25S-Inokosterone | CAS:19595-18-7 | Manufacturer ChemFaces

25S-Inokosterone

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Size /Price /Stock	10 mM * 1 mL in DMSO / $206.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.

Targets:

TNF-α | IFN-γ

In vitro:

Journal of Applied Biological Chemistry, 2015 , 58 (1) :13-19.

Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity[Reference: WebLink]

The roots of Achyranthes japonica Nakai were extracted with 100% aqueous and concentrated subfraction was separated with ultra-performance liquid chromatography-based activity profiling.
METHODS AND RESULTS:
Three compounds were isolated from the subfraction 5 through the repeated prep- high performance liquid chromatography column chromatography. According to the results of physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compounds were determined as ecdysterone (1), 25S-Inokosterone (2), and 25R-inokosterone (3). Three phytoecdysones were showed weak inhibitory activity for thymus and activation-regulated chemokine expression levels in tumor necrosis factor (TNF)-α plus IFN-γ induced HaCaT cells, respectively. However, those compounds 1-3 were exhibited the most potent inhibition (80–95% at 200 μg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells.
CONCLUSIONS:
As result, 100% aqueous extract of A. japonica has an excellent anti-atopy activity. It could be used to a large range of functional anti-atopy cosmetics.

In vivo:

Arch Pharm Res . 2012 Aug;35(8):1449-55.

High performance liquid chromatography used for quality control of Achyranthis Radix[Pubmed: 22941488]

Abstract To establish a standard of quality control and to identify reliable Achyranthis Radix, three phytoecdysones including ecdysterone (1), 25R-inokosterone (2) and 25S-Inokosterone (3) were determined by quantitative HPLC/UV analysis. Three phytoecdysones were separated with an YMC J'sphere ODS C(18) column (250 mm × 4.6 mm, 4 μm) by isocratic elution using 0.1% formic acid in water and acetonitrile (85:15, v/v%) as the mobile phase. The flow rate was 1.0 mL/min and the UV detector wavelength was set at 245 nm. The standards were quantified by HPLC/UV from Achyranthes bidentata Blume and Achyranthes japonica Nakai, as well as Cyathula capitata Moq. and Cyathula officinalis Kuan, which are of a different genus but are comparative herbs. The method was successfully used in the analysis of Achyranthis Radix of different geographical origin or genera with relatively simple conditions and procedures, and the assay results were satisfactory for linearity, recovery, precision, accuracy, stability and robustness. The HPLC analytical method for pattern recognition analysis was validated by repeated analysis of eighteen A. bidentata Blume samples and ten A. japonica Nakai samples. The results indicate that the established HPLC/UV method is suitable for quantitation and pattern recognition analyses for quality evaluation of Achyranthis Radix.

25S-Inokosterone Description

Source:	The roots of Achyranthes bidentata Blume.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Arch Pharm Res. 2012 Aug;35(8):1449-55.

High performance liquid chromatography used for quality control of Achyranthis Radix.[Pubmed: 22941488 ]

METHODS AND RESULTS:
To establish a standard of quality control and to identify reliable Achyranthis Radix, three phytoecdysones including ecdysterone (1), 25R-inokosterone (2) and 25S-Inokosterone (3) were determined by quantitative HPLC/UV analysis. Three phytoecdysones were separated with an YMC J'sphere ODS C(18) column (250 mm × 4.6 mm, 4 μm) by isocratic elution using 0.1% formic acid in water and acetonitrile (85:15, v/v%) as the mobile phase. The flow rate was 1.0 mL/min and the UV detector wavelength was set at 245 nm. The standards were quantified by HPLC/UV from Achyranthes bidentata Blume and Achyranthes japonica Nakai, as well as Cyathula capitata Moq. and Cyathula officinalis Kuan, which are of a different genus but are comparative herbs. The method was successfully used in the analysis of Achyranthis Radix of different geographical origin or genera with relatively simple conditions and procedures, and the assay results were satisfactory for linearity, recovery, precision, accuracy, stability and robustness. The HPLC analytical method for pattern recognition analysis was validated by repeated analysis of eighteen A. bidentata Blume samples and ten A. japonica Nakai samples.
CONCLUSIONS:
The results indicate that the established HPLC/UV method is suitable for quantitation and pattern recognition analyses for quality evaluation of Achyranthis Radix.

CAS No.	19595-18-7	Price	$318 / 10mg
Catalog No.	CFN93571	Purity	>=98%
Molecular Weight	480.6	Type of Compound	Steroids
Formula	C₂₇H₄₄O₇	Physical Description	Powder
Download	COA MSDS SDF	Similar structural	Comparison (Web) (SDF)

Product Name	25S-Inokosterone
CAS No.:	19595-18-7
Catalog No.:	CFN93571
Molecular Formula:	C₂₇H₄₄O₇
Molecular Weight:	480.6 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Targets:	TNF-伪 \| IFN-纬
Source:	The roots of Achyranthes bidentata Blume.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$318 / 10mg
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cosmetic additives Compound Library Steroids Compound Library TNF-α Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0807 mL	10.4037 mL	20.8073 mL	41.6146 mL	52.0183 mL
5 mM	0.4161 mL	2.0807 mL	4.1615 mL	8.3229 mL	10.4037 mL
10 mM	0.2081 mL	1.0404 mL	2.0807 mL	4.1615 mL	5.2018 mL
50 mM	0.0416 mL	0.2081 mL	0.4161 mL	0.8323 mL	1.0404 mL
100 mM	0.0208 mL	0.104 mL	0.2081 mL	0.4161 mL	0.5202 mL

CFN98229	Ecdysterone 20,22-monoacetonide	22798-96-5	520.7	C₃₀H₄₈O₇
CFN98230	Ecdysterone 2,3:20,22-diacetonide	22798-98-7	560.8	C₃₃H₅₂O₇
CFN90027	Vitamin D3	67-97-0	384.64	C₂₇H₄₄O
CFN90049	Ergocalciferol	50-14-6	396.65	C₂₈H₄₄O
CFN90608	Dihydrocholesterol	80-97-7	388.67	C₂₇H₄₈O
CFN90040	Cholesterol	57-88-5	386.67	C₂₇H₄₆O
CFN90611	4-Beta-Hydroxycholesterol	17320-10-4	402.66	C₂₇H₄₆O₂
CFN90610	7Beta-Hydroxycholesterol	566-27-8	402.65	C₂₇H₄₆O₂
CFN91812	7-Ketocholesterol	566-28-9	400.6	C₂₇H₄₄O₂
CFN91647	7-Oxocholesteryl acetate	809-51-8	442.7	C₂₉H₄₆O₃