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    Natural Products
    Licoricesaponin H2
    Licoricesaponin H2
    Information
    CAS No. 118441-85-3 Price $218 / 10mg
    Catalog No.CFN95173Purity>95%
    Molecular Weight822.92Type of CompoundTriterpenoids
    FormulaC42H62O16Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $295.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Licoricesaponin H2

    Licoricesaponin H2
    Product Name Licoricesaponin H2
    CAS No.: 118441-85-3
    Catalog No.: CFN95173
    Molecular Formula: C42H62O16
    Molecular Weight: 822.92 g/mol
    Purity: >95%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The roots of Glycyrrhiza glabra L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $218 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Triterpenoids Compound Library
  • Biological Activity
    Description: Reference standards.
    In vitro:
    Nat Prod Res. 2017 Mar;31(6):691-695.
    Antimutagenic components in Glycyrrhiza against N-methyl-N-nitrosourea in the Ames assay.[Pubmed: 27466044 ]
    Antimutagenesis against N-nitroso compounds contribute to prevention of human cancer. We have found that Glycyrrhiza aspera ethanolic extract exhibits antimutagenic activity against N-methyl-N-nitrosourea (MNU) using the Ames assay with Salmonella typhimurium TA1535.
    METHODS AND RESULTS:
    In the present study, eight purified components from Glycyrrhiza, namely glabridin, glycyrrhetinic acid, glycyrrhizin, licochalcone A, Licoricesaponin H2 , licoricesaponin G2, liquiritigenin and liquiritin were evaluated for their antimutagenicity against MNU in the Ames assay with S. typhimurium TA1535. Glycyrrhetinic acid, glycyrrhizin, licoricesaponin G2, Licoricesaponin H2 and liquiritin did not show the antimutagenicity against MNU in S. typhimurium TA1535. Glabridin, licochalcone A and liquiritigenin reduced revertant colonies derived from MNU in S. typhimurium TA1535 without showing cytotoxic effects, indicating that these compounds possess antimutagenic activity against MNU. The inhibitory activity of glabridin and licochalcone A was more effective than that of liquiritigenin.
    CONCLUSIONS:
    Thus, Glycyrrhiza contains antimutagenic components against DNA alkylating, direct-acting carcinogens.
    Licoricesaponin H2 Description
    Source: The roots of Glycyrrhiza glabra L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2152 mL 6.0759 mL 12.1518 mL 24.3037 mL 30.3796 mL
    5 mM 0.243 mL 1.2152 mL 2.4304 mL 4.8607 mL 6.0759 mL
    10 mM 0.1215 mL 0.6076 mL 1.2152 mL 2.4304 mL 3.038 mL
    50 mM 0.0243 mL 0.1215 mL 0.243 mL 0.4861 mL 0.6076 mL
    100 mM 0.0122 mL 0.0608 mL 0.1215 mL 0.243 mL 0.3038 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Biol Pharm Bull. 2005 Jan;28(1):161-4.
    Phylogenetic relationship of Glycyrrhiza lepidota, American licorice, in genus Glycyrrhiza based on rbcL sequences and chemical constituents.[Pubmed: 15635184 ]

    METHODS AND RESULTS:
    Two known saponins, licorice-saponin H2 and macedonoside A, were isolated from the stolons of Glycyrrhiza lepidota (American licorice) as major saponins. Since Licoricesaponin H2 and macedonoside A are minor saponins isolated from the three glycyrrhizin-producing species (i.e. G. glabra, G. uralensis, G. inflata) and the three macedonoside C-producing species (i.e. G. macedonica, G. echinata, G. pallidiflora), respectively, the present study suggests that G. lepidota is an intermediate of both glycyrrhizin-producing and macedonoside C-producing species.
    CONCLUSIONS:
    The phylogenetic tree constructed from the nucleotide sequences of ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit gene (rbcL) of these seven Glycyrrhiza plants indicated that G. lepidota was separated from the other six Glycyrrhiza species, and this phylogenetic relationship was in accordance with their saponin compositions.
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