Luteolin-7-O-glucoside | CAS:5373-11-5

Luteolin-7-O-glucoside

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Description:

Luteolin-7-O-glucoside has cardioprotective, anti-asthmatic, anticancer, anti-inflammatory, and antioxidative activities, it can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.Luteolin-7-O-glucoside modulated the Nrf2/MAPK/ PTEN/Akt /ERK/AP-1/PI3K-Akt signaling pathways, it suppressed the expression of β-catenin.

Targets:

Wnt/β-catenin | HO-1 | Nrf2 | p38MAPK | Akt | ERK | NF-kB | AP-1 | PI3K | ROS | JNK | NOS | COX | LOX | PGE

In vitro:

Nutr Cancer. 2011;63(1):130-8.

Cancer chemopreventive potential of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn.[Pubmed: 21161823 ]

The anticarcinogenic potential of the phytocompound Luteolin-7-O-glucoside (LUT7G), isolated from the leaves of Ophiorrhiza mungos Linn, was studied against 4 different cancer cell lines (COLO 320 DM, AGS, MCF-7, and A549) and normal VERO cell line.
METHODS AND RESULTS:
The ability of LUT7G to induce apoptosis was determined by its antiradical activity, DNA fragmentation, expression of β-catenin, and chemopreventive efficacy in vivo by administering rats with DMH (20 mg/kg b.w., s.c.) for 4 consecutive wk and supplementing with 3 different doses throughout the experimental period of 16 wk. LUT7G scavenged 80% of DPPH radicals generated in vitro at 1000 μM and suppressed the expression of β-catenin to 40% at 120 μM concentrations. LUT7G induced apoptosis by scavenging ROS and suppressing the expression of β-catenin in COLO 320 DM cells and effectively inhibited ACF development in DMH-induced experimental carcinogenesis.
CONCLUSIONS:
Hence LUT7G can be a potent anticancer drug for colon carcinogenesis.

Cardiovasc Toxicol. 2016 Apr;16(2):101-10.

Protection of Luteolin-7-O-Glucoside Against Doxorubicin-Induced Injury Through PTEN/Akt and ERK Pathway in H9c2 Cells.[Pubmed: 25724325]

Luteolin-7-O-glucoside (LUTG) was isolated from the plants of Dracocephalum tanguticum Maxim. Previous research has showed that LUTG pretreatment had a significant protective effect against doxorubicin (DOX)-induced cardiotoxicity by reducing intracellular calcium overload and leakage of creatine kinase and lactate dehydrogenase. But the underlying mechanisms have not been completely elucidated.
METHODS AND RESULTS:
In the present study, we investigated the effects of LUTG on H9c2 cell morphology, viability, apoptosis, reactive oxygen species generation, and the mitochondrial transmembrane potentials. The expression of p-PTEN, p-Akt, p-ERK, p-mTOR, and p-GSK-3β were detected by Western blotting. Compared with DOX alone treatment group, the morphological injury and apoptosis of the cells in groups treated by DOX plus LUTG were alleviated, cell viability was increased, ROS generation was lowered remarkably, and mitochondrial depolarization was mitigated. In DOX group, the expression of p-PTEN was lower than normal group and the expression of p-Akt and p-ERK was higher than normal group. In the groups treated with LUTG (20 μM), the expression of p-PTEN was upregulated and the expression of p-Akt, p-ERK, p-mTOR, and p-GSK-3β was downregulated.
CONCLUSIONS:
These results indicated that the protective effects of LUTG against DOX-induced cardiotoxicity may be related to anti-apoptosis through PTEN/Akt and ERK pathway.

Luteolin-7-O-glucoside Description

Source:	The herbs of Dracocephalum ruyschiana L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2011;34(7):1032-6.

Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.[Pubmed: 21720009]

METHODS AND RESULTS:
In this study, Luteolin-7-O-glucoside (L7G), an herbal medicine isolated from Ailanthus altissima, inhibited 5-lipoxygenase (5-LOX)-dependent leukotriene C(4) (LTC(4)) production in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner with an IC(50) of 3.0 μM. To determine the action mechanism of L7G, we performed immunoblotting for cytosolic phospholipase A(2) (cPLA(2)) and mitogen-activated protein kinases (MAPKs) following c-kit ligand (KL)-induced activation of BMMCs with or without L7G. Inhibition of LTC(4) production by L7G was accompanied by a decrease in cPLA(2) phosphorylation, which occurred via the extracellular signal-regulated protein kinase-1/2 (ERK1/2) and p38 and c-Jun N-terminal kinase (JNK) pathways. In addition, L7G also attenuated mast cell degranulation in a dose-dependent manner (IC(50), 22.8 μM) through inhibition of phospholipase Cγ1 (PLCγ1) phosphorylation.
CONCLUSIONS:
Our results suggest that the anti-asthmatic activity of L7G may be mediated in part via the inhibition of LTC(4) generation and mast cell degranulation.

Cell Research:

Food Chem Toxicol. 2014 Mar;65:70-5.

Luteolin and luteolin-7-O-glucoside strengthen antioxidative potential through the modulation of Nrf2/MAPK mediated HO-1 signaling cascade in RAW 264.7 cells.[Pubmed: 24361407]

It has been understood that glycosidic forms of flavonoids were hydrolyzed by gut bacteria and absorbed as aglycones. However, several reports suggested that glycosides were partly absorbed without hydrolysis and remained biologically active.
METHODS AND RESULTS:
In this study, we evaluated the antioxidative potential of luteolin and Luteolin-7-O-glucoside, glycosidic form of luteolin, against the oxidative damage and compared their antioxidative mechanisms in RAW 264.7 cells. Heme oxygenase-1 (HO-1), one of the phase II enzymes showing an antioxidative activity, was potently induced by luteolin and Luteolin-7-O-glucoside treatment, which was in accordance with the translocated nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) into nucleus. Moreover, luteolin and the Luteolin-7-O-glucoside activated HO-1 expression by p38 and c-Jun NH2-terminal kinase (JNK) regulation. In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the Luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.
CONCLUSIONS:
Consequently, luteolin and Luteolin-7-O-glucoside potently strengthen the HO-1-mediated antioxidative potential through the modulation of the Nrf2/MAPK signaling pathways.

Nutr Res Pract. 2013 Dec;7(6):423-9.

Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells.[Pubmed: 24353826]

Luteolin is a flavonoid found in abundance in celery, green pepper, and dandelions. Previous studies have shown that luteolin is an anti-inflammatory and anti-oxidative agent.
METHODS AND RESULTS:
In this study, the anti-inflammatory capacity of luteolin and one of its glycosidic forms, Luteolin-7-O-glucoside, were compared and their molecular mechanisms of action were analyzed. In lipopolysaccharide (LPS)-activated RAW 264.7 cells, luteolin more potently inhibited the production of nitric oxide (NO) and prostaglandin E2 as well as the expression of their corresponding enzymes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) than Luteolin-7-O-glucoside. The molecular mechanisms underlying these effects were investigated to determine whether the inflammatory response was related to the transcription factors, nuclear factor (NF)-κB and activator protein (AP)-1, or their upstream signaling molecules, mitogen-activated protein kinases (MAPKs) and phosphoinositide 3-kinase (PI3K). Luteolin attenuated the activation of both transcription factors, NF-κB and AP-1, while Luteolin-7-O-glucoside only impeded NF-κB activation. However, both flavonoids inhibited Akt phosphorylation in a dose-dependent manner.
CONCLUSIONS:
Consequently, luteolin more potently ameliorated LPS-induced inflammation than Luteolin-7-O-glucoside, which might be attributed to the differentially activated NF-κB/AP-1/PI3K-Akt pathway in RAW 264.7 cells.

CAS No.	5373-11-5	Price	$60 / 20mg
Catalog No.	CFN98565	Purity	>=98%
Molecular Weight	448.38	Type of Compound	Flavonoids
Formula	C₂₁H₂₀O₁₁	Physical Description	Yellow powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	Luteolin-7-O-glucoside
CAS No.:	5373-11-5
Catalog No.:	CFN98565
Molecular Formula:	C₂₁H₂₀O₁₁
Molecular Weight:	448.38 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Targets:	Wnt/尾-catenin \| HO-1 \| Nrf2 \| p38MAPK \| Akt \| ERK \| NF-kB \| AP-1 \| PI3K \| ROS \| JNK \| NOS \| COX \| LOX \| PGE
Source:	The herbs of Dracocephalum ruyschiana L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$60 / 20mg
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL	44.605 mL	55.7563 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL	8.921 mL	11.1513 mL
10 mM	0.223 mL	1.1151 mL	2.2303 mL	4.4605 mL	5.5756 mL
50 mM	0.0446 mL	0.223 mL	0.4461 mL	0.8921 mL	1.1151 mL
100 mM	0.0223 mL	0.1115 mL	0.223 mL	0.4461 mL	0.5576 mL

CFN98100	Lethedoside A	221289-20-9	490.5	C₂₄H₂₆O₁₁
CFN98201	Lethedioside A	221289-31-2	622.6	C₂₉H₃₄O₁₅
CFN97595	5-Hydroxy-7,8,2',5'-tetramethoxyflavone 5-O-glucoside	942626-75-7	520.49	C₂₅H₂₈O₁₂
CFN98565	Luteolin-7-O-glucoside	5373-11-5	448.38	C₂₁H₂₀O₁₁
CFN98512	Luteolin-7-O-glucuronide	29741-10-4	462.36	C₂₁H₁₈O₁₂
CFN95055	Lonicerin	25694-72-8	594.5	C₂₇H₃₀O₁₅
CFN93556	Luteolin 7-rutinoside	20633-84-5	594.52	C₂₇H₃₀O₁₅
CFN98568	Luteollin 5-glucoside	20344-46-1	448.38	C₂₁H₂₀O₁₁
CFN95127	Yuanhuanin	83133-14-6	462.4	C₂₂H₂₂O₁₁
CFN95128	Yuankanin	77099-20-8	578.5	C₂₇H₃₀O₁₄