ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Dichotomine B
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $324.1 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Int J Pharmacol2020, 16:1-9Food Chem.2020, 327:126992.Natural Product Communications...2020...Front Pharmacol.2021, 12:607403.Oxid Med Cell Longev....2020...J Sep Sci.2020, 201901140Biochem Biophys Res Commun....2018...Int J Mol Sci. 2014, 15(5):8443-57
The Japan Society for Analy. Chem...2017...Sci Rep.2018, 8:15059Chemistry of Plant Materials....2019...University of Guelph2021, 12.Advances in Traditional Medicine ...2021...Life Sci.2018, 209:498-506Food Res Int.2018, 106:909-919Chemistry of Vegetable Raw Materi...2019...
Biomed Pharmacother.2021, 139:111585. Food Quality and Safety2018, 2:213-219Plants (Basel).2021, 10(11):2317. J Chem Inf Model....2021...Integr Cancer Ther.2018, 17(3):832-843Int J Immunopathol Pharmacol....2019...Toxins (Basel).2021, 13(12):898.
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Our products had been exported to the following research institutions and universities, And still growing.
National Research Council of Ca... (Canada)Chang Gung University (Taiwan)University of Fribourg (Switzerland)Kamphaengphet Rajabhat University (Thailand)
Subang Jaya Medical Centre (Malaysia)Imperial College London (United Kingdom)University of Cincinnati (USA)Research Unit Molecular Epigene... (Germany)
Cornell University (USA)National Chung Hsing University (Taiwan)Monash University Sunway Campus (Malaysia)
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Dichotomine B
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Eur J Pharmacol.2021, 906:174220.J Ginseng Res.2020, 44(4):611-618.Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083Molecules2020, 25(4):892Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373J Sep Sci.2020, 201901140Phytomedicine.2021, 2(82):153452Front Neurosci.2019, 13:1091Integr Cancer Ther.2018, 17(3):832-843Molecules.2020, 25(18),4089.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Alkaloids Compound Library |
| Description: |
Reference standards. |
Dichotomine B Description
| Source: |
The herbs of Stellaria dichotoma |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.6724 mL |
18.3621 mL |
36.7242 mL |
73.4484 mL |
91.8105 mL |
| 5 mM |
0.7345 mL |
3.6724 mL |
7.3448 mL |
14.6897 mL |
18.3621 mL |
| 10 mM |
0.3672 mL |
1.8362 mL |
3.6724 mL |
7.3448 mL |
9.1811 mL |
| 50 mM |
0.0734 mL |
0.3672 mL |
0.7345 mL |
1.469 mL |
1.8362 mL |
| 100 mM |
0.0367 mL |
0.1836 mL |
0.3672 mL |
0.7345 mL |
0.9181 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| J Nat Prod. 2004 Sep;67(9):1464-9. | | Structures of new beta-carboline-type alkaloids with antiallergic effects from Stellaria dichotoma(1,2).[Pubmed: 21090796 ] | The aqueous ethanolic extract from the roots of Stellaria dichotoma showed an antiallergic effect on ear passive cutaneous anaphylaxis (PCA) reaction in mice (in vivo) and inhibitory activity on the release of beta-hexosaminidase in RBL-2H3 cells (in vitro).
METHODS AND RESULTS:
From the aqueous ethanolic extract, new beta-carboline-type alkaloids, dichotomine A (1), Dichotomine B (2), dichotomine C (3), and dichotomine D (4) and dichotomides I (5) and II (6), were isolated. The structures of the new constituents (1-6) were determined on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method.
CONCLUSIONS:
The effects of the isolated constituents on the release of beta-hexosaminidase in RBL-2H3 cells were examined, and 3 was found to show inhibitory activity (IC(50) = 62 microM). Moreover, 3 also inhibited the releases of antigen-IgE-mediated TNF-alpha and IL-4 (19 and 15 microM, respectively) in RBL-2H3 cells, both of which participate in the late phase of type I allergic reactions. |
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