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    Natural Products
    2''-O-Rhamnosylicariside II
    Information
    CAS No. 135293-13-9 Price $238 / 5mg
    Catalog No.CFN92551Purity>=98%
    Molecular Weight660.7Type of CompoundFlavonoids
    FormulaC33H40O14Physical DescriptionYellow powder
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $309.4 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    2''-O-Rhamnosylicariside II

    2''-O-Rhamnosylicariside II
    Product Name 2''-O-Rhamnosylicariside II
    CAS No.: 135293-13-9
    Catalog No.: CFN92551
    Molecular Formula: C33H40O14
    Molecular Weight: 660.7 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Source: The herbs of Epimedium brevicornu
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $238 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Toxicol Res.2019, 35(4):371-387
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: 2″-O-Rhamnosylicariside II shows potent antioxidant activity, with IC50 values of 11.5 ug/mL and 90.5 uM. It shows potent inhibitory activities on osteoclast-like cell formation at a concentration of 2 uM without toxic effects.
    In vitro:
    Journal of Traditional Medicines, 2007, 24:19-23.
    Inhibitory effect of constituents of Bu-Shen-Jian-Gu-Tang on osteoclast-like cell formation[Reference: WebLink]
    The constituents of Bu-Shen-Jian-Gu-Tang and their inhibitory activities on osteoclast-Iike cell formation were investigated. Bu-Shen-Jian-Gu-Tang was fractionated by a Diaion HP-20 column with EtOH-H_2O, and the 60% and 90% EtOH-H_20 fractions showed more potent inhibitory activities on osteoclast-like cell formation and bone resorption.
    METHODS AND RESULTS:
    Chemical investigation of these two fractions resulted in the isolation of 11 compounds, for which the structures were elucidated based on spectroscopic analysis and chemical reactions. The inhibitory activities of the isolated compounds on osteoclast-like cell formation were evaluated. Among the eleven compounds, icariin (1), icarisid II (2), 2''-O-Rhamnosylicariside II (3), kaempferol (8), chikusetsusaponin IVa (10) and chikusetsusaponin V (11) showed potent inhibitory activities at a concentration of 2 μM without toxic effects.
    CONCLUSIONS:
    The preventive effect of Bu-Shen-Jian-Gu-Tang on bone loss may be due to the inhibitory activities of these compounds.
    Natural Product Sciences, 2008, 14(4):233-8.
    Flavonol Glycosides with Antioxidant Activity from the Aerial Parts of Epimedium koreanum Nakai[Reference: WebLink]
    The aerial parts of Epimedium koreanum Nakai have been used to stimulate hormone secretion in treating impotence.
    METHODS AND RESULTS:
    Ten flavonol glycosides, 3,4,5-trihydroxy-8-prenylflavone 7-O-[β-D-glucopyranosyl(1 → 2)-β-D-glucopyranoside] (1), hyperoside (2), icarisid II (3), 2''-O-Rhamnosylicariside II (4), epimedin A (5), epimedin B (6), epimedin C (7), icariin (8), hexandraside E (9), and epimedoside A (10) were isolated from the an ethylacetate soluble extracts of the aerial parts of Epimedium koreanum Nakai through activity-monitord fractionation and isolation method. The structures of compounds 1 - 10 were elucidated by high resolution fast atom bombardment mass spectrometry and two dimentional nuclear magnetic resonance spectroscopy analysis.
    CONCLUSIONS:
    Compounds 1 and 4 showed potent antioxidant activity, with IC50 values of 19.7 and 11.5 μg/mL and 88.2 and 90.5 μM, respectively.
    2''-O-Rhamnosylicariside II Description
    Source: The herbs of Epimedium brevicornu
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5135 mL 7.5677 mL 15.1355 mL 30.2709 mL 37.8387 mL
    5 mM 0.3027 mL 1.5135 mL 3.0271 mL 6.0542 mL 7.5677 mL
    10 mM 0.1514 mL 0.7568 mL 1.5135 mL 3.0271 mL 3.7839 mL
    50 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.6054 mL 0.7568 mL
    100 mM 0.0151 mL 0.0757 mL 0.1514 mL 0.3027 mL 0.3784 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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