Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    3-Deoxysappanone B
    Information
    CAS No. 113122-54-6 Price
    Catalog No.CFN99229Purity>=98%
    Molecular Weight286.3 Type of CompoundFlavonoids
    FormulaC16H14O5Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universite de Lille1 (France)
  • University of Helsinki (Finland)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Kyoto University (Japan)
  • Hamdard University (India)
  • University of Liège (Belgium)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Cancer Research Initatives Foun... (Malaysia)
  • University of South Australia (Australia)
  • Kyushu University (Japan)
  • University of Vienna (Austria)
  • More...
  • Package
    Featured Products
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    Decursin

    Catalog No: CFN98509
    CAS No: 5928-25-6
    Price: $228/20mg
    Ginsenoside Rg6

    Catalog No: CFN90565
    CAS No: 147419-93-0
    Price: $318/5mg
    Kushenol C

    Catalog No: CFN92391
    CAS No: 99119-73-0
    Price: $468/10mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $268/5mg
    N-trans-Feruloyltyramine

    Catalog No: CFN97135
    CAS No: 66648-43-9
    Price: $288/10mg

    3-Deoxysappanone B

    3-Deoxysappanone B
    Product Name 3-Deoxysappanone B
    CAS No.: 113122-54-6
    Catalog No.: CFN99229
    Molecular Formula: C16H14O5
    Molecular Weight: 286.3 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: NO
    Source: The heartwoods of Caesalpinia sappan
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Appl. Sci.2020, 10,1304
  • Ann Transl Med.2019, 7(23):731
  • J Neuroinflammation.2020, 17(1):75.
  • PLoS One.2018, 13(11):e0208055
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Genes Genomics.2020, 10.1007
  • Br J Pharmacol.2018, 175(6):902-923
  • Cell Biochem Funct.2018, 36(6):303-311
  • Pharmacol Rep.2019, 71(2):289-298
  • Drug Des Devel Ther.2020, 14:61-71
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Vasorelaxation Compound Library
  • Estrogenic effect Compound Library
  • Anti-estrogenic effect Compound Library
  • Flavonoids Compound Library
  • NO Inhibitor Library
  • Biological Activity
    Description: 3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.
    Targets: NO
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):731-4.
    Vasorelaxation effects of homoisoflavonoids from Caesalpinia sappan in rat thoracic aortic rings.[Pubmed: 19624017]
    To identify and elucidate the vasorelaxant activity of homoisoflavonoids, the main chemical components from Lignum Sappan (the stems of Caesalpinia sappan), in isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 micromol x L(-1)) and KCl (60 mmol x L(-1)).
    METHODS AND RESULTS:
    The tension of rat thoracic aorta rings was used to evaluated the vasorelaxant activities of four homoisoflavonoids, brazlin (1), (E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (2), sappanone B (3), 3-Deoxysappanone B (4). Cumulative addition of homoisoflavonoids (2, 3 and 4) (50-1000 micromol x L(-1)) exhibited an acute relaxation either in endothelium-intact or endothelium-denuded rings in a concentration-dependent manner. However, this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of endothelial nitric oxide synthase (eNOS) inhibitor, N(W)-nitro-L-arginine methyl ester (L-NNA, 100 micromol x L(-1)), and a soluble guanylate cylcase (sGC) inhibitor, methylene blue (MB, 10 micromol x L(-1)) when addition of variation homoisoflavonoids brazlin (1) (50-1000 micromol x L(-1)).
    CONCLUSIONS:
    These results indicate that normo-homoisoflavonoids (2, 3 and 4) from Caesalpinia sappan mediates endothelium-independent vasodilator action in rat thoracic aortic rings, while the variation homoisoflavonoids brazlin elicits endothelium-dependent relaxation might via nitric oxide (NO)-cGMP pathway. This research could explain the pharmacological activities of homoisoflavonoids to a certain degree.
    3-Deoxysappanone B Description
    Source: The heartwoods of Caesalpinia sappan
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Cannabisin A

    Catalog No: CFN95287
    CAS No: 130508-46-2
    Price: $318/5mg
    vibo-Quercitol

    Catalog No: CFN98778
    CAS No: 488-76-6
    Price: $218/20mg
    Diosniposide B

    Catalog No: CFN95333
    CAS No: N/A
    Price: $413/5mg
    4,5-Dimethoxycanthin-6-one

    Catalog No: CFN99847
    CAS No: 18110-87-7
    Price: $333/5mg
    Randaiol

    Catalog No: CFN96098
    CAS No: 87562-14-9
    Price: $333/5mg
    Betmidin

    Catalog No: CFN95047
    CAS No: 35589-22-1
    Price: $413/5mg
    Vanillic acid glucoside

    Catalog No: CFN95257
    CAS No: 32142-31-7
    Price: $368/5mg
    Ganoderic acid C6

    Catalog No: CFN92290
    CAS No: 105742-76-5
    Price: $368/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Molecules. 2008 Aug 28;13(8):1923-30.
    A new 3-benzylchroman derivative from Sappan Lignum (Caesalpinia sappan).[Pubmed: 18794793]

    METHODS AND RESULTS:
    3'-Deoxy-4-O-methylepisappanol, a new 3-benzylchroman derivative, was isolated from Sappan Lignum, together with thirteen known chemical compounds identified as protosappanin A, sappanchalcone, sappanone B, palmitic acid, (+)-(8S,8'S)-bisdihydrosiringenin, brazilein, 3-deoxysappanchalcone, (+)-lyoniresinol, 3-Deoxysappanone B, protosappanin B, isoprotosappanin B, 3'-O-methylbrazilin and brazilin, respectively.
    CONCLUSIONS:
    Among these known compounds, this is the first time that (+)-(8S,8'S)-bisdihydrosiringenin was obtained from the family Caesalpiniaceae.
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    Decursin

    Catalog No: CFN98509
    CAS No: 5928-25-6
    Price: $228/20mg
    Ginsenoside Rg6

    Catalog No: CFN90565
    CAS No: 147419-93-0
    Price: $318/5mg
    Kushenol C

    Catalog No: CFN92391
    CAS No: 99119-73-0
    Price: $468/10mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $268/5mg
    N-trans-Feruloyltyramine

    Catalog No: CFN97135
    CAS No: 66648-43-9
    Price: $288/10mg