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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Int J Mol Sci.2019, 21(1):E265Plants (Basel).2021, 10(11):2525.Saudi Pharm J.2019, 27(1):145-153The Pharmaceutical Society of Jap...2018...Phytomedicine.2019, 56:48-56Front Pharmacol.2021, 12:744624.Food Bioscience2022, 50:102187.Molecules.2019, 24(4):E744
Ulm University Medical Center...2020...Biochem Biophys Res Commun....2020...Molecules.2022, 27(2):451.J Agric Food Chem.2015, 63(44):9869-78Med Sci Monit.2019, 25:9499-9508Food and Bioprocess Technology...2017...Phytomedicine.2021, 84:153501. Appl. Sci.2021, 11(19),9343.
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3-Deoxysappanone B
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manager@chemfaces.com
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service@chemfaces.com
Tel:
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+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Heliyon.2023, e12684.Sci Rep.2019, 9:12132Environ Toxicol.2019, 34(4):513-520.Appl. Sci.2022, 12(4), 2032.Lab Chip.2018, 18(6):971-978Neurotox Res.2020, 38(1):163-174.Nutrients.2017, 10(1)J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.Evid Based Complement Alternat Med.2022, 2022:3483511Food Chem.2017, 221:1135-1144
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium-
independent vasodilator action in rat thoracic aortic rings. |
| Targets: |
NO |
| In vitro: |
| Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):731-4. | | Vasorelaxation effects of homoisoflavonoids from Caesalpinia sappan in rat thoracic aortic rings.[Pubmed: 19624017] | To identify and elucidate the vasorelaxant activity of homoisoflavonoids, the main chemical components from Lignum Sappan (the stems of Caesalpinia sappan), in isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 micromol x L(-1)) and KCl (60 mmol x L(-1)).
METHODS AND RESULTS:
The tension of rat thoracic aorta rings was used to evaluated the vasorelaxant activities of four homoisoflavonoids, brazlin (1), (E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (2), sappanone B (3), 3-Deoxysappanone B (4).
Cumulative addition of homoisoflavonoids (2, 3 and 4) (50-1000 micromol x L(-1)) exhibited an acute relaxation either in endothelium-intact or endothelium-denuded rings in a concentration-dependent manner. However, this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of endothelial nitric oxide synthase (eNOS) inhibitor, N(W)-nitro-L-arginine methyl ester (L-NNA, 100 micromol x L(-1)), and a soluble guanylate cylcase (sGC) inhibitor, methylene blue (MB, 10 micromol x L(-1)) when addition of variation homoisoflavonoids brazlin (1) (50-1000 micromol x L(-1)).
CONCLUSIONS:
These results indicate that normo-homoisoflavonoids (2, 3 and 4) from Caesalpinia sappan mediates endothelium-independent vasodilator action in rat thoracic aortic rings, while the variation homoisoflavonoids brazlin elicits endothelium-dependent relaxation might via nitric oxide (NO)-cGMP pathway. This research could explain the pharmacological activities of homoisoflavonoids to a certain degree. |
|
3-Deoxysappanone B Description
| Source: |
The heartwoods of Caesalpinia sappan |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.4928 mL |
17.4642 mL |
34.9284 mL |
69.8568 mL |
87.321 mL |
| 5 mM |
0.6986 mL |
3.4928 mL |
6.9857 mL |
13.9714 mL |
17.4642 mL |
| 10 mM |
0.3493 mL |
1.7464 mL |
3.4928 mL |
6.9857 mL |
8.7321 mL |
| 50 mM |
0.0699 mL |
0.3493 mL |
0.6986 mL |
1.3971 mL |
1.7464 mL |
| 100 mM |
0.0349 mL |
0.1746 mL |
0.3493 mL |
0.6986 mL |
0.8732 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Molecules. 2008 Aug 28;13(8):1923-30. | | A new 3-benzylchroman derivative from Sappan Lignum (Caesalpinia sappan).[Pubmed: 18794793] |
METHODS AND RESULTS:
3'-Deoxy-4-O-methylepisappanol, a new 3-benzylchroman derivative, was isolated from Sappan Lignum, together with thirteen known chemical compounds identified as protosappanin A, sappanchalcone, sappanone B, palmitic acid, (+)-(8S,8'S)-bisdihydrosiringenin, brazilein, 3-deoxysappanchalcone, (+)-lyoniresinol, 3-Deoxysappanone B, protosappanin B, isoprotosappanin B, 3'-O-methylbrazilin and brazilin, respectively.
CONCLUSIONS:
Among these known compounds, this is the first time that (+)-(8S,8'S)-bisdihydrosiringenin was obtained from the family Caesalpiniaceae. |
|
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