7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one | CAS:100667-52-5

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

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Description:

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD).

Targets:

Amyloid-β | PI3K | mTOR

In vitro:

Biol Pharm Bull. 2016 Dec 1;39(12):1961-1967.

7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity.[Pubmed: 27615431 ]

Amyloid-β (Aβ) is one of the major causative agents of Alzheimer's disease (AD), the most common neurodegenerative disorder characterized by progressive cognitive impairment. While effective drugs for AD are currently limited, identifying anti-Aβ compounds from natural products has been shown as a promising strategy which may lead to breakthroughs for new drug candidate discovery. We have previously reported that 7-(4-hydroxyphenyl)-1-phenyl-4E-hepten-3-one (7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one ,AO-1), a diarylheptanoid extracted from the plant Alpinia officinarum, has strong effects on neuronal differentiation and neurite outgrowth in vitro and in vivo.
METHODS AND RESULTS:
The present study further uncovers that AO-1 exerts neuroprotective effects against the neurotoxicity caused by Aβ. Under the damage of Aβ oligomers, the major pathological forms of Aβ, dendrites of neurons become atrophic and simplified, but such impairments were substantially alleviated by AO-1 treatment. Moreover, AO-1 reduced apoptotic levels and oxidative stress triggered by Aβ. Further analysis showed that the anti-caspase and dendrite protective effects of AO-1 were dependent on activation of phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) pathways.
CONCLUSIONS:
These findings collectively identify AO-1 as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of AD.

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Description

Source:	The rhizomes of Curcuma longa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
Price:	$318 / 5mg
CAS No.:	100667-52-5
Catalog No.:	CFN95140
Molecular Formula:	C₁₉H₂₀O₂
Molecular Weight:	280.4 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The rhizomes of Curcuma longa L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library PI3K Inhibitor Library mTOR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5663 mL	17.8317 mL	35.6633 mL	71.3267 mL	89.1583 mL
5 mM	0.7133 mL	3.5663 mL	7.1327 mL	14.2653 mL	17.8317 mL
10 mM	0.3566 mL	1.7832 mL	3.5663 mL	7.1327 mL	8.9158 mL
50 mM	0.0713 mL	0.3566 mL	0.7133 mL	1.4265 mL	1.7832 mL
100 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.7133 mL	0.8916 mL

CFN95227	(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol	232261-31-3	282.4	C₁₉H₂₂O₂
CFN97433	5-Hydroxy-1,7-diphenyl-6-hepten-3-one	87095-74-7	280.4	C₁₉H₂₀O₂
CFN95135	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)	79559-61-8	328.4	C₂₀H₂₄O₄
CFN95602	Oxyphyllacinol	87657-77-0	314.4	C₂₀H₂₆O₃
CFN95555	Yakuchinone A	78954-23-1	312.4	C₂₀H₂₄O₃
CFN92686	Alpinoid D	1041740-13-9	308.4	C₂₀H₂₀O₃
CFN92257	Daphnenone	936006-13-2	252.3	C₁₇H₁₆O₂
CFN92628	3-Hydroxy-1,5-diphenyl-1-pentanone	60669-64-9	254.3	C₁₇H₁₈O₂
CFN92258	Daphneolone	54835-64-2	270.3	C₁₇H₁₈O₃
CFN92685	1,7-Diphenyl-4-hepten-3-one	79559-59-4	264.4	C₁₉H₂₀O