dihydroxysapriparaquinone (63), 6,7-didehydroroyleanone (64) and 4,14-dihydroxysaprorthoquinone (65), horminone, acetylhorminone, salvipisone, 12-Hydroxysapriparaquinone, 3,12-dihydroxysapri-paraquinone-1-ene, salvilimbinol, were tested [40] for cardiovascular activity.
    CONCLUSIONS:
    Among the tested abietanes, compounds 65, 56, 11, 63 and 64 as well as the crude extract showed antihypertensive activity, especially ferruginol, aethiopinone and 4,12- dihydroxysapriparaquinone by significantly reducing arterial blood pressure, and this activity is considered probably due to the vasorelaxation activity [5].
    12-Hydroxysapriparaquinone Description
    Source: The roots of Salvia prionitis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.201 mL 16.0051 mL 32.0102 mL 64.0205 mL 80.0256 mL
    5 mM 0.6402 mL 3.201 mL 6.402 mL 12.8041 mL 16.0051 mL
    10 mM 0.3201 mL 1.6005 mL 3.201 mL 6.402 mL 8.0026 mL
    50 mM 0.064 mL 0.3201 mL 0.6402 mL 1.2804 mL 1.6005 mL
    100 mM 0.032 mL 0.1601 mL 0.3201 mL 0.6402 mL 0.8003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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