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    Natural Products
    21-O-Tigloylgymnemagenin
    21-O-Tigloylgymnemagenin
    Information
    CAS No. 1581276-63-2 Price $268 / 5mg
    Catalog No.CFN90978Purity>=98%
    Molecular Weight588.81Type of CompoundTriterpenoids
    FormulaC35H56O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $308.2 / In-stock
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    21-O-Tigloylgymnemagenin

    21-O-Tigloylgymnemagenin
    Product Name 21-O-Tigloylgymnemagenin
    CAS No.: 1581276-63-2
    Catalog No.: CFN90978
    Molecular Formula: C35H56O7
    Molecular Weight: 588.81 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The leaves of Gymnema sylvestre.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $268 / 5mg
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    Description: Reference standards.
    21-O-Tigloylgymnemagenin Description
    Source: The leaves of Gymnema sylvestre.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6983 mL 8.4917 mL 16.9834 mL 33.9668 mL 42.4585 mL
    5 mM 0.3397 mL 1.6983 mL 3.3967 mL 6.7934 mL 8.4917 mL
    10 mM 0.1698 mL 0.8492 mL 1.6983 mL 3.3967 mL 4.2459 mL
    50 mM 0.034 mL 0.1698 mL 0.3397 mL 0.6793 mL 0.8492 mL
    100 mM 0.017 mL 0.0849 mL 0.1698 mL 0.3397 mL 0.4246 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1997, 45(10):1671-1676.
    Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b.[Reference: WebLink]
    Although the glycosidic fraction from the dried leaves of Gymnema sylvestre R. BR., gymnemic acid, was reported to be effective for diabetes, it showed little inhibitory activity on the increase of serum glucose level in oral glucose-loaded rats.
    METHODS AND RESULTS:
    From the glycosidic fraction, six triterpene glycosides, gymnemosides a, b, c, d, e, and f, were isolated together with nine known triterpene glycosides. The structures of gymnemosides a and b were determined on the basis of chemical and physicochemical evidence as 21-O-tigloyl-22-O-acetylgymnemagenin 3-O-beta-D-glucopyranosiduronic acid and 16-O-acetyl-21-O-Tigloylgymnemagenin 3-O-beta-D-glucopyranosiduronic acid, respectively. In addition, an acetyl group linked to the 16- or 22-hydroxyl group in gymnemosides a and b was found to migrate easily to the primary 28-hydroxyl group, while the acyl migration from the 28-position was rarely observed.
    CONCLUSIONS:
    The inhibitory activity of each triterpene glycoside from gymnemic acid was examined to determine its impact on the increase of serum glucose level in oral glucose-loaded rats. Gymnemoside b and gymnemic acids III, V, and VII were found to exhibit a little inhibitory activity against glucose absorption, but the principal constituents, gymnemic acid I and gymnemasaponin V, lacked this activity.
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