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2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran
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Product Name 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran
Price:
CAS No.: 67736-22-5
Catalog No.: CFN89263
Molecular Formula: C14H10O4
Molecular Weight: 242.23 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The aerial parts of Lespedeza cyrtobotrya.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. It also shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acts as a competitive inhibitor.
Targets: Tyrosinase
In vitro:
J Microbiol Biotechnol. 2010 Jun;20(6):988-94.
The melanin synthesis inhibition and radical scavenging activities of compounds isolated from the aerial part of Lespedeza cyrtobotrya.[Pubmed: 20622497]
The EtOAc fraction of Lespedeza cyrtobotrya showed mushroom tyrosinase inhibitory and radical scavenging activity.
METHODS AND RESULTS:
Four active compounds were isolated based on LH-20 chromatography and HPLC, and the structures were elucidated on the basis of their LC-MS and NMR spectral data, as 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), and dalbergioidin (4), respectively. 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1) showed mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acted as a competitive inhibitor. Furthermore, 37.3 micronM of compound 1 reduced 50 % of the melanin content on a human melanoma (MNT-1) cells. The radical scavenging activity of 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (1), eriodictyol-7-O-glucopyranoside (2), haginin A (3), and dalbergioidin (4) was shown with IC50 values of 11.0, 24.5, 9.0 and 36.5 micronM in an ABTS system and with IC50 values of 42.7, 36.0, 37.7 and 61.7 micronM in a DPPH system, respectively.
CONCLUSIONS:
The mushroom tyrosinase inhibitory activity of EtOAc fraction of Lespedeza cyrtobotrya was contributed by compound 1, 3 and 4, and radical scavenging activity of it was contributed by compound 1-4.
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran Description
Source: The aerial parts of Lespedeza cyrtobotrya.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1283 mL 20.6415 mL 41.2831 mL 82.5662 mL 103.2077 mL
5 mM 0.8257 mL 4.1283 mL 8.2566 mL 16.5132 mL 20.6415 mL
10 mM 0.4128 mL 2.0642 mL 4.1283 mL 8.2566 mL 10.3208 mL
50 mM 0.0826 mL 0.4128 mL 0.8257 mL 1.6513 mL 2.0642 mL
100 mM 0.0413 mL 0.2064 mL 0.4128 mL 0.8257 mL 1.0321 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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