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    Natural Products
    3',4',7,8-Tetrahydroxyflavone
    3',4',7,8-Tetrahydroxyflavone
    Information
    CAS No. 3440-24-2 Price
    Catalog No.CFN70342Purity>=98%
    Molecular Weight286.2Type of CompoundFlavonoids
    FormulaC15H10O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    3',4',7,8-Tetrahydroxyflavone

    3',4',7,8-Tetrahydroxyflavone
    Product Name 3',4',7,8-Tetrahydroxyflavone
    CAS No.: 3440-24-2
    Catalog No.: CFN70342
    Molecular Formula: C15H10O6
    Molecular Weight: 286.2 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: Antifection | RANKL | c-Fos | NFATc1
    Source: The herbs of Rhus succedanea L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Appl. Sci.2020, 10(23), 8729
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Flavonoids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: 3',4',7,8-Tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases. 3',4',7,8-Tetrahydroxyflavone exhibits antibacterial activity against S. mutans. It can absorb UV light and form photooxidation derivatives.
    Targets: Antifection | RANKL | c-Fos | NFATc1
    In vitro:
    Die Pharmazie, 01 Mar 2017, 72(3):161-166.
    3',4',7,8-Tetrahydroxyflavone inhibits RANKL-induced osteoclast formation and bone resorption.[Reference: WebLink]
    Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-Tetrahydroxyflavone is a flavonoid from Acacia confusa.
    METHODS AND RESULTS:
    In the present study, we found that 3',4',7,8-Tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7,8-Tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K. In addition, 3',4',7,8-Tetrahydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3',4',7,8-Tetrahydroxyflavone inhibited RANKL-induced expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, ectopic overexpression of a constitutively active form of NFATc1 completely rescued the anti-osteoclastogenic effect of 3',4',7,8-Tetrahydroxyflavone, suggesting that the anti-osteoclastogenic effect was mainly attributed to the reduction in NFATc1 expression.
    CONCLUSIONS:
    Taken together, our data suggest that 3',4',7,8-Tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases.
    Archives of Pharmacal Research, 2013, 36(6):723-730.
    Antibacterial substances fromAlbizia myriophyllawood against cariogenicStreptococcus mutans.[Reference: WebLink]
    Albizia myriophylla has been used for long by Thai traditional healers as an important ingredient herb in Thai herbal formulas for caries.
    METHODS AND RESULTS:
    In this study, three flavonoids lupinifolin (6), 8-methoxy-7,3',4'-trihydroxyflavone (7), and 7,8,3',4'-tetrahydroxyflavone (3',4',7,8-Tetrahydroxyflavone,8), a triterpenoid lupeol (3) as well as four sterols β-sitosterone (1), stigmasta-5,22-dien-3-one (2), β-sitosterol (4), and stigmasterol (5) were isolated from A. myriophylla wood. The antibacterial activity of these compounds against Streptococcus mutans ATCC 25175 was performed using broth microdilution method. All compounds exhibited antibacterial activity against S. mutans with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) ranging from 1-256 and 2-256 μg/ml, respectively. Among the isolated compounds, lupinifolin (6) was found to be the most potent with MIC and MBC of 1 and 2 μg/ml, respectively. Lupinifolin (6) also showed a strong activity against ten clinical isolates of S. mutans with MIC and MBC ranging from 0.25-2 and 0.5-8 μg/ml, respectively.
    CONCLUSIONS:
    These results reported the bioactive ingredients of A. myriophylla which support its ethnomedical claims as well. Lupinifolin (6) may have a potential to be a natural anticariogenic agent.
    3',4',7,8-Tetrahydroxyflavone Description
    Source: The herbs of Rhus succedanea L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4941 mL 17.4703 mL 34.9406 mL 69.8812 mL 87.3515 mL
    5 mM 0.6988 mL 3.4941 mL 6.9881 mL 13.9762 mL 17.4703 mL
    10 mM 0.3494 mL 1.747 mL 3.4941 mL 6.9881 mL 8.7352 mL
    50 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.3976 mL 1.747 mL
    100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.6988 mL 0.8735 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Polymer Degradation and Stability, 2014, 105(JUL.):42-47.
    Study on inhibition mechanisms of light-induced wood radicals by Acacia confusa heartwood extracts.[Reference: WebLink]
    The aim of this study was to investigate the inhibition mechanisms of light-induced wood radicals by Acacia confusa heartwood extracts (AcE).
    METHODS AND RESULTS:
    Wood radical scavenging analysis was determined by ESR spectroscopy. The results obtained demonstrated that wood radicals could be inhibited through UV absorption of AcE. According to results of AcE photooxidation derivative analyses detected by HPLC–DAD, HPLC–MS/MS and FTIR spectroscopy, o-quinones, peroxides and other oxidation derivatives were yielded from flavonols (such as melanoxetin and transilitin) in AcE; okanin (chalcone) might be formed from 7,8,3′,4′-tetrahydroxyflavanone (3',4',7,8-Tetrahydroxyflavone ,flavanone); 7,8,3′,4′-tetrahydroxyflavone and 7,3′,4′-trihydroxyflavone (flavones) would transform to flavanone. On the basis of GPC analysis results, proanthocyanidins and derivatives of higher molecular weight might be polymerized from melacacidin (flavan-3,4-diol).
    CONCLUSIONS:
    Taken together, these results clearly demonstrated that A. confusa heartwood extract can absorb UV light and form photooxidation derivatives. Accordingly, wood radicals induced by UV light were inhibited and consequently wood photodegradation was retarded.
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