| In vivo: |
| Acta Pharm. Sin., 2007, 28(4):584-90. | | Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy.[Pubmed: 17376300] |
To develop a novel, in situ gel system for nasal delivery of Scopolamine hydrobromide (SCOP) and study its efficacy on motion sickness.
METHODS AND RESULTS:
SCOP in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in terms of viscosity, in vitro release, and nasal ciliotoxicity. Single photon emission computing tomography technique was used to evaluate the nasal residence time of gel containing (99m)Tc tracer. The antimotion sickness efficacy produced by the in situ gel formulation was investigated in rats and compared with those achieved after subcutaneous and oral administration.
The viscosity of the gellan gum formulations either in solution or in gel increased with increasing concentrations of gellan gum. Its release in vitro was moderate in artificial nasal fluid. The micrographic results showed that in situ gels were safe, without nasal ciliotoxicity. In comparison with phosphate buffer saline, a prolonged radioactivity of (99m)Tc in the rabbit nasal cavity was observed after administration of the gellan gum formulation. Intranasal SCOP in situ gel at a dose of 100 microg/kg decreased symptoms of motion sickness significantly in comparison with subcutaneous and oral administration (P<0.01).
CONCLUSIONS:
SCOP nasal in situ gel is a safe and promising therapeutic alternative to existing medications for motion sickness. | | Acta Academiae Medicinae Shandong, 2002(3). | | The antagonistic effects of NaHC03 and scopolamine hydrobromide to TTX poisoning in mice[Reference: WebLink] | To explore the antagonistic effects of some compounds to TTX poisoning in mice.
METHODS AND RESULTS:
The death time of mice was determined, after ip injection with TTX and some other compounds. Results: NaHCO 3 and Scopolamine hydrobromide showed markedly antagonistic effect to TTX poisoning in mice, and saved the lives of mice by 80% to 100%(P0.01). The antagonistic effect of NaHCO3 to TTX poisoning was better than that of Scopolamine hydrobromide. However atropine and L-cysteine did not show sighificant effect in the treatment of TTX poisoning.
CONCLUSIONS:
NaHCO3 and Scopolamine hydrobromide can be used to treat TTX poisoning. |
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